Allergy and Lung Regulation Quiz
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Questions and Answers

Which immunoglobulin is primarily involved in Type I hypersensitivity reactions?

  • IgD
  • IgM
  • IgA
  • IgE (correct)
  • IgG antibodies are primarily produced at the onset of an infection.

    False (B)

    What substance is predominantly released during a Type I hypersensitivity reaction?

    Histamine

    IgA is expressed in _______ tissue and helps protect the neonatal gut.

    <p>mucosal</p> Signup and view all the answers

    Match the following immunoglobulins with their primary functions:

    <p>IgG = Highly specific antibodies targeting single epitopes IgA = Protects the neonatal gut and is expressed in mucosal tissue IgM = Circulating tetramers made at the beginning of infection IgE = Implicated in allergy and response to parasitic threats IgD = Induces antibodies in B cells and activates basophils and mast cells</p> Signup and view all the answers

    What is the hormone released by sympathetic nerve fibres?

    <p>Noradrenaline (C)</p> Signup and view all the answers

    Parasympathetic stimulation causes relaxation of airway smooth muscle.

    <p>False (B)</p> Signup and view all the answers

    Which neurotransmitter is involved in parasympathetic regulation of airway smooth muscle?

    <p>Acetylcholine</p> Signup and view all the answers

    Beta-2 adrenergic receptors cause ______ of smooth muscle and bronchodilation.

    <p>relaxation</p> Signup and view all the answers

    Match the types of anti-muscarinics to their descriptions:

    <p>Short-acting anti-muscarinics = E.g., ipratropium bromide Long-acting anti-muscarinics = E.g., tiotropium</p> Signup and view all the answers

    What initiates a type II hypersensitivity reaction?

    <p>Previously formed antibodies reacting with antigens on host cell membranes (A)</p> Signup and view all the answers

    Goodpasture syndrome involves the lungs as one of its primary organs affected.

    <p>True (A)</p> Signup and view all the answers

    What antibodies are usually involved in type II hypersensitivity reactions?

    <p>IgG or IgM</p> Signup and view all the answers

    The primary antigen causing Goodpasture syndrome is the _____ subunit of type IV collagen.

    <p>Alpha-3</p> Signup and view all the answers

    Match the outcomes of complement activation in Type II hypersensitivity with their effects:

    <p>Cell lysis = Myasthenia Opsonisation and phagocytosis = Autoimmune hemolysis Neutrophil activation and tissue damage = Anti-GBM disease Metabolic activation = Graves’ disease</p> Signup and view all the answers

    Which of the following is an example of a Type II hypersensitivity reaction?

    <p>Haemolytic disease of the newborn (A)</p> Signup and view all the answers

    Type II hypersensitivity primarily involves the kidneys and heart.

    <p>False (B)</p> Signup and view all the answers

    What type of hypersensitivity reaction is Anti-Glomerular Basement Membrane (aGBM) disease?

    <p>Type II</p> Signup and view all the answers

    The main components of the glomerular basement membrane include type _____ collagen.

    <p>IV</p> Signup and view all the answers

    What functional activity occurs in Type II hypersensitivity?

    <p>Metabolic activation (B)</p> Signup and view all the answers

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    Flashcards

    What does the sympathetic nervous system regulate?

    The fight-or-flight response is triggered by the sympathetic nervous system, preparing the body for immediate action.

    What hormone is released by sympathetic nerve fibers?

    Noradrenaline is a neurotransmitter released by sympathetic nerve fibers, acting as a chemical messenger in the nervous system, especially during stress and excitement.

    Which receptors are activated by noradrenaline?

    Adrenergic receptors are a type of cell surface receptor that bind noradrenaline, triggering a physiological response, like increased heart rate or dilation of airways.

    What are the two types of adrenergic receptors?

    Alpha and beta adrenergic receptors are two main types of receptors that respond to noradrenaline, each triggering different physiological effects.

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    Where are the adrenergic receptors located in the respiratory system?

    Beta-2 adrenergic receptors are located in the smooth muscles of the airways, and when activated by noradrenaline, they cause relaxation of the airway muscles, leading to bronchodilation.

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    What is IgG?

    The most common type of antibody found in blood and lymph. It helps fight bacterial infections and viruses.

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    What is IgA?

    This antibody is found in mucosal tissues like the gut and lungs. It protects against infections and helps prevent pathogens from entering the body. It also plays a role in protecting newborns through breast milk.

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    What is IgM?

    This antibody forms as a pentamer. It is the first antibody produced during an infection and helps to neutralize pathogens.

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    What is IgE?

    This antibody, also called reagin, is mostly found in blood and tissues. It has a high affinity for mast cells. It is important in the response to parasitic infections and allergic reactions.

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    What is IgD?

    This antibody is found on the surface of B cells. It helps to activate the immune response and aids in the production of other antibodies.

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    What is an allergy?

    A type of immune response where the body overreacts to a harmless substance, like pollen, food, or medication.

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    What is anaphylaxis?

    A severe, life-threatening allergic reaction that can cause swelling, difficulty breathing, and a drop in blood pressure.

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    What is Type II hypersensitivity?

    A type of hypersensitivity reaction where antibodies attack the body's own cells.

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    How does Type II hypersensitivity work?

    It involves antibodies binding to antigens on the surface of cells, leading to cell destruction.

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    What are some examples of Type II hypersensitivity?

    Autoimmune diseases, where the immune system attacks healthy tissues, are examples of Type II hypersensitivity reactions.

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    What is Anti-Glomerular Basement Membrane (aGBM) disease?

    A condition where antibodies attack the glomerular basement membrane in the kidneys, leading to kidney damage.

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    What is Goodpasture syndrome?

    Goodpasture syndrome is an autoimmune disease where antibodies attack the glomerular basement membrane in the kidneys and the alveoli in the lungs.

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    What is the composition of the glomerular basement membrane?

    Type IV collagen is a major component of the glomerular basement membrane, the structure that filters waste in the kidneys.

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    What is the antigen in Goodpasture syndrome?

    The alpha-3 subunit of type IV collagen is the specific antigen that triggers the immune response in Goodpasture syndrome.

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    What mediates Type III hypersensitivity?

    Immune complexes, formed by the binding of antigens and antibodies, trigger Type III hypersensitivity.

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    Study Notes

    Allergy, Hypersensitivity, and the Lung

    • Sympathetic Regulation:
      • The sympathetic nervous system regulates the "fight-or-flight" response.
      • A hormone released by sympathetic nerve fibers is noradrenaline.
      • Noradrenaline activates adrenergic receptors.
      • Two types of adrenergic receptors are alpha and beta.
      • Airway smooth muscle cells have beta adrenergic receptors.
      • Sympathetic stimulation of beta-2 receptors on airway smooth muscle causes muscle relaxation and bronchodilation.
      • Activation of beta-2 receptors causes muscle relaxation by activating adenylate cyclase, increasing cyclic AMP.

    Parasympathetic Regulation

    • Neurotransmitter: The neurotransmitter released by post-synaptic parasympathetic nerve fibers to regulate airway smooth muscle is acetylcholine.
    • Effect on Smooth Muscle: Parasympathetic stimulation causes smooth muscle constriction.
    • Receptors: Acetylcholine acts on muscarinic receptors (M1-5), specifically the M3 subtype, on smooth muscle cells.
    • Anti-muscarinics: Anti-muscarinics block parasympathetic activity by blocking receptors, such as M3 receptors.
    • Types of Anti-muscarinics: Different types of anti-muscarinics exist.

    Hypersensitivity Types and Descriptors

    • Type I:
      • Mediated by IgE antibodies, resulting in an immediate response (within 1 hour).
      • Examples include anaphylaxis, hay fever, and asthma.
      • Triggered when an antigen binds to IgE antibodies attached to mast cells or basophils, causing the release of mediators like histamine, leading to inflammation.
    • Type II:
      • Cytotoxic hypersensitivity, involving antibodies (IgG or IgM) targeting the host's own cells or foreign cells.
      • Outcomes depend on complement activation and cell metabolism.
      • Examples include autoimmune diseases like Graves' disease and Goodpasture's disease or Rh incompatibility.
    • Type III:
      • Immune complex hypersensitivity, where antibodies combine with antigens to form immune complexes that deposit in tissues.
      • This triggers inflammation, such as in serum sickness or hypersensitivity pneumonitis.
    • Type IV:
      • Cell-mediated hypersensitivity, involving T cells and cytokines.
      • Mediated by a delayed response (2-3 days).
      • Examples include contact dermatitis, the tuberculin skin test, and tissue rejection.

    Antibodies Description

    • Antibodies are produced by B-lymphocytes (plasma cells).
    • Their role is to neutralize or eliminate pathogens.
    • Five types of antibodies exist: IgG, IgA, IgM, IgE, and IgD.
    • IgG: mononmers highly specific for single epitopes.
    • IgA: found in mucosal tissues, protecting the neonatal gut.
    • IgM: circulating tetramers produced at the beginning of an infection.
    • IgE: linked to parasitic threats and allergies, often in conjunction with eosinophils.
    • IgD: monomers involved in the activation of mast and basophil cells.

    Hypersensitivity Type I

    • Initiation: Antigen interaction with IgE bound to mast cells or basophils.
    • Timing: Immediate (within 1 hour).

    Hypersensitivity Type I Reactions

    • Examples: Anaphylaxis, allergies (food, drugs, pollens, pet dander), and allergic bronchial asthma.

    Hypersensitivity Type II

    • Mechanism: Antibodies (IgG or IgM) binding to antigens on host-cell membranes, leading to cell destruction.

    Hypersensitivity Type III

    • Mediation: Formation of antibody-antigen complexes.
    • Antibody Types: Mainly IgG or IgM.
    • Precipitates: Immune complexes are deposited in various tissues (e.g., skin, joints, vessels, glomeruli).
    • Pathway Triggered: Classical complement pathway.
    • Outcome: Triggers inflammation due to complement activation and recruitment of inflammatory cells, like monocytes and neutrophils).

    Hypersensitivity Type IV

    • Mediators: T-cells releasing cytokines (e.g., IL-2, IFN-γ).
    • Requirement: Primary sensitization to the antigen is needed.
    • Delay: 2-3 days.
    • Consequences of Macrophage Failure: Macrophages may fuse to form giant cells, leading to granuloma formation where they can't destroy the pathogen.

    Examples of hypersensitivity Type IV Reactions

    • Contact dermatitis, Tuberculosis skin test, tissue rejection

    Case Studies (Specific examples from the provided texts)

    • Case 1 (Type I): 18-year-old male experiencing anaphylaxis to peanuts.
    • Case 2 (Type II): 45-year-old female with haemoptysis due to Anti-Glomerular Basement Membrane disease.
    • Case 3 (Type III): Hypersensitivity pneumonitis caused by inhaled antigens (e.g., from moldy hay).
    • Case 4 (Type IV): 53-year-old man with sarcoidosis potentially due to a reaction to mycobacteria.

    Treatments for Hypersensitivity Pneumonitis

    • Removal of the triggering antigen, and if needed immunosuppression.

    Diagnosing Hypersensitivity Pneumonitis

    • Mantoux/Tuberculin skin test. (Detailed steps for test procedure are provided in the text.)

    Diagnostics of Hypersensitivity reactions (more general information):

    • Details on what types of antigens and antibodies are associated with each type of hypersensitivity reaction are in the text.

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    Description

    Test your knowledge on the dynamic regulation of airway smooth muscle by the sympathetic and parasympathetic nervous systems. This quiz covers aspects such as adrenergic and muscarinic receptors, as well as the associated neurotransmitters and hormones involved in respiratory physiology.

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