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ALS Disease Overview

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Questions and Answers

What percentage of ALS cases are familial?

10% (correct)

30%

20%

What is the primary method of diagnosis for ALS?

Lab tests

Genetic testing

Imaging techniques

Clinical observation (correct)

What is a known pathophysiological mechanism in ALS?

Inflammation

Oxidative stress (correct)

Nutrient deficiency

Hormonal imbalance

What is a characteristic of ALS?

Progressive generalized paresis Signup and view all the answers

What is a goal of using metabolomics in ALS research?

To improve diagnosis and prognosis Signup and view all the answers

What was the primary goal of the study that profiled 12 elevated compounds associated with the benzothiazole drug class?

To understand the metabolic signature of MND patients Signup and view all the answers

What is the most consistent finding in metabolomic studies of patients with ALS?

Elevated levels of glutamate in the blood Signup and view all the answers

What is the proposed imbalance in the metabolic cycle of ALS patients according to one study?

Glutamate–glutamine conversion cycle Signup and view all the answers

What is the difference in metabolomic profile between sporadic and familial ALS patients?

Familial ALS has a more distinguishable metabolomic profile Signup and view all the answers

What is the potential indicator of abnormal CNS energy metabolism in ALS patients?

Decreased levels of creatinine in the CSF Signup and view all the answers