Questions and Answers
What is the generic name for Advair?
Fluticasone Propionate with Salmeterol Xinafoate
What is the drug class of Advair?
Antiasthmatic
What are the dosage forms available for Advair in Diskus?
100/50, 250/50, 500/50
What are the dosage forms available for Advair in HFA?
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What is the recommended dosage for long-term maintenance of asthma with Advair?
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What kind of drug is fluticasone propionate?
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Corticosteroids bind to ______ to form ______.
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What does the steroid-receptor complex react with?
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What does the stimulation of m-RNA result in?
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What does salmeterol stimulate?
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What is the association of increased c-AMP?
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What is the onset and duration of action for Advair?
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What may decrease the effectiveness of Advair?
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What are some contraindications for using Advair?
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What are some common adverse effects of Advair?
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What should patients do if they miss a dose of Advair?
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Study Notes
Advair Overview
- Generic name: Fluticasone Propionate with Salmeterol Xinafoate
- Class: Antiasthmatic
Dosage Forms
- Diskus:
- Available in strengths: 100/50, 250/50, 500/50
- Each dose contains 50 mcg salmeterol (as 72.5 mcg salmeterol xinafoate) with either 100, 250, or 500 mcg fluticasone propionate
- HFA:
- Available in strengths: 45/21, 115/21, 230/21
- Each dose contains 21 mcg salmeterol (as 30.45 mcg salmeterol xinafoate) with either 45, 115, or 230 mcg fluticasone propionate
Indications and Dosages
- Long-term asthma maintenance: 1 Diskus inhalation or 2 HFA inhalations twice daily (12 hours apart)
- COPD treatment: 1 inhalation of Advair 250/50 twice daily (morning and evening)
Recommended Dosage
- Consistent administration: 1 Diskus inhalation or 2 HFA inhalations twice daily, spaced 12 hours apart
Mechanism of Action
- Fluticasone propionate: Synthetic, trifluorinated corticosteroid
- Corticosteroids bind to specific receptor proteins in the cytoplasm, forming a steroid-receptor complex
- This complex interacts with chromatin or DNA, influencing m-RNA transcription
- Stimulation of m-RNA leads to the synthesis of proteins and enzymes with anti-inflammatory effects
Salmeterol Action
- Stimulates adenyl cyclase, increasing c-AMP from ATP
- Increased c-AMP results in:
- Relaxation of bronchial, uterine, and vascular smooth muscle via beta-2-adrenergic receptors
- Inhibition of mediators of immediate hypersensitivity from mast cells
Pharmacokinetics
- Onset: Within 20 minutes
- Duration: Approximately 12 hours
Drug Interactions
- Beta-blockers may reduce Advair's effectiveness
- Other sympathomimetics, tricyclic antidepressants, and monoamine oxidase inhibitors can heighten toxicity
Contraindications and Precautions
- Not for primary treatment of status asthmaticus
- Avoid use with long-acting beta-2-adrenergic agonists
- Use cautiously in patients transitioning from systemic corticosteroids (may require systemic steroids during stress events)
- Not for rapid relief of bronchospasm
- Risk of fungal infections in the mouth
- Caution in patients with cardiovascular disease, hypertension, hyperthyroidism, diabetes mellitus, and nursing mothers
- Pregnancy category C
Adverse Effects
- Common effects include upper respiratory tract infections, pharyngitis, headache, nausea, vomiting, sinusitis, bronchitis, cough, rash, and angioedema
Patient Consultation
- Avoid eye contact and rinse mouth post-use
- Report prolonged side effects to a physician
- Missed doses: skip and resume normal schedule
- Not for immediate relief; use regularly for optimal benefits
- Ensure proper usage technique is understood
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Description
Test your knowledge about Advair, a combination medication used to treat asthma. This quiz covers its generic name, drug class, and dosage forms. Ideal for students and healthcare professionals alike.
