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Questions and Answers
What is the primary cause of toxicity mentioned in the text?
Which of the following is an example of toxicity due to the extension of therapeutic effect given in the text?
What type of adverse effect is mentioned in the text related to digoxin?
Which medication is associated with the risk of bleeding?
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Which of the following statements is NOT supported by the information provided in the text?
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Study Notes
Adverse Drug Events vs. Adverse Drug Reactions
- Adverse drug events (ADEs) occur during drug therapy without a direct causal relationship to the medication.
- Adverse drug reactions (ADRs) are directly related to the medication and occur during appropriate use.
Examples of Adverse Drug Reactions
- Expected extensions of therapeutic effects can manifest as adverse reactions; for instance, heparin may lead to bleeding.
- Subsequent exposure to a drug can trigger an antigen-antibody interaction, leading to allergic symptoms.
Specific Drug Effects
- Quinine and quinidine can cause a range of side effects, including:
- Cramps
- Diarrhea
- Purpura (purple spots on the skin)
- Asthma attacks
- Vascular collapse in some individuals
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Description
Learn the difference between an adverse drug event, which occurs during drug therapy without a necessary causal relationship with the drug, and an adverse drug reaction, which is directly related to the drug and occurs during its appropriate use.
