Alpha-Beta Adrenergic Agonists: Dopamine and Isoproterenol
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Questions and Answers

Dopamine, an alpha-beta adrenergic agonist, is used in the treatment of shock primarily for what reason?

  • To inhibit the release of norepinephrine, thus reducing stress on the heart.
  • To directly counteract the effects of pulmonary hypertension.
  • To induce tachyarrhythmias to improve cardiac output.
  • To dilate vessels in the kidneys, maintaining perfusion, and to stimulate the sympathetic nervous system. (correct)

A patient with which of the following conditions would be contraindicated for dopamine administration?

  • Pheochromocytoma (correct)
  • Hypovolemia due to blood loss
  • Bradycardia
  • Hypotension

What is the primary mechanism of action of Isoproterenol?

  • Acts on nicotinic receptors to produce increased HR, positive inotropic effect, bronchodilation and vasodilation
  • Acts on beta-adrenergic receptors to produce increased HR, positive inotropic effect, bronchodilation, and vasodilation. (correct)
  • Acts on alpha-adrenergic receptors to decrease HR, negative inotropic effect and vasoconstriction
  • Acts on muscarinic receptors to produce increased HR, positive inotropic effect, bronchodilation and vasodilation

Which of the following is a contraindication for the use of Isoproterenol?

<p>Pulmonary Hypertension (A)</p> Signup and view all the answers

What is the half-life of dopamine?

<p>2 minutes (D)</p> Signup and view all the answers

A patient is experiencing symptoms of shock. Which assessment finding would lead the nurse to question the administration of dopamine?

<p>Heart rate of 160 bpm (B)</p> Signup and view all the answers

A patient receiving Isoproterenol starts to complain of chest pain and shortness of breath. What is the priority nursing intervention?

<p>Notify the healthcare provider and prepare to administer oxygen. (D)</p> Signup and view all the answers

If a patient is concurrently taking an antidepressant, what is a significant concern regarding the administration of dopamine?

<p>Potential for hypertensive crisis. (B)</p> Signup and view all the answers

Which of the following adverse effects is more commonly associated with Isoproterenol than with Dopamine, considering their receptor specificities?

<p>Anxiety and tremors, due to predominant beta-adrenergic stimulation. (D)</p> Signup and view all the answers

Flashcards

Alpha-Beta Adrenergic Agonist

A drug that stimulates both alpha and beta-adrenergic receptors; used to treat shock by dilating kidney vessels and stimulating the sympathetic nervous system.

Dopamine Indications

Correction of hemodynamic imbalances in shock through vasodilation in the kidneys and stimulation of the sympathetic nervous system.

Dopamine Contraindications

Pheochromocytoma, tachyarrhythmias, ventricular fibrillation, hypovolemia, and peripheral vascular disease.

Dopamine Adverse Effects

Tachycardia, ectopic beats, anginal pain, and dyspnea.

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Dopamine Drug Interactions

Antidepressants and MAOIs

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Beta-Specific Adrenergic Agonist

A drug that specifically acts on beta-adrenergic receptors to increase heart rate, contractility, bronchodilation, and vasodilation.

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Isoproterenol Indications

Shock with low cardiac output, cardiac arrest, ventricular arrhythmias, and heart block.

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Isoproterenol Contraindications

Pulmonary hypertension, tachyarrhythmias, diabetes, thyroid disease, heart disease, and stroke.

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Isoproterenol Adverse Effects

Anxiety, fear, cardiac arrhythmias, tachycardia, nausea/vomiting, heartburn, respiratory difficulties, coughing, pulmonary edema, and sweating.

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Study Notes

  • Alpha-Beta adrenergic agonists such as Dopamine treat shock

Dopamine

  • Acts directly or triggers norepinephrine release.
  • Dilates kidney vessels to sustain perfusion while stimulating the sympathetic nervous system.
  • Used for correcting hemodynamic imbalances during instances of shock.
  • Should not be used with Pheochromocytoma.
  • Contraindicated in patients with tachyarrhythmias or ventricular fibrillation.
  • Use is cautioned with hypovolemia and peripheral vascular disease.
  • Adverse effects include tachycardia, ectopic beats, anginal pain, and dyspnea.
  • Administered via IV.
  • Has a half-life of 2 minutes.
  • Do not use with antidepressants and MAOIs.

Isoproterenol

  • Functions as a beta-specific adrenergic agonist which enhances heart pumping.
  • Acts on beta-adrenergic receptors, increasing heart rate, providing a positive inotropic effect, causing bronchodilation, and vasodilation.
  • Indicated for shock with low cardiac output, cardiac arrest, ventricular arrhythmias, and heart block.
  • Contraindicated in patients with pulmonary hypertension and tachyarrhythmias.
  • Use is cautioned with diabetes, thyroid disease, heart disease, and stroke.
  • Adverse effects include anxiety, fear, cardiac arrhythmias, tachycardia, nausea/vomiting, heartburn, respiratory difficulties, coughing, pulmonary edema, and sweating.
  • Administered via IV.

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Description

An overview of Dopamine and Isoproterenol. Dopamine helps correct hemodynamic imbalances during shock by dilating kidney vessels and stimulating the sympathetic nervous system. Isoproterenol increases heart rate, provides inotropic effects, and causes bronchodilation.

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