Amino Acids and Protein Structure Quiz
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Questions and Answers

What type of mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer leading to polymerization?

  • Glu6 to Val6 mutation (correct)
  • Val6 to Leu88 mutation
  • Leu88 to Phe85 mutation
  • Glu6 to Phe85 mutation

    • Who are the scientists credited for pioneering work in understanding the basic structural features of proteins?

  • John Baenziger and Linus Pauling
  • Linus Pauling and John Baenziger
  • Linus Pauling and Robert Corey (correct)
  • Robert Corey and John Baenziger

    • What dictates the function of proteins according to the text?

  • The presence of hydrogen bonds
  • The type of RNA involved
  • The 3D arrangement of amino acids (correct)
  • The length of the polypeptide chain

    • What drives the 3D structure of proteins according to the text?

    <p>Chemistry</p> Signup and view all the answers

    In the active site of the enzyme trypsin, which group is positioned to attack the carbonyl group of a substrate?

    <p>Nucleophilic OH of Ser195</p> Signup and view all the answers

    What is the role of Linus Pauling and Robert Corey in our understanding of protein structure?

    <p>They are credited for pioneering work in understanding the basic structural features of proteins.</p> Signup and view all the answers

    What is the significance of the βE6V mutation in HbS?

    <p>It creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer leading to polymerization.</p> Signup and view all the answers

    What drives the 3D structure of proteins according to the text?

    <p>Chemistry drives 3D structure dictating function.</p> Signup and view all the answers

    What is the function of the nucleophilic OH of Ser195 in the active site of trypsin?

    <p>It is positioned to attack the carbonyl group of a substrate.</p> Signup and view all the answers

    What dictates the function of proteins according to the text?

    <p>The 3D arrangement of amino acids dictates function.</p> Signup and view all the answers

    Study Notes

    Protein Structure and Function

    • A point mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer, leading to polymerization.

    Pioneers in Protein Structure

    • Linus Pauling and Robert Corey are credited for pioneering work in understanding the basic structural features of proteins.

    Protein Function

    • The function of proteins is dictated by their 3D structure.
    • The 3D structure of proteins is driven by hydrophobic interactions, ionic interactions, and hydrogen bonds.

    Enzyme Active Site

    • In the active site of the enzyme trypsin, the nucleophilic OH of Ser195 is positioned to attack the carbonyl group of a substrate.

    βE6V Mutation

    • The βE6V mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer, leading to polymerization.

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    Description

    Test your knowledge of amino acids and protein structure with this quiz. Explore the foundational work of Linus Pauling and Robert Corey, as well as the implications of mutations in clinical diagnosis and treatment.

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