3-L2+

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Questions and Answers

Which of the following is the final common central pathway for the oxidation of fuel molecules?

  • Electron transport chain
  • Oxidative phosphorylation
  • Glycolysis
  • Citric acid cycle (correct)

Which of the following is the most important regulated enzyme in the Citric acid cycle?

  • Citrate synthase
  • Alpha-ketoglutarate dehydrogenase complex (correct)
  • Isocitrate dehydrogenase
  • Succinate dehydrogenase

During fasting or starvation, what is the primary source of glucose for the body after liver glycogen is depleted?

  • Protein catabolism
  • Ketogenesis
  • Gluconeogenesis (correct)
  • Fatty acid oxidation

Which organ is the major site of gluconeogenesis?

<p>Liver (A)</p> Signup and view all the answers

What is the primary drive for the regulation of the Citric acid cycle?

<p>Both NADH/NAD+ and ATP/ADP ratios (B)</p> Signup and view all the answers

Which of the following tissues are primarily dependent on glucose during fasting or starvation?

<p>Central nervous system (D)</p> Signup and view all the answers

Which process occurs as part of the response to stress situations such as fasting and is largely under hormonal control?

<p>Gluconeogenesis (D)</p> Signup and view all the answers

What happens to the activity of PEPCK in response to insulin?

<p>Decreases (B)</p> Signup and view all the answers

Which hormone stimulates gluconeogenesis by lowering the level of fructose 2,6-bisphosphate?

<p>Glucagon (A)</p> Signup and view all the answers

What is the main reason for increased rates of gluconeogenesis leading to hyperglycaemia in diabetes?

<p>Inadequate biologically effective insulin levels (A)</p> Signup and view all the answers

Which compound inhibits Fructose 1,6-bisphosphatase, favoring gluconeogenesis over glycolysis?

<p>AMP (C)</p> Signup and view all the answers

What is the process that enables galactose to be synthesized from glucose via UDP-glucose?

<p>Epimerase reaction (A)</p> Signup and view all the answers

'Galactosaemia' is characterized by the absence of which enzyme leading to the accumulation of galactose in tissues?

<p>'Transferase enzyme' (D)</p> Signup and view all the answers

'Galactosaemia' can lead to cataract formation due to which reaction depleting tissues of NADPH?

<p>'Aldose reductase' activity (A)</p> Signup and view all the answers

'Galactosaemia' may contribute to glaucoma due to the accumulation of what in the eye?

<p>'Galactitol' (C)</p> Signup and view all the answers

'Duarte type' of 'Galactosaemia' is characterized by the rare absence of which enzyme leading to the accumulation of galactose in tissues?

<p>'Kinase enzyme' (B)</p> Signup and view all the answers

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