Allosteric Regulation of Glycogen Metabolism

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Questions and Answers

In the context of glucose metabolism, what is the primary function of insulin in the liver?

  • Stimulates glycogenesis (correct)
  • Blocks glycogenolysis
  • Activates glucagon receptors
  • Promotes pentose phosphate pathway

Which pathway runs alongside glycolysis/gluconeogenesis and produces monosaccharides, NADPH, and antioxidants?

  • Insulin Signaling
  • Glycogenesis
  • Pentose Phosphate Pathway (correct)
  • Glycogenolysis

Which hormone has a direct effect of promoting glycogenolysis in muscle tissue?

  • Insulin in liver
  • Glucagon in muscle (correct)
  • Insulin in muscle
  • Epinephrine in liver

What is the main function of NADPH in the Pentose Phosphate Pathway?

<p>Provides reducing power (electrons) for biosynthesis (B)</p> Signup and view all the answers

Which phase of the Pentose Phosphate Pathway generates pentoses and produces NADPH?

<p>Oxidative Phase (B)</p> Signup and view all the answers

What is the main outcome of the autophosphorylation process in insulin signaling?

<p>Activation of Akt (PKB) (C)</p> Signup and view all the answers

How is the first step of the Pentose Phosphate Pathway regulated?

<p>By levels of NADP+ (D)</p> Signup and view all the answers

During glycogenesis, what is the primary role of Akt (PKB) activated by insulin?

<p>Stimulates storage of glucose as glycogen (C)</p> Signup and view all the answers

Which of the following hormones is involved in blocking glycogenolysis by stimulating PP1?

<p>Insulin (C)</p> Signup and view all the answers

Which pathway involves the conversion of monosaccharides to hexoses for entry into glycolysis?

<p>Pentose Phosphate Pathway (C)</p> Signup and view all the answers

What key process is described by the insulin signaling cascade upon ligand binding?

<p>Autophosphorylation of Akt (PKB) (D)</p> Signup and view all the answers

What can be oxidized into CO2 according to the text?

<p>Carbohydrates (A)</p> Signup and view all the answers

What determines whether glycogen synthase is active or not?

<p>Phosphorylation (C)</p> Signup and view all the answers

Which enzyme phosphorylates glycogen synthase, leading to its inactivation?

<p>GSK-3 (C)</p> Signup and view all the answers

What activates glycogen phosphorylase?

<p>Dephosphorylation (D)</p> Signup and view all the answers

Which molecule deactivates glycogen phosphorylase?

<p>PP1 (B)</p> Signup and view all the answers

In the context of glycogen metabolism, what is the role of PKA?

<p>Activates glycogen phosphorylase (C)</p> Signup and view all the answers

Which enzyme is responsible for the breakdown of glycogen in a process called glycogenolysis?

<p>Glycogen phosphorylase (A)</p> Signup and view all the answers

What is the role of UTP in the synthesis of glycogen?

<p>Activating glucose for further metabolism (C)</p> Signup and view all the answers

Which enzyme acts as a branch point in the glycogen structure?

<p>Branching enzyme (C)</p> Signup and view all the answers

What is the main regulator of both Glycogen phosphorylase and Glycogen synthase?

<p>PKA (A)</p> Signup and view all the answers

Which process involves breaking down glycogen molecule one glucose at a time?

<p>Glycogenolysis (A)</p> Signup and view all the answers

Which component serves as a core protein and an enzyme in glycogen synthesis?

<p>Glycogenin (D)</p> Signup and view all the answers

What is the primary function of glycogen?

<p>To store glucose monomers (C)</p> Signup and view all the answers

Which enzyme is responsible for the synthesis of glycogen?

<p>Glycogen synthase (B)</p> Signup and view all the answers

What is the role of epinephrine and norepinephrine in regulating glycogen storage?

<p>Activate enzymes for glycogenolysis (A)</p> Signup and view all the answers

Which of the following statements about glycogenolysis is true?

<p>It is stimulated by glucagon and inhibited by insulin (D)</p> Signup and view all the answers

In which pathway do we find reactions that generate ribose-5-phosphate?

<p>Pentose phosphate pathway (C)</p> Signup and view all the answers

How does insulin signaling affect glycogen metabolism?

<p>Activates glycogen synthase to promote glycogenesis (A)</p> Signup and view all the answers

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