Podcast
Questions and Answers
What is the most common form of amyloidosis?
What is the most common form of amyloidosis?
- Reactive systemic AA amyloid (due to a systemic inflammatory disease)
- Aβ amyloid (Alzheimer’s disease)
- Î’2-macroglobulin amyloid (associated with hemodialysis)
- Primary AL amyloid (due to a plasma cell disorder) (correct)
Which type of amyloid is associated with hereditary disease?
Which type of amyloid is associated with hereditary disease?
- Alpha-ANF in atria of the heart
- ATTR amyloid in peripheral and autonomic nerves (correct)
- AA amyloid in rheumatoid arthritis
- A-Cal amyloid in medullary thyroid cancer
Which of the following amyloid types is linked to a systemic inflammatory response?
Which of the following amyloid types is linked to a systemic inflammatory response?
- Primary AL amyloid
- Aβ amyloid
- Î’2-macroglobulin amyloid
- Reactive systemic AA amyloid (correct)
Which type of amyloid is commonly associated with patients undergoing hemodialysis?
Which type of amyloid is commonly associated with patients undergoing hemodialysis?
Which amyloid type is not typically related to cancer?
Which amyloid type is not typically related to cancer?
Which of the following symptoms is NOT commonly associated with general manifestations of amyloid?
Which of the following symptoms is NOT commonly associated with general manifestations of amyloid?
What is a major consequence of amyloid infiltration into the kidney?
What is a major consequence of amyloid infiltration into the kidney?
Which of the following complications can arise from cardiac amyloidosis?
Which of the following complications can arise from cardiac amyloidosis?
In amyloidosis, microhemorrhages are mainly caused by what pathological change?
In amyloidosis, microhemorrhages are mainly caused by what pathological change?
What type of treatment is commonly utilized for AL amyloidosis?
What type of treatment is commonly utilized for AL amyloidosis?
The presence of massive macroglossia in an amyloidosis patient indicates what?
The presence of massive macroglossia in an amyloidosis patient indicates what?
What is the main purpose of the Congo Red stain in diagnosing amyloidosis?
What is the main purpose of the Congo Red stain in diagnosing amyloidosis?
What does the prognosis generally indicate for patients diagnosed with amyloidosis?
What does the prognosis generally indicate for patients diagnosed with amyloidosis?
Which treatment is utilized for the AA type of amyloidosis?
Which treatment is utilized for the AA type of amyloidosis?
What is a common characteristic of amyloidosis in relation to its etiology?
What is a common characteristic of amyloidosis in relation to its etiology?
What is the primary characteristic that amyloid proteins exhibit?
What is the primary characteristic that amyloid proteins exhibit?
Which property is indicative of amyloid when using Congo Red staining?
Which property is indicative of amyloid when using Congo Red staining?
Which of the following forms of amyloid is associated with plasma cell disorders?
Which of the following forms of amyloid is associated with plasma cell disorders?
What role does electron microscopy play in the diagnosis of amyloidosis?
What role does electron microscopy play in the diagnosis of amyloidosis?
What is the sensitivity of an abdominal fat pad aspirate in diagnosing amyloidosis compared to a biopsy from affected organs?
What is the sensitivity of an abdominal fat pad aspirate in diagnosing amyloidosis compared to a biopsy from affected organs?
Why can't a diagnosis of amyloidosis be made without tissue?
Why can't a diagnosis of amyloidosis be made without tissue?
How do amyloid fibrils typically appear under electron microscopy?
How do amyloid fibrils typically appear under electron microscopy?
What is the composition percentage of amyloid fibril proteins in amyloid?
What is the composition percentage of amyloid fibril proteins in amyloid?
Which type of amyloid is specifically associated with Alzheimer’s disease?
Which type of amyloid is specifically associated with Alzheimer’s disease?
Which histological stain is essential for diagnosing amyloid deposits in tissue?
Which histological stain is essential for diagnosing amyloid deposits in tissue?
What characteristic appearance is seen with amyloid when viewed histologically?
What characteristic appearance is seen with amyloid when viewed histologically?
What is a less invasive method used to detect amyloid presence before deeper biopsies?
What is a less invasive method used to detect amyloid presence before deeper biopsies?
What kind of appearance do amyloid fibrils have in organ tissues when diagnosed with routine stains?
What kind of appearance do amyloid fibrils have in organ tissues when diagnosed with routine stains?
Which type of test is used for precise identification of specific types of amyloid?
Which type of test is used for precise identification of specific types of amyloid?
What is the key histologic stain used to confirm a diagnosis of amyloid in tissue?
What is the key histologic stain used to confirm a diagnosis of amyloid in tissue?
Which type of amyloidosis is primarily associated with a plasma cell disorder?
Which type of amyloidosis is primarily associated with a plasma cell disorder?
What is primarily used to type different kinds of amyloid proteins?
What is primarily used to type different kinds of amyloid proteins?
What is the amyloid fibril protein associated with Reactive Systemic Amyloidosis?
What is the amyloid fibril protein associated with Reactive Systemic Amyloidosis?
What condition is characterized by amyloid deposits in the atria of the heart?
What condition is characterized by amyloid deposits in the atria of the heart?
Which amyloid fibril protein is primarily associated with Alzheimer's Disease?
Which amyloid fibril protein is primarily associated with Alzheimer's Disease?
Which type of amyloidosis is characterized by amyloid deposits in the pancreatic islets?
Which type of amyloidosis is characterized by amyloid deposits in the pancreatic islets?
What etiology is commonly associated with Hemodialysis-Associated Amyloidosis?
What etiology is commonly associated with Hemodialysis-Associated Amyloidosis?
What is the amyloid fibril protein involved in Hereditary Amyloid due to Familial Mediterranean Fever?
What is the amyloid fibril protein involved in Hereditary Amyloid due to Familial Mediterranean Fever?
Which type of amyloidosis is commonly seen in chronic inflammatory conditions?
Which type of amyloidosis is commonly seen in chronic inflammatory conditions?
What is the amyloid fibril protein in Systemic Senile Amyloidosis?
What is the amyloid fibril protein in Systemic Senile Amyloidosis?
Which amyloidosis involves deposits in multiple organs, primarily affecting the heart?
Which amyloidosis involves deposits in multiple organs, primarily affecting the heart?
In which condition is monoclonal light chains found in urine, associated with 'Bence-Jones proteinuria'?
In which condition is monoclonal light chains found in urine, associated with 'Bence-Jones proteinuria'?
What is a common characteristic of localized amyloidosis?
What is a common characteristic of localized amyloidosis?
Flashcards are hidden until you start studying
Study Notes
Amyloidosis Overview
- Amyloidosis is characterized by extracellular deposits of fibrillary proteins causing tissue damage and functional issues.
- Over 20 different proteins can form amyloid, all resulting in specific protein formations with classic tissue appearances.
Physical and Chemical Properties
- Amyloid proteins are insoluble; they aggregate into non-branching fibrils measuring 7.5-10 nm in diameter.
- Exhibit a characteristic β-pleated sheet configuration present in all amyloid types.
Diagnosis of Amyloidosis
- Diagnosis requires tissue samples; non-invasive methods include abdominal fat pad aspirate.
- Congo Red stain is the key histological test, showing a red/salmon color, with apple green birefringence under polarized light.
Composition of Amyloid
- Composed of 95% fibril proteins, including:
- AL (light chains from plasma cell disorders).
- AA (associated with systemic inflammatory diseases like rheumatoid arthritis).
- Aβ (β-amyloid linked to Alzheimer's disease).
- Contains 5% amyloid P component and other glycoproteins.
More Advanced Diagnostic Techniques
- Utilization of electron microscopy can identify amyloid fibrils at an ultrastructural level.
- Mass spectrometry can precisely classify amyloid type by analyzing micro-dissected tissue.
Specific Types of Amyloid
- Primary Amyloidosis (AL Type): Linked to plasma cell disorders producing monoclonal light chains, causing "Bence-Jones proteinuria."
- Reactive Systemic Amyloidosis (AA Type): Associated with chronic inflammatory conditions, derived from serum amyloid A protein.
- Hemodialysis-Associated Amyloidosis: Results from long-term dialysis leading to β-2 microglobulin accumulation.
- LECT2 Amyloid: A recently recognized type; comprised of LECT2 protein, often affecting Hispanic populations.
- Familial Mediterranean Fever: An autosomal recessive disorder resulting from excess IL-1 production related to pyrin gene mutations.
Clinical Manifestations
- General symptoms include weakness, weight loss, and syncope.
- Skin: Tan/pink papules and periorbital hemorrhage.
- Kidney: Proteinuria and risk of renal failure due to amyloid infiltration.
- Heart: Congestive heart failure and arrhythmias due to myocardial stiffness from amyloid deposits.
- Gastrointestinal Tract: Malabsorption and enlargement of the tongue (macroglossia).
- Vascular Involvement: Fragile blood vessels can cause severe hemorrhage.
Treatment Options
- Treatment is type and etiology-dependent:
- For AL type, chemotherapy and bone marrow transplants are common.
- For AA type, managing the underlying inflammatory condition is critical.
- Alzheimer's treatment includes investigational drugs targeting β-amyloid.
- Developments in therapy like Eprodisate aim to inhibit amyloid deposition but have shown disappointing trial results.
Summary Points
- Amyloidosis encompasses various systemic or localized forms and may include hereditary factors.
- Tissue biopsy is necessary for diagnosis, with Congo Red staining being essential.
- Prognosis can be poor, but ongoing research is developing new therapeutic options.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
