Podcast
Questions and Answers
Which enzyme metabolizes catecholamines in the synaptic space?
Which enzyme metabolizes catecholamines in the synaptic space?
- Both COMT and MAO
- Catechol-O-methyltransferase (COMT) (correct)
- Neither COMT nor MAO
- Monoamine oxidase (MAO)
Which type of receptors do catecholamines potently activate?
Which type of receptors do catecholamines potently activate?
- Neither α nor β receptors
- α receptors
- Both α and β receptors (correct)
- β receptors
Which of the following is NOT a catecholamine?
Which of the following is NOT a catecholamine?
- Epinephrine
- Norepinephrine
- Isoproterenol
- Phenylephrine (correct)
Which type of drugs are sympathomimetic amines that contain the 3,4-dihydroxybenzene group?
Which type of drugs are sympathomimetic amines that contain the 3,4-dihydroxybenzene group?
Which receptors have a higher potency for isoproterenol compared to epinephrine and norepinephrine?
Which receptors have a higher potency for isoproterenol compared to epinephrine and norepinephrine?
Flashcards
Catechol-O-methyltransferase (COMT)
Catechol-O-methyltransferase (COMT)
An enzyme responsible for breaking down catecholamines in the synaptic space.
Alpha and Beta Receptors
Alpha and Beta Receptors
Catecholamines primarily bind to and activate these receptors.
Phenylephrine
Phenylephrine
This drug does not belong to the catecholamine family.
Catecholamines
Catecholamines
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Isoproterenol
Isoproterenol
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Study Notes
Enzyme and Metabolism
- Catechol-O-methyltransferase (COMT) metabolizes catecholamines in the synaptic space, playing a critical role in neurotransmitter regulation.
Receptors Activated by Catecholamines
- Catecholamines, such as dopamine, norepinephrine, and epinephrine, potently activate adrenergic receptors, which are divided into alpha (α) and beta (β) types.
Identification of Catecholamines
- Catecholamines include dopamine, norepinephrine, and epinephrine; they are derived from tyrosine. A substance that does not fit this category, such as serotonin, is NOT classified as a catecholamine.
Sympathomimetic Amines
- Sympathomimetic amines containing the 3,4-dihydroxybenzene group are classified as catecholamines. This structural feature is crucial for their activity as neurotransmitters.
Receptor Potency Comparison
- Beta-adrenergic receptors, particularly β1 and β2 receptors, have higher potency for isoproterenol compared to epinephrine and norepinephrine, making isoproterenol a more effective agonist for these receptors.
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