Podcast
Questions and Answers
Which factor may lead to decreased absorption of some medications in older persons?
Which factor may lead to decreased absorption of some medications in older persons?
How does reduced serum albumin impact drug effects in older persons?
How does reduced serum albumin impact drug effects in older persons?
Which condition can decrease calcium absorption and increase the risk of constipation in older persons?
Which condition can decrease calcium absorption and increase the risk of constipation in older persons?
What impact do altered or variable pharmacokinetics and pharmacodynamics have on medication management for older persons?
What impact do altered or variable pharmacokinetics and pharmacodynamics have on medication management for older persons?
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What may lead to increased serum concentrations of unbound drugs in older persons?
What may lead to increased serum concentrations of unbound drugs in older persons?
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Study Notes
Medication Absorption in Older Adults
- Decreased gastrointestinal motility and altered gastric pH can lead to reduced absorption of certain medications in older individuals.
Serum Albumin and Drug Effects
- Lower serum albumin levels in older persons can result in increased free (unbound) concentrations of drugs, intensifying their therapeutic and side effects.
Calcium Absorption and Constipation
- Conditions such as decreased vitamin D synthesis or gastrointestinal disorders can impair calcium absorption, raising the risk of constipation in older adults.
Pharmacokinetics and Pharmacodynamics in Older Adults
- Altered pharmacokinetics (how the body processes drugs) and pharmacodynamics (how drugs affect the body) can complicate medication management, leading to a higher risk of adverse drug reactions and necessitating careful monitoring and dosage adjustments.
Serum Concentrations of Unbound Drugs
- Factors such as decreased protein binding due to lower albumin levels or alterations in body composition can increase serum concentrations of unbound drugs, impacting efficacy and safety in older patients.
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Description
This quiz provides an introduction to the complexities of medication management for older persons in the context of a rapidly ageing global population. It covers age-related physiological, functional, cognitive, and social changes and their impact on medication use, with a focus on the role of pharmacists.
