Aminopenicillins

Podcast

Play an AI-generated podcast conversation about this lesson

Download our mobile app to listen on the go

Get App

Questions and Answers

What are the other drugs included in Aminopenicillins?

Ampicillin, hetacillin and amoxicillin

Aminopenicillins are ranked highly important antimicrobials

True (A)

Which of the following statements about aminopenicillins is true?

They are hydrolyzed by beta-lactamases (correct)
They are inactivated by gastric acid
They cannot penetrate the outer layer of Gram-negative bacteria
They have a long half-life in the body

Hetacillin is a pro-drug of which aminopenicillin?

Ampicillin (B) Signup and view all the answers

Which of the following aminopenicillins has greater oral bioavailability (%F) in dogs?

Amoxicillin (B) Signup and view all the answers

Sodium ampicillin is poorly soluble vs ampicillin trihydrate which is water soluble

False (B) Signup and view all the answers

Why do aminopenicillins not produce therapeutic concentrations when administered orally to horses and ruminants?

They are poorly absorbed in the gastrointestinal tract (B) Signup and view all the answers

What is the volume of distribution of Aminopenicillins ?

Low-moderate (A) Signup and view all the answers

Aminopenicillins have moderate protein binding

True (A) Signup and view all the answers

How are aminopenicillins primarily eliminated from the body?

Urinary excretion (unchanged) (D) Signup and view all the answers

Aminopenicillins have a ___________________ (short/long) half life

Short Signup and view all the answers

Which of the following drugs exhibits a synergistic effect when combined with aminopenicillins?

Clavulanic acid (B), Sulbactam (D) Signup and view all the answers

Why are aminopenicillins not recommended for concurrent administration with bacteriostatic drugs?

Bacteriostatic drugs inhibit bacterial growth, reducing the efficacy of aminopenicillins (B) Signup and view all the answers

When ____________ are mixed with Aminopenicillins, they produce precipitates. This is not recommended.

Aminoglycosides Signup and view all the answers

Aminopenicillins spectrum of activity is a _____________ spectrum

Broad Signup and view all the answers

Which of the following statements about the spectrum of aminopenicillins is true?

Amoxicillin has better activity against Gram-negative bacteria than ampicillin (B) Signup and view all the answers

What is the primary purpose of combining aminopenicillins with β-lactamase inhibitors like clavulanic acid and sulbactam?

To extend the spectrum of activity to β-lactamase-producing bacteria (B) Signup and view all the answers

Which formulation of amoxicillin-clavulanic acid is available for veterinary use?

Oral (tablets or suspension) (C) Signup and view all the answers

Which of the following infections in small animals is commonly treated with aminopenicillins?

Superficial bacterial folliculitis (A), Bacterial respiratory diseases (B), UTI (D) Signup and view all the answers

Hetacillin is available as an intramammary infusion for which species?

Cattle (B) Signup and view all the answers

Amoxicillin-clavulanic acid is only available as oral formulations for humans and small animals

True (A) Signup and view all the answers

Flashcards

Aminopenicillins

Ampicillin, hetacillin, and amoxicillin.

Aminopenicillins Importance

True. They are important for treating various infections.