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Questions and Answers
What is the primary mechanism of action for non-selective alpha adrenergic antagonists?
What is the primary mechanism of action for non-selective alpha adrenergic antagonists?
- Activating alpha-1 receptors
- Selectively blocking alpha-2 receptors
- Blocking both alpha-1 and alpha-2 receptors (correct)
- Selectively blocking alpha-1 receptors
Which non-selective alpha adrenergic antagonist is FDA-approved?
Which non-selective alpha adrenergic antagonist is FDA-approved?
- Terazosin
- Phenoxybenzamine
- Prazosin
- Phentolamine (correct)
What is a primary indication for using Phentolamine?
What is a primary indication for using Phentolamine?
- Prevention of dermal necrosis from catecholamine extravasation (correct)
- Management of heart failure
- Treatment of hypertension
- Lowering cholesterol
Which of the following is a contraindication for using non-selective alpha adrenergic antagonists?
Which of the following is a contraindication for using non-selective alpha adrenergic antagonists?
What is a common adverse effect associated with non-selective alpha adrenergic antagonists?
What is a common adverse effect associated with non-selective alpha adrenergic antagonists?
Which drug's effect is decreased when administered with non-selective alpha adrenergic antagonists?
Which drug's effect is decreased when administered with non-selective alpha adrenergic antagonists?
What is a potential effect of combining alcohol with non-selective alpha adrenergic antagonists?
What is a potential effect of combining alcohol with non-selective alpha adrenergic antagonists?
Non-selective alpha adrenergic antagonists are cautioned in which condition related to women's health?
Non-selective alpha adrenergic antagonists are cautioned in which condition related to women's health?
Besides preventing dermal necrosis, what other condition can Phentolamine reverse?
Besides preventing dermal necrosis, what other condition can Phentolamine reverse?
Which of the following is an extension of therapeutic effects that could become an adverse effect?
Which of the following is an extension of therapeutic effects that could become an adverse effect?
Flashcards
Non-Selective Alpha Adrenergic Antagonists: Mechanism of Action
Non-Selective Alpha Adrenergic Antagonists: Mechanism of Action
Block both alpha-1 and alpha-2 receptors, leading to vasodilation and decreased blood pressure.
Phentolamine
Phentolamine
Only FDA-approved agent in the non-selective alpha adrenergic antagonists class.
Indications of Non-Selective Alpha Adrenergic Antagonists
Indications of Non-Selective Alpha Adrenergic Antagonists
Prevent dermal necrosis secondary to catecholamine extravasation (epinephrine or norepinephrine) and reversal of soft-tissue anesthesia.
Contraindications of Non-Selective Alpha Adrenergic Antagonists
Contraindications of Non-Selective Alpha Adrenergic Antagonists
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Adverse Effects of Non-Selective Alpha Adrenergic Antagonists
Adverse Effects of Non-Selective Alpha Adrenergic Antagonists
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Drug Interactions with Non-Selective Alpha Adrenergic Antagonists
Drug Interactions with Non-Selective Alpha Adrenergic Antagonists
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Study Notes
- Non-selective alpha-adrenergic antagonists block both alpha-1 and alpha-2 receptors.
- Phentolamine is the only FDA-approved agent in this class.
- These agents prevent dermal necrosis secondary to catecholamine extravasation (epinephrine or norepinephrine).
- They also facilitate the reversal of soft-tissue anesthesia.
- Contraindications include coronary artery disease (CAD), myocardial infarction (MI), pregnancy, and lactation.
- Adverse effects are extensions of therapeutic effects like headache, weakness, and dizziness due to hypotension, nausea, vomiting, and diarrhea.
- Drug interactions include ephedrine and epinephrine, where the antagonist blocks the receptors and decreases their effect, and alcohol.
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