Allergic Reactions and Anaphylaxis Pharmacotherapy

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Questions and Answers

What is the main trigger for histamine release from mast cells in allergic reactions?

  • IgE (correct)
  • IgG
  • IgM
  • IgA

Which receptor type does histamine act on to cause bronchodilatation and vasoconstriction?

  • H3 receptors
  • H1 receptors (correct)
  • H4 receptors
  • H2 receptors

What is the primary pharmacological action of epinephrine in the treatment of anaphylaxis?

  • Vasodilation
  • Bronchoconstriction
  • Vasoconstriction (correct)
  • Anti-inflammatory effects

Why is early administration of corticosteroids important in anaphylaxis management?

<p>To inhibit the 2nd phase of anaphylaxis (C)</p> Signup and view all the answers

Which pharmacological agent is NOT a substitute for epinephrine in the treatment of anaphylaxis?

<p>Salbutamol (D)</p> Signup and view all the answers

What is the main benefit of administering Epi-Pen or Ana-Pen devices in anaphylactic emergencies?

<p>Allows emergency medication without a prescription (D)</p> Signup and view all the answers

What is the mechanism of anaphylaxis?

<p>Type I hypersensitivity reaction mediated by IgE antibodies (C)</p> Signup and view all the answers

Which of the following is NOT a common allergen responsible for milder allergic reactions?

<p>Protein in drugs (A)</p> Signup and view all the answers

In allergic rhinitis, which of the following can cause symptoms like nasal congestion and mild wheezing?

<p>House dust mite dander (D)</p> Signup and view all the answers

Which immunoglobulin is mainly involved in Type I hypersensitivity reactions?

<p>IgE (B)</p> Signup and view all the answers

What is a characteristic symptom of atopic dermatitis?

<p>Skin rashes (C)</p> Signup and view all the answers

What is the central role of histamine release in mild allergic reactions?

<p>Increased capillary permeability (D)</p> Signup and view all the answers

Which cells store histamine in granules and release it upon exposure to allergens?

<p>Mast cells (A)</p> Signup and view all the answers

In hypersensitivity type I reactions, what binds to Fc receptors on mast cells?

<p>Immunoglobulin E (IgE) (B)</p> Signup and view all the answers

What is the main cause of histamine-induced bronchoconstriction in anaphylactic reactions?

<p>Bronchospasm (B)</p> Signup and view all the answers

Which receptors are present on bronchial smooth muscle and endothelial cells, leading to various effects upon activation?

<p>H1 receptors (A)</p> Signup and view all the answers

In systemic allergy like anaphylaxis, what leads to hypotension and cardiovascular collapse?

<p>Increased capillary leakage of plasma (C)</p> Signup and view all the answers

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