5 Questions
What are the key structures and biological factors involved in drug absorption, distribution, metabolism, and excretion (ADME)?
Key structures and biological factors involved in ADME include the site of administration for absorption, metabolic enzymes, plasma protein binding for distribution, organ systems for metabolism and excretion (e.g., liver and kidneys).
What are CP, Cmax, and Tmax in pharmacokinetics, and how can they be calculated?
CP refers to plasma concentration, Cmax refers to peak plasma concentration, and Tmax refers to the time to reach peak plasma concentration. They can be calculated using pharmacokinetic equations and data from drug concentration-time profiles.
What dictates and limits drug absorption?
Drug absorption is dictated and limited by factors such as the physicochemical properties of the drug (e.g., solubility, lipophilicity), the route of administration, and physiological factors at the absorption site (e.g., pH, blood flow).
What is the drug life cycle in the context of pharmacokinetics and pharmacodynamics?
The drug life cycle involves application, pharmacokinetics (absorption, metabolism, accumulation, distribution, excretion), pharmacodynamics (clinical effect, place of effect, pharmacological effect, toxic effect), and drug application (e.g., how it gets into the body, drug formation/stability considerations, patient safety).
What is meant by drug absorption in pharmacokinetics?
Drug absorption refers to the passage of a drug from its site of administration into the circulation, which is essential for the drug to reach its target site of action and exert its therapeutic effects.
Test your knowledge of advanced pharmacokinetics with this quiz covering absorption, distribution, metabolism, and excretion (ADME). Recognize, define, and use key pharmacological terms in the appropriate contexts and outline the key structures and biological factors involved in drug ADME. Sharpen your understanding of pharmacology with this quiz.
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