Agents of Abuse: Cocaine and Marijuana

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Questions and Answers

What is the primary consequence of long-term drug abuse?

Development of psychologic dependence
Development of both psychologic and physical dependence (correct)
Development of tolerance
Social and job-related problems

What is the primary function of neurotransmitters in the context of drug abuse?

To modify the user's mental state
To inhibit the release of corresponding neurotransmitters
To enhance the release of corresponding neurotransmitters
To facilitate communication between cells (correct)

Which of the following is NOT a type of neurotransmitter mentioned in the text?

Dopamine
GABA
COCAINE (correct)
Glutamate

What is the primary mechanism of action of cocaine?

It inhibits the CNS transporters of dopamine, norepinephrine, and serotonin (C) Signup and view all the answers

What is the term used to describe a drug abuser's overwhelming preoccupation with the procurement and use of a drug?

Drug addiction (A) Signup and view all the answers

Which of the following drugs is classified as a CNS stimulant?

Cocaine (C) Signup and view all the answers

What is the primary effect of Delta-9-tetrahydrocannabinol on adenylyl cyclase?

Inhibition through G-protein–linked cannabinoid receptors (A) Signup and view all the answers

Which of the following is a characteristic of cocaine use during a 'spree' or 'run'?

Intense euphoria (B) Signup and view all the answers

What is the primary function of Cannabidiol in the CNS?

No reported psychoactive effects (B) Signup and view all the answers

What is the main route of administration for marijuana that produces immediate effects?

Smoking (A) Signup and view all the answers

What is the effect of Cannabinol on the CNS?

Accounting for most CNS effects (C) Signup and view all the answers

What is the effect of cocaine on appetite?

Decrease (D) Signup and view all the answers

What is the effect of cocaine on the dopamine transporter in the CNS?

It inhibits the uptake of dopamine into nerve terminals (D) Signup and view all the answers

What is the common form of cocaine that can be smoked?

Crack (D) Signup and view all the answers

What is the result of cocaine's blockade of norepinephrine reuptake?

Cardiac toxicity and hypertensive episodes (B) Signup and view all the answers

What is the common psychological effect of cocaine withdrawal?

Severe depression of mood (B) Signup and view all the answers

What is the mechanism by which cocaine leads to an elevation of mood?

Blockade of dopamine reuptake (C) Signup and view all the answers

What is the result of cocaine's local anesthetic action?

Seizures (A) Signup and view all the answers

What is a characteristic physiologic effect of marijuana?

Reddening of the conjunctiva (C) Signup and view all the answers

What is a potential long-term effect of marijuana similar to those of cigarette smoking?

Periodontal disease (B) Signup and view all the answers

What is a therapeutic use of marijuana?

Treatment of glaucoma (D) Signup and view all the answers

What is a potential psychological effect of marijuana at extremely high doses?

Depersonalization (B) Signup and view all the answers

What is a potential effect of marijuana on the immune system?

Suppression of the immune system (C) Signup and view all the answers

What is a potential effect of marijuana on the reproductive system?

Decreased fertility (D) Signup and view all the answers

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