Questions and Answers
What is Tekturna?
What are the dosage forms of Tekturna?
Tablet-oral
What is the indication for Tekturna?
High blood pressure
What is the mechanism of action of Tekturna?
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What are the pharmacokinetics of Tekturna?
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What monitoring parameters should be observed while taking Tekturna?
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Which of the following are drug interactions with Tekturna? (Select all that apply)
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What are the adverse reactions associated with Tekturna?
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What are the contraindications for Tekturna?
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What is important patient information to know when taking Tekturna?
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Study Notes
Tekturna (Aliskiren) Overview
- Tekturna, also known as Aliskiren, is primarily used for managing high blood pressure.
- Comes in oral tablet form, making it accessible for patients.
Mechanism of Action
- Functions as a Direct Renin Inhibitor, impacting the renin-angiotensin-aldosterone system to lower blood pressure.
Pharmacokinetics
- Aliskiren is metabolized in the liver with excretion occurring via fecal and biliary routes.
Monitoring Parameters
- Regular monitoring of renal function and potassium levels is essential to ensure patient safety during treatment.
Drug Interactions
- Important to be cautious with other medications:
- ACE inhibitors (ACEIs)
- Angiotensin receptor blockers (ARBs)
- P-glycoprotein substrates
- Cyclosporine might influence effectiveness or increase side effects.
Adverse Reactions
- Common side effects include:
- Diarrhea and abdominal pain/dyspepsia, particularly dose-related.
- Other potential reactions: cough, angioedema, and rash.
Contraindications
- Contraindicated for use with ACEIs and ARBs.
- Classified as pregnancy category D, implying potential risks in pregnancy.
Important Patient Information
- Patients may experience lightheadedness upon initiation of treatment.
- Avoid potassium supplements while on this medication to prevent hyperkalemia.
- Should not be taken with high-fat meals as it may affect absorption.
- Staying hydrated by drinking water is recommended during treatment.
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Description
This quiz provides an overview of Tekturna (Aliskiren), focusing on its mechanism of action as a Direct Renin Inhibitor and its usage in managing high blood pressure. Additionally, it covers pharmacokinetics, potential drug interactions, and important monitoring parameters to consider for patient safety.
