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Questions and Answers
What type of immunosuppressant drug is cyclosporine?
Which of the following is an example of an anti-proliferative agent?
What is the function of cytokine gene expression inhibitors?
Which type of immunosuppressant drug includes sirolimus?
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What type of immunosuppressant drug is basiliximab?
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Which of the following is NOT a type of immunosuppressant drug?
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What is the function of calcineurin inhibitors?
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Which of the following is an example of a monoclonal antibody-based agent?
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What type of immunosuppressant drug includes mycophenolate mofetil?
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Which of the following is a function of immunosuppressant drugs?
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Study Notes
Adverse Effects of Metronidazole
- Unpleasant, metallic taste is commonly experienced
- Oral moniliasis (Candidiasis) is a possible side effect
- Rarely, neurotoxicity (dizziness, vertigo, and numbness or paresthesia) may occur, which may necessitate discontinuation of the drug
- Pregnancy category: B
- Alcohol intolerance (Disulfiram-like reaction) may occur
Co-administration and Contraindications
- Co-administration with mebendazole is contraindicated due to the risk of Steven Johnson syndrome (Epidermal necrolysis)
Comparison with Tinidazole
- Tinidazole has a longer duration of action and fewer adverse effects
- Tinidazole is category C in pregnancy
- Metronidazole has a higher efficacy regarding antibacterial effect
Diloxanide Furate
- Works only in the lumen of the gastrointestinal tract (GIT) as a lumenal amebicide
Viral Replication and Antiviral Drugs
- Viral replication involves several steps:
- Viral fusion and entry
- Uncoating of viral nucleic acid
- Synthesis and replication of genetic material (regulated by polymerase enzyme)
- Viral assembly (maturation) (regulated by protease enzyme)
- Viral release (regulated by neuroaminidase enzyme)
- Antiviral drugs can target any of these steps
Adjuvant Therapy
- Can be used in combination with surgery and/or radiation
Classification of Immune-therapies
- Immunosuppressant drugs:
- Calcineurin inhibitors (e.g., cyclosporine, tacrolimus)
- Mammalian Target of Rapamycin inhibitors (e.g., Sirolimus)
- Anti-proliferative agents (e.g., azathioprine, mycophenolate mofetil)
- Cytokine gene expression inhibitors (e.g., Corticosteroids)
- Monoclonal anti-body based agents (e.g., basiliximab, muromonab)
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Description
This quiz covers the unpleasant side effects of a certain medication, including metallic taste, oral yeast infection, and neurotoxicity symptoms.
