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Allergic Reactions and Anaphylaxis Pharmacotherapy
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Allergic Reactions and Anaphylaxis Pharmacotherapy

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Questions and Answers

What is the main trigger for histamine release from mast cells in allergic reactions?

  • IgE (correct)
  • IgG
  • IgM
  • IgA
  • Which receptor type does histamine act on to cause bronchodilatation and vasoconstriction?

  • H3 receptors
  • H1 receptors (correct)
  • H4 receptors
  • H2 receptors
  • What is the primary pharmacological action of epinephrine in the treatment of anaphylaxis?

  • Vasodilation
  • Bronchoconstriction
  • Vasoconstriction (correct)
  • Anti-inflammatory effects
  • Why is early administration of corticosteroids important in anaphylaxis management?

    <p>To inhibit the 2nd phase of anaphylaxis</p> Signup and view all the answers

    Which pharmacological agent is NOT a substitute for epinephrine in the treatment of anaphylaxis?

    <p>Salbutamol</p> Signup and view all the answers

    What is the main benefit of administering Epi-Pen or Ana-Pen devices in anaphylactic emergencies?

    <p>Allows emergency medication without a prescription</p> Signup and view all the answers

    What is the mechanism of anaphylaxis?

    <p>Type I hypersensitivity reaction mediated by IgE antibodies</p> Signup and view all the answers

    Which of the following is NOT a common allergen responsible for milder allergic reactions?

    <p>Protein in drugs</p> Signup and view all the answers

    In allergic rhinitis, which of the following can cause symptoms like nasal congestion and mild wheezing?

    <p>House dust mite dander</p> Signup and view all the answers

    Which immunoglobulin is mainly involved in Type I hypersensitivity reactions?

    <p>IgE</p> Signup and view all the answers

    What is a characteristic symptom of atopic dermatitis?

    <p>Skin rashes</p> Signup and view all the answers

    What is the central role of histamine release in mild allergic reactions?

    <p>Increased capillary permeability</p> Signup and view all the answers

    Which cells store histamine in granules and release it upon exposure to allergens?

    <p>Mast cells</p> Signup and view all the answers

    In hypersensitivity type I reactions, what binds to Fc receptors on mast cells?

    <p>Immunoglobulin E (IgE)</p> Signup and view all the answers

    What is the main cause of histamine-induced bronchoconstriction in anaphylactic reactions?

    <p>Bronchospasm</p> Signup and view all the answers

    Which receptors are present on bronchial smooth muscle and endothelial cells, leading to various effects upon activation?

    <p>H1 receptors</p> Signup and view all the answers

    In systemic allergy like anaphylaxis, what leads to hypotension and cardiovascular collapse?

    <p>Increased capillary leakage of plasma</p> Signup and view all the answers

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