17 Questions
Which of the following drugs causes fewer CNS reactions compared to Amantadine?
Rimantadine
What type of adverse effects is Amantadine mainly associated with?
Central Nervous System
What feature distinguishes how Peramivir and Baloxavir are administered?
Intravenous administration
How long is Baloxavir typically administered for in the treatment of influenza?
One-day treatment
What is a known consequence of resistance to M2 ion channel blockers?
Change in amino acid of the M2 matrix protein
Which anti-influenza medication is more suitable for pregnant women based on safety studies?
Oral Tamiflu (oseltamivir)
What was the criteria for selecting the adult participants in the Oseltamivir Phase III Studies?
18-65 years old with febrile respiratory and systemic symptoms
What was not considered a systemic symptom in the Oseltamivir Phase III Studies?
Runny nose
In the Oseltamivir Treatment study in the rest of the world (ROW), what was the duration of illness for patients receiving Oseltamivir compared to placebo?
Lower for patients receiving Oseltamivir
What was the significance level (p-value) for the duration of illness difference between patients receiving Oseltamivir and placebo in the rest of the world (ROW) study?
$0.02$
Based on the provided text, which M2 ion channel blocker was NOT mentioned in the studies?
Baloxavir
What is the preferred treatment for pregnant individuals according to the text?
Oseltamivir as a five-day treatment
Which adverse effects are commonly associated with oseltamivir?
Gastrointestinal discomfort and nausea
Which medication's therapeutic spectrum is limited to influenza A infections according to the text?
Amantadine
What is the mechanism of action of M2 ion channel blockers like Amantadine and Rimantadine?
Preventing viral release within infected cells
In the United States, why are adamantanes like Amantadine and Rimantadine not recommended for the treatment or prophylaxis of influenza A?
Widespread resistance in circulating influenza A strains
Which of the following is not a common adverse effect of oseltamivir according to the text?
Skin rash
This quiz covers the adverse effects associated with Amantadine and Rimantadine, particularly CNS reactions like insomnia, dizziness, hallucinations, and seizures. It also discusses the need for caution in patients with psychiatric issues, renal impairment, and during pregnancy or nursing. Test your knowledge on the side effects of these ion channel blockers.
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