Pathology of Ageing - Hard

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Which term refers to 'the decline of fitness components of an individual with increasing age, owing to internal deterioration'?

Geriatrics

According to the ancient Greek theory, what was the consequence of the gradual consumption of 'innate heat and inevitable loss of body moisture'?

Increased dryness and coldness of the body

What is the primary focus of biogerontology?

The study of the biology of ageing and longevity

What does the term 'gerontology' primarily refer to?

<p>The process of becoming older</p> Signup and view all the answers

What is the main reason for the decrease in telomerase levels over time?

<p>Accumulated damage to cells and organs</p> Signup and view all the answers

Which phenomenon is characterized by the cessation of cell division?

<p>Cellular senescence</p> Signup and view all the answers

What is the function of telomeres in human chromosomes?

<p>Protect and separate chromosomes from others in DNA sequence</p> Signup and view all the answers

Why would enhancing telomerase levels be viewed as a positive statement in diseases like Parkinson’s disease but not in cancer?

<p>Enhanced telomerase levels may aid in tissue repair and function, beneficial for Parkinson's disease, but can promote tumor growth in cancer</p> Signup and view all the answers

What is the main benefit of hormone replacement therapy (HRT) according to the graph?

<p>Reduced risk of hip fractures</p> Signup and view all the answers

What is the most widely used and effective treatment for menopause?

<p>Hormone therapy (HRT)</p> Signup and view all the answers

What is the natural biological process marking the end of the menstrual cycle in females?

<p>Menopause</p> Signup and view all the answers

What is the main reason for the gradual decrease in estrogen and progesterone production leading up to menopause?

<p>Perimenopause</p> Signup and view all the answers

What physiological changes occur in the brain with age, according to the provided data?

<p>Decrease in brain weight</p> Signup and view all the answers

What is the impact of an active lifestyle on muscle mass and flexibility with age?

<p>Less muscle mass loss and greater flexibility</p> Signup and view all the answers

How is homeostatic response altered in aging?

<p>Maintained at a level of decreased function</p> Signup and view all the answers

What is the main reason for the occurrence of perimenopause?

<p>Gradual decrease in estrogen and progesterone production</p> Signup and view all the answers

What is the main contributor to disability in older people?

<p>Involuntary loss of muscle mass, strength, and function (sarcopenia)</p> Signup and view all the answers

What is the primary treatment for sarcopenia?

<p>Exercise-based approaches, particularly resistance or strength training</p> Signup and view all the answers

Which tissue type experiences muscular atrophy in injury and ageing?

<p>Muscle tissue</p> Signup and view all the answers

What is a major impact of the ageing process on the skin?

<p>Increased risk of skin neoplasms</p> Signup and view all the answers

What are the age-related changes in the eye primarily attributed to?

<p>Lens growth</p> Signup and view all the answers

What is a common effect of ageing on hearing?

<p>Hearing loss</p> Signup and view all the answers

What aspect of the human body does the ageing process impact?

<p>Various aspects including cellular senescence and changes in connective, muscle, epithelial, and neuronal/neural tissue</p> Signup and view all the answers

What is a prevalent issue in older people related to the gastrointestinal (GI) system?

<p>Gastrointestinal symptoms affecting absorption and metabolism of foods, vitamins, and medications</p> Signup and view all the answers

What becomes more prevalent with increasing age?

<p>Gastro‐Oesophageal Reflux Disease (GORD/GERD)</p> Signup and view all the answers

What has been discovered to play a major role in causing many peptic ulcers?

<p>Helicobacter pylori</p> Signup and view all the answers

What is the most effective treatment for Gastro‐Oesophageal Reflux Disease (GORD/GERD)?

<p>Proton-pump inhibitors</p> Signup and view all the answers

What is the primary impact of the ageing process on skeletal muscle?

<p>Muscular atrophy</p> Signup and view all the answers

Which tissue type experiences decreased collagen solubility and increased rigidity in the ageing process?

<p>Connective</p> Signup and view all the answers

What is the largest part of the brain responsible for information processing and folded into sulci and gyri?

<p>Cerebral cortex</p> Signup and view all the answers

Which part of the brain is divided into four lobes: frontal, parietal, occipital, and temporal?

<p>Cerebral cortex</p> Signup and view all the answers

What is the basic signaling unit of the nervous system with specialized connections called synapses for chemical communication?

<p>Neurons</p> Signup and view all the answers

What may lead to decreased intestinal barrier function, impacting the absorption of certain nutrients and causing systemic inflammation in the ageing process?

<p>The ageing process</p> Signup and view all the answers

What type of tissue plays a fundamental role in establishing tissue barriers and undergoes changes in ageing, impacting organ function?

<p>Epithelial</p> Signup and view all the answers

What type of tissue connects, supports, and separates other tissues and organs, and undergoes changes in ageing, including decreased collagen solubility and increased rigidity?

<p>Connective</p> Signup and view all the answers

What experiences changes in molecules, cells, vasculature, and gross morphology in the ageing process, leading to atrophic changes, volume decline, and the development of white matter lesions?

<p>The brain</p> Signup and view all the answers

What is not a direct consequence of ageing, but ageing makes the neuronal tissue more susceptible to these diseases?

<p>Age-related diseases of the brain</p> Signup and view all the answers

What shows compensatory changes in dendritic arbour, spines, and synapses to help re-establish synaptic connections lost from cell death in the ageing process?

<p>The ageing brain</p> Signup and view all the answers

What leads to tissue stiffening, particularly in collagen tissues, in the ageing process?

<p>Advanced glycation end-products (AGEs)</p> Signup and view all the answers

What is divided into the forebrain, midbrain, and hindbrain, with the cerebral cortex being the largest part responsible for information processing and folded into sulci and gyri?

<p>The brain</p> Signup and view all the answers

Which tissue type plays a fundamental role in establishing tissue barriers and undergoes changes in ageing?

<p>Epithelial tissue</p> Signup and view all the answers

What is the largest part of the brain responsible for information processing and folded into sulci and gyri?

<p>Cerebral cortex</p> Signup and view all the answers

Which part of the brain is divided into four lobes: frontal, parietal, occipital, and temporal, each with specific functions?

<p>Cerebral cortex</p> Signup and view all the answers

What are the basic signaling units of the nervous system and have specialized connections called synapses for chemical communication?

<p>Neurons</p> Signup and view all the answers

What may become more harmful to the ageing brain due to the changes in the ageing process?

<p>Proteins associated with neurodegenerative diseases</p> Signup and view all the answers

What experiences changes in molecules, cells, vasculature, and gross morphology, leading to atrophic changes, volume decline, and the development of white matter lesions in the ageing process?

<p>Brain</p> Signup and view all the answers

What shows compensatory changes in dendritic arbour, spines, and synapses to help re-establish synaptic connections lost from cell death in the ageing process?

<p>Brain</p> Signup and view all the answers

What leads to tissue stiffening, particularly in collagen tissues, in the ageing process?

<p>Decreased collagen solubility</p> Signup and view all the answers

What type of tissue connects, supports, and separates other tissues and organs, and undergoes changes in ageing?

<p>Connective tissue</p> Signup and view all the answers

Which age-related diseases of the brain are not a direct consequence of ageing but make the neuronal tissue more susceptible to these diseases?

<p>Alzheimer's and Parkinson's</p> Signup and view all the answers

What tissue type plays a role in decreasing intestinal barrier function, impacting the absorption of certain nutrients and causing systemic inflammation in the ageing process?

<p>Epithelial tissue</p> Signup and view all the answers

What undergoes changes in ageing, including decreased collagen solubility and increased rigidity?

<p>Connective tissue</p> Signup and view all the answers

Study Notes

Cellular Organisation and Ageing: Tissue Types and Brain Structure

  • There are four main types of tissue: connective, epithelial, neural/neuronal, and muscle, all of which undergo changes in the ageing process.
  • Connective tissue connects, supports, and separates other tissues and organs, and it undergoes changes in ageing, including decreased collagen solubility and increased rigidity.
  • Advanced glycation end-products (AGEs) formed in ageing lead to tissue stiffening, particularly in collagen tissues.
  • Epithelial tissue plays a fundamental role in establishing tissue barriers and undergoes changes in ageing, impacting organ function.
  • The brain is comprised of the forebrain, midbrain, and hindbrain, with the cerebral cortex being the largest part responsible for information processing and folded into sulci and gyri.
  • The cerebral cortex is divided into four lobes: frontal, parietal, occipital, and temporal, each with specific functions.
  • Neurons are the basic signaling units of the nervous system and have specialized connections called synapses for chemical communication.
  • The ageing brain experiences changes in molecules, cells, vasculature, and gross morphology, leading to atrophic changes, volume decline, and the development of white matter lesions.
  • Age-related diseases of the brain, such as Alzheimer's and Parkinson's, are not a direct consequence of ageing, but ageing makes the neuronal tissue more susceptible to these diseases.
  • Proteins associated with neurodegenerative diseases may become more harmful to the ageing brain due to the changes in the ageing process.
  • The ageing process may lead to decreased intestinal barrier function, impacting the absorption of certain nutrients and causing systemic inflammation.
  • The ageing brain shows compensatory changes in dendritic arbour, spines, and synapses to help re-establish synaptic connections lost from cell death.

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