Questions and Answers
What drug class is aliskiren?
What is the MOA of aliskiren?
Binds tightly with renin to inhibit the entire RAAS
What are indications of aliskiren?
Hypertension
What are side effects of aliskiren? (Select all that apply)
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When is hyperkalemia more of a risk for a patient?
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What are contraindications of aliskiren?
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What are drug-drug interactions of aliskiren? (Select all that apply)
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Study Notes
Aliskiren Overview
- Aliskiren is classified as a direct renin inhibitor, targeting the renin-angiotensin-aldosterone system (RAAS).
- It effectively reduces hypertension by preventing the conversion of angiotensinogen to angiotensin I.
Mechanism of Action (MOA)
- Aliskiren binds tightly to renin, leading to the inhibition of the entire RAAS pathway. This results in decreased levels of angiotensin II, which contributes to blood pressure regulation.
Indications
- Primarily indicated for the treatment of hypertension.
Side Effects
- Common side effects include:
- Diarrhea
- Hyperkalemia (increased potassium levels)
- Angioedema (swelling of the deeper layers of the skin)
Risk Factors for Hyperkalemia
- The risk of hyperkalemia increases when aliskiren is used concurrently with ACE inhibitors or spironolactone, as these medications also affect potassium levels.
Contraindications
- Aliskiren is contraindicated in pregnancy due to potential harm to the developing fetus.
Drug-Drug Interactions
- Notable interactions include:
- Lasix (furosemide), a diuretic that may affect aliskiren's efficacy.
- Atorvastatin, a cholesterol-lowering medication that could alter the pharmacokinetics of aliskiren.
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Description
This quiz focuses on Aliskiren, a direct renin inhibitor used for hypertension. Review important aspects such as its mechanisms of action, indications, and side effects through flashcards. Perfect for pharmacy students and healthcare professionals.
