Adverse Effects of Ion Channel Blockers: Amantadine and Rimantadine
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Questions and Answers

Which of the following drugs causes fewer CNS reactions compared to Amantadine?

  • Baloxavir
  • Rimantadine (correct)
  • Peramivir
  • Tamiflu
  • What type of adverse effects is Amantadine mainly associated with?

  • Central Nervous System (correct)
  • Cardiovascular
  • Gastrointestinal
  • Renal
  • What feature distinguishes how Peramivir and Baloxavir are administered?

  • Oral administration
  • Subcutaneous injection
  • Intravenous administration (correct)
  • Intramuscular injection
  • How long is Baloxavir typically administered for in the treatment of influenza?

    <p>One-day treatment</p> Signup and view all the answers

    What is a known consequence of resistance to M2 ion channel blockers?

    <p>Change in amino acid of the M2 matrix protein</p> Signup and view all the answers

    Which anti-influenza medication is more suitable for pregnant women based on safety studies?

    <p>Oral Tamiflu (oseltamivir)</p> Signup and view all the answers

    What was the criteria for selecting the adult participants in the Oseltamivir Phase III Studies?

    <p>18-65 years old with febrile respiratory and systemic symptoms</p> Signup and view all the answers

    What was not considered a systemic symptom in the Oseltamivir Phase III Studies?

    <p>Runny nose</p> Signup and view all the answers

    In the Oseltamivir Treatment study in the rest of the world (ROW), what was the duration of illness for patients receiving Oseltamivir compared to placebo?

    <p>Lower for patients receiving Oseltamivir</p> Signup and view all the answers

    What was the significance level (p-value) for the duration of illness difference between patients receiving Oseltamivir and placebo in the rest of the world (ROW) study?

    <p>$0.02$</p> Signup and view all the answers

    Based on the provided text, which M2 ion channel blocker was NOT mentioned in the studies?

    <p>Baloxavir</p> Signup and view all the answers

    What is the preferred treatment for pregnant individuals according to the text?

    <p>Oseltamivir as a five-day treatment</p> Signup and view all the answers

    Which adverse effects are commonly associated with oseltamivir?

    <p>Gastrointestinal discomfort and nausea</p> Signup and view all the answers

    Which medication's therapeutic spectrum is limited to influenza A infections according to the text?

    <p>Amantadine</p> Signup and view all the answers

    What is the mechanism of action of M2 ion channel blockers like Amantadine and Rimantadine?

    <p>Preventing viral release within infected cells</p> Signup and view all the answers

    In the United States, why are adamantanes like Amantadine and Rimantadine not recommended for the treatment or prophylaxis of influenza A?

    <p>Widespread resistance in circulating influenza A strains</p> Signup and view all the answers

    Which of the following is not a common adverse effect of oseltamivir according to the text?

    <p>Skin rash</p> Signup and view all the answers

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