Amino Acid Metabolism
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Questions and Answers

Which category of amino acids contains a benzene ring or a nonbenzene hydrocarbon chain?

  • Neutral Non-Polar (correct)
  • Acidic
  • Neutral Polar
  • Basic
  • Which amino acid contains a thiol group that can form disulfide bonds?

  • Valine
  • Cysteine (correct)
  • Glycine
  • Serine
  • Which amino acid is sometimes grouped with neutral polar amino acids, despite being borderline with respect to polarity?

  • Glycine
  • Proline
  • Cysteine (correct)
  • Valine
  • Which amino acid can be phosphorylated and has an OH group that can be a site of carbohydrate attachment?

    <p>Serine</p> Signup and view all the answers

    Which category of amino acids has a negative charge and is hydrophilic?

    <p>Acidic</p> Signup and view all the answers

    Which category of amino acids has a positive charge and is hydrophilic?

    <p>Basic</p> Signup and view all the answers

    Which amino acid is not commonly found in protein structures that require rotation, such as alpha-helices?

    <p>Proline</p> Signup and view all the answers

    Which amino acid contains sulfur and can help bind metals?

    <p>Methionine</p> Signup and view all the answers

    Which amino acid is part of many important proteins and peptides, including keratin and insulin?

    <p>Cysteine</p> Signup and view all the answers

    Which amino acid is an antioxidant, with the sequence Gly-Cys-Glu?

    <p>Cysteine</p> Signup and view all the answers

    Which of the following is NOT one of the three ways nitrogen can be incorporated into an amino acid?

    <p>Deamination</p> Signup and view all the answers

    Which coenzyme is required for transaminations to occur?

    <p>PLP</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of glutamate to glutamine in the glutamate family of amino acids?

    <p>Glutamine synthetase</p> Signup and view all the answers

    Which amino acid family shares pyruvate as a common precursor?

    <p>Pyruvate family</p> Signup and view all the answers

    Which amino acid is synthesized directly from pyruvate?

    <p>Alanine</p> Signup and view all the answers

    What is the coenzyme form of vitamin B9 (folate) that picks up the nitrogen during serine metabolism?

    <p>THF</p> Signup and view all the answers

    What can a deficiency in folate lead to?

    <p>Anemia</p> Signup and view all the answers

    Can supplementing with folate decrease the likelihood of certain cancers?

    <p>Yes</p> Signup and view all the answers

    Would it be good or bad to supplement with folate if someone already has cancer?

    <p>Bad</p> Signup and view all the answers

    Which amino acid family includes histidine?

    <p>Aromatic family</p> Signup and view all the answers

    Which of the following is a symptom of Phenylketonuria (PKU)?

    <p>Progressive mental retardation</p> Signup and view all the answers

    What is the significance of histamine in the body?

    <p>All of the above</p> Signup and view all the answers

    Where does the urea cycle occur in the body?

    <p>Liver</p> Signup and view all the answers

    Which molecule is used to start the urea cycle?

    <p>Carbamoyl phosphate</p> Signup and view all the answers

    Where does the nitrogen for urea come from?

    <p>Ammonia</p> Signup and view all the answers

    Which amino acids are both glucogenic and ketogenic?

    <p>Leucine, Phenylalanine, Tyrosine</p> Signup and view all the answers

    Which amino acid can be decarboxylated to produce histamine?

    <p>Histidine</p> Signup and view all the answers

    What is the purpose of the urea cycle?

    <p>To convert ammonia into urea for excretion</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of arginine to ornithine in the urea cycle?

    <p>Arginase</p> Signup and view all the answers

    Which part of the body has high levels of glutamine synthetase?

    <p>Liver</p> Signup and view all the answers

    Which amino acid family contains amino acids with a negative charge and is hydrophilic?

    <p>Acidic</p> Signup and view all the answers

    Which amino acid family contains amino acids with a positive charge and is hydrophilic?

    <p>Basic</p> Signup and view all the answers

    Which amino acid family contains amino acids with a benzene ring or a nonbenzene hydrocarbon chain?

    <p>Neutral Non-Polar</p> Signup and view all the answers

    Which amino acid family contains amino acids with a hydroxyl group that can be a site of carbohydrate attachment?

    <p>Neutral Polar</p> Signup and view all the answers

    Which amino acid contains a thiol group that can form disulfide bonds?

    <p>Cysteine</p> Signup and view all the answers

    Which amino acid is sometimes grouped with neutral polar amino acids, despite being borderline with respect to polarity?

    <p>Cysteine</p> Signup and view all the answers

    Which amino acid is part of many important proteins and peptides, including keratin and insulin?

    <p>Cysteine</p> Signup and view all the answers

    Which amino acid can be phosphorylated and has an OH group that can be a site of carbohydrate attachment?

    <p>Serine</p> Signup and view all the answers

    Which amino acid is not commonly found in protein structures that require rotation, such as alpha-helices?

    <p>Glycine</p> Signup and view all the answers

    Which amino acid contains a sulfur atom and can help bind metals?

    <p>Cysteine</p> Signup and view all the answers

    Which of the following is NOT a way that nitrogen can be incorporated into an amino acid?

    <p>Deamination</p> Signup and view all the answers

    Which of the following amino acids is part of the pyruvate family?

    <p>Alanine</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of glutamate to glutamine in the glutamate family of amino acids?

    <p>Glutamine synthetase</p> Signup and view all the answers

    Which amino acid is both glucogenic and ketogenic?

    <p>Lysine</p> Signup and view all the answers

    Which category of amino acids contains a benzene ring or a nonbenzene hydrocarbon chain?

    <p>Aromatic family</p> Signup and view all the answers

    What is the purpose of the urea cycle?

    <p>To convert ammonia to urea for excretion</p> Signup and view all the answers

    Which molecule is used to start the urea cycle?

    <p>Ornithine</p> Signup and view all the answers

    Which amino acid family includes histidine?

    <p>Histidine family</p> Signup and view all the answers

    Which amino acid is an antioxidant, with the sequence Gly-Cys-Glu?

    <p>Glutathione</p> Signup and view all the answers

    Which part of the body has high levels of glutamine synthetase?

    <p>Liver</p> Signup and view all the answers

    Which amino acid is both glucogenic and ketogenic?

    <p>Tyrosine</p> Signup and view all the answers

    Which amino acid is involved in the synthesis of the important electron carrier CoQ in animals?

    <p>Phenylalanine</p> Signup and view all the answers

    Which amino acid is associated with the autosomal recessive disorder Phenylketonuria (PKU)?

    <p>Phenylalanine</p> Signup and view all the answers

    Which amino acid is converted to phenylketone and excreted in urine in individuals with Phenylketonuria (PKU)?

    <p>Phenylalanine</p> Signup and view all the answers

    Which amino acid is part of the aromatic family and is only found in plants?

    <p>Tryptophan</p> Signup and view all the answers

    Which amino acid can be decarboxylated to produce histamine?

    <p>Histidine</p> Signup and view all the answers

    Which amino acid is an important precursor for the synthesis of neurotransmitters such as dopamine and norepinephrine?

    <p>Phenylalanine</p> Signup and view all the answers

    Which enzyme is responsible for the conversion of arginine to ornithine in the urea cycle?

    <p>Arginase</p> Signup and view all the answers

    Where does the urea cycle occur in the body?

    <p>Cytosol</p> Signup and view all the answers

    What is the purpose of the urea cycle?

    <p>To convert ammonia to urea for excretion</p> Signup and view all the answers

    Study Notes

    Amino Acid Categories

    • Aromatic amino acids contain a benzene ring or a nonbenzene hydrocarbon chain
    • Acidic amino acids have a negative charge and are hydrophilic
    • Basic amino acids have a positive charge and are hydrophilic

    Amino Acid Properties

    • Cysteine contains a thiol group that can form disulfide bonds
    • Tyrosine is sometimes grouped with neutral polar amino acids, despite being borderline with respect to polarity
    • Serine can be phosphorylated and has an OH group that can be a site of carbohydrate attachment
    • Glycine is not commonly found in protein structures that require rotation, such as alpha-helices
    • Methionine contains sulfur and can help bind metals
    • Cysteine is part of many important proteins and peptides, including keratin and insulin

    Amino Acid Families

    • Glutamate family shares pyruvate as a common precursor
    • Aspartate family includes aspartate and asparagine
    • Histidine family includes histidine
    • Pyruvate family includes alanine, valine, and leucine

    Urea Cycle

    • Occurs in the liver and kidney
    • Purpose is to remove ammonia from the body
    • Starts with the molecule ammonia
    • Nitrogen for urea comes from ammonia
    • Arginine is converted to ornithine in the urea cycle by the enzyme ornithine transcarbamylase
    • Ornithine is then converted to citrulline

    Other Amino Acids

    • Glutamine is an important precursor for the synthesis of neurotransmitters such as dopamine and norepinephrine
    • Phenylalanine is associated with the autosomal recessive disorder Phenylketonuria (PKU)
    • Tyrosine can be decarboxylated to produce histamine
    • Glutamine synthetase is found in high levels in the brain

    Vitamin B9 (Folate)

    • Coenzyme form is tetrahydrofolate (THF)
    • Picks up nitrogen during serine metabolism
    • Deficiency in folate can lead to anemia and birth defects
    • Supplementing with folate can decrease the likelihood of certain cancers
    • However, it is not recommended to supplement with folate if someone already has cancer

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    Description

    Test your knowledge of amino acid classifications! This quiz will challenge you to categorize amino acids based on their polarity, describe the properties of each category, and identify any unique groups. Can you match the 3-letter and 1-letter codes to the correct amino acids? Put your skills to the test with this amino acid classification quiz!

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