Alzheimer's Disease and Dementia
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Questions and Answers

What is the primary focus of AD biomarker research in CSF and brain tissues?

  • Studying the effects of oxidative stress
  • Analyzing the role of calcium homeostasis
  • Identifying markers of neuronal damage
  • Understanding β-amyloid metabolism (correct)

    • What is the goal of recent metabolomic research in AD biomarkers?

  • To understand the role of Apolipoprotein E gene APOEε4
  • To develop a cure for AD
  • To study the effects of lipid metabolism on AD
  • To identify prognostic indicators and elucidate biological mechanisms (correct)

    • What was the primary finding in the study evaluating metabolites in AD patients and control subjects?

  • Triglycerides and amines were increased in AD patients
  • Age and gender-dependent differences in β-amyloid levels
  • Age and gender-dependent differential metabolic expression (correct)
  • Sphingomyelin was decreased in AD patients

    • Which compound was identified as a regulatory marker and strong predictor for AD in the study?

    <p>Lysophosphatidic acid (LPA) C18:2</p> Signup and view all the answers

    What was the significance of the study's findings on Apolipoprotein E gene APOEε4-positive AD?

    <p>It proposed oxidative stress compounds as regulatory markers for AD</p> Signup and view all the answers

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