Recent Lessons

Show all results for ""

Feature Overview

Ace your exams with our all-in-one platform for creating and sharing quizzes and tests.

Quizzes

Create quizzes and tests automatically from your content using AI.

Flashcards

Automatically turn your notes into digital flashcards.

Share, Export & Embed

Share with classmates or export to Excel and your learning management system.

Stats & Reporting

Auto-grading quizzes and tests with detailed stats and reports.

Mobile Apps

The smarter way to study – wherever you are.

Pricing

Search...

10 Questions

0 Views

Aminoglycosides: Mechanism and Use

Choose a study mode

Play Quiz

Study Flashcards

Spaced Repetition

Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the primary mechanism of action of aminoglycosides?

Bacteriostatic, time dependent

Bactericidal, concentration dependent (correct)

Bacteriostatic, concentration dependent

Bactericidal, time dependent

What factors influence the efficacy of aminoglycosides?

The maximum concentration (Cmax) of the drug above the MIC (correct)

The duration of drug administration

The renal clearance rate of the drug

The minimum inhibitory concentration (MIC) of the bacteria

To what extent should the Cmax of aminoglycosides exceed the MIC for optimal efficacy?

2-3 times higher than MIC

4-6 times higher than MIC

Above 12 times higher than MIC

8-10 times higher than MIC (correct)

Which statement accurately describes the relationship between the Cmax and MIC for aminoglycosides?

Cmax should be significantly greater than the MIC Signup and view all the answers

What type of drug activity is associated with aminoglycosides?

Bactericidal action against aerobic gram-negative bacteria Signup and view all the answers

How does increasing the dosage of an antibiotic influence the post-antibiotic effect (PAE)?

It prolongs the duration of PAE. Signup and view all the answers

What is a significant benefit of using extended interval dosing of antibiotics?

Convenience and reduced nephrotoxicity. Signup and view all the answers

Which of the following statements is true regarding extended interval dosing?

It involves administering a single large dose once daily. Signup and view all the answers

What effect does a single large dose have in the context of antibiotics?

It could enhance convenience and reduce toxicity. Signup and view all the answers

Which factor primarily contributes to extending the post-antibiotic effect (PAE)?

Size of the administered dose. Signup and view all the answers

Study Notes

Aminoglycosides: Mechanism of Action

Bactericidal action: Efficacy depends on peak drug concentration (Cmax) exceeding the minimum inhibitory concentration (MIC) by 8-10 times.
Post-antibiotic effect (PAE): Duration increases with higher doses.
Extended-interval dosing: Single large daily dose reduces nephrotoxicity and improves patient compliance.
Vertigo: A potential side effect, particularly with streptomycin.
Neuromuscular paralysis: Risk increases with high-dose, rapid infusions or concurrent use of neuromuscular blockers.

Aminoglycoside Use and Limitations

Not recommended as monotherapy for staphylococcal infections (rapid resistance development, poor lung penetration).
Generally ineffective against Pseudomonas and streptococci.
Primarily used topically or orally due to toxicity limitations (e.g., neomycin unsuitable for injection).
Topical application: Neomycin-polymyxin-bacitracin combinations treat infected skin lesions.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Description

This quiz covers the mechanism of action, use, and limitations of aminoglycosides. Explore their bactericidal effects, dosing strategies, and potential side effects. Understand when these antibiotics should not be used alone and their applications in treatment.