10 Questions
What percentage of ALS cases are familial?
10%
What is the primary method of diagnosis for ALS?
Clinical observation
What is a known pathophysiological mechanism in ALS?
Oxidative stress
What is a characteristic of ALS?
Progressive generalized paresis
What is a goal of using metabolomics in ALS research?
To improve diagnosis and prognosis
What was the primary goal of the study that profiled 12 elevated compounds associated with the benzothiazole drug class?
To understand the metabolic signature of MND patients
What is the most consistent finding in metabolomic studies of patients with ALS?
Elevated levels of glutamate in the blood
What is the proposed imbalance in the metabolic cycle of ALS patients according to one study?
Glutamate–glutamine conversion cycle
What is the difference in metabolomic profile between sporadic and familial ALS patients?
Familial ALS has a more distinguishable metabolomic profile
What is the potential indicator of abnormal CNS energy metabolism in ALS patients?
Decreased levels of creatinine in the CSF
Learn about Amyotrophic Lateral Sclerosis, a fatal neurodegenerative disease that affects motor neurons. Understand its characteristics, diagnosis, and effects on the body. Test your knowledge of this devastating condition!
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