12 Questions
At what estimated number of years before diagnosis did the CSF biomarker concentrations in the Alzheimer's disease group diverge from those in the cognitively normal group for amyloid-beta (Aβ)42?
18 years
Which CSF biomarker showed divergence between the Alzheimer's disease group and the cognitively normal group approximately 10 years before diagnosis?
Total tau
What type of assessments were conducted at 2-year-to-3-year intervals on a subgroup of participants in the study?
Cognitive assessments
When did the changes in CSF biomarker levels in the Alzheimer's disease group initially accelerate?
Close to diagnosis
How many participants who developed Alzheimer's disease were matched with participants who had normal cognition in the study?
648 participants
At what estimated number of years before diagnosis did hippocampal volume begin to show divergence between the two groups?
8 years
What was the estimated number of years before diagnosis when neurofilament light chain levels started to show divergence between the Alzheimer's disease group and the cognitively normal group?
9 years
At what estimated number of years before diagnosis did the ratio of amyloid-beta (Aβ)42 to Aβ40 begin to show divergence between the two groups?
14 years
When did the cognitive decline in the Alzheimer's disease group start to accelerate according to the study findings?
6 years before diagnosis
At what estimated number of years before diagnosis did phosphorylated tau 181 levels diverge between the Alzheimer's disease group and the cognitively normal group?
10 years
What was the median follow-up duration in the study as reported in the text?
19.9 years
After how many years before diagnosis did total tau levels in the Alzheimer's disease group show divergence from those in the cognitively normal group?
10 years
Explore a multicenter, nested case-control study investigating Alzheimer's disease biomarkers in cognitively normal participants. Learn about the China Cognition and Aging Study and the testing of cerebrospinal fluid (CSF) biomarkers.
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