Podcast
Questions and Answers
What type of mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer leading to polymerization?
What type of mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer leading to polymerization?
- Glu6 to Val6 mutation (correct)
- Val6 to Leu88 mutation
- Leu88 to Phe85 mutation
- Glu6 to Phe85 mutation
Who are the scientists credited for pioneering work in understanding the basic structural features of proteins?
Who are the scientists credited for pioneering work in understanding the basic structural features of proteins?
- John Baenziger and Linus Pauling
- Linus Pauling and John Baenziger
- Linus Pauling and Robert Corey (correct)
- Robert Corey and John Baenziger
What dictates the function of proteins according to the text?
What dictates the function of proteins according to the text?
- The presence of hydrogen bonds
- The type of RNA involved
- The 3D arrangement of amino acids (correct)
- The length of the polypeptide chain
What drives the 3D structure of proteins according to the text?
What drives the 3D structure of proteins according to the text?
In the active site of the enzyme trypsin, which group is positioned to attack the carbonyl group of a substrate?
In the active site of the enzyme trypsin, which group is positioned to attack the carbonyl group of a substrate?
What is the role of Linus Pauling and Robert Corey in our understanding of protein structure?
What is the role of Linus Pauling and Robert Corey in our understanding of protein structure?
What is the significance of the βE6V mutation in HbS?
What is the significance of the βE6V mutation in HbS?
What drives the 3D structure of proteins according to the text?
What drives the 3D structure of proteins according to the text?
What is the function of the nucleophilic OH of Ser195 in the active site of trypsin?
What is the function of the nucleophilic OH of Ser195 in the active site of trypsin?
What dictates the function of proteins according to the text?
What dictates the function of proteins according to the text?
Study Notes
Protein Structure and Function
- A point mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer, leading to polymerization.
Pioneers in Protein Structure
- Linus Pauling and Robert Corey are credited for pioneering work in understanding the basic structural features of proteins.
Protein Function
- The function of proteins is dictated by their 3D structure.
- The 3D structure of proteins is driven by hydrophobic interactions, ionic interactions, and hydrogen bonds.
Enzyme Active Site
- In the active site of the enzyme trypsin, the nucleophilic OH of Ser195 is positioned to attack the carbonyl group of a substrate.
βE6V Mutation
- The βE6V mutation in HbS creates a hydrophobic knob that fits into a hydrophobic pocket on an adjacent HbS tetramer, leading to polymerization.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test your knowledge of amino acids and protein structure with this quiz. Explore the foundational work of Linus Pauling and Robert Corey, as well as the implications of mutations in clinical diagnosis and treatment.
