Adrenergic Agonists Quiz
24 Questions
2 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the reason noncatecholamines have a longer half-life compared to catecholamines?

  • They have the ability to selectively activate certain receptors to the exclusion of others.
  • They are more polar than catecholamines, allowing them to cross the blood brain barrier more easily.
  • They lack a catechol group, making them substrates for COMT and metabolize slowly by MAO. (correct)
  • They undergo rapid degradation by MAO and COMT, resulting in a longer half-life.

    • At low doses, what is the receptor specificity of albuterol?

  • Acts on A1 and B2 receptors
  • Acts on B2 receptors only (correct)
  • Acts on B1 and B2 receptors
  • Acts on A1 receptors only

    • What effect does activation of alpha-1 receptors produce?

  • Vasoconstriction in blood vessels of the skin, viscera, and mucous membranes (correct)
  • Mydriasis
  • Reduction of sympathetic outflow to the heart and blood vessels
  • Vasodilation in blood vessels of the skin, viscera, and mucous membranes

    • What is the primary therapeutic application of drugs acting on beta-1 receptors?

    <p>Treatment of shock</p> Signup and view all the answers

    What adverse effect can be caused by overstimulation of B1 receptors?

    <p>Tachycardia and dysrhythmias</p> Signup and view all the answers

    What is the therapeutic application of drugs acting on B2 receptors?

    <p>Treatment of asthma</p> Signup and view all the answers

    Why are most asthma medications inhaled medications?

    <p>To reduce adverse effects</p> Signup and view all the answers

    What is the primary therapeutic effect of dopamine receptor activation?

    <p>Improving renal perfusion</p> Signup and view all the answers

    What effect does activation of alpha-2 receptors in the central nervous system have?

    <p>Reduction of sympathetic outflow to the heart and blood vessels</p> Signup and view all the answers

    What is the adverse effect associated with activation of B2 receptors?

    <p>Tremor</p> Signup and view all the answers

    How do noncatecholamines differ from catecholamines in terms of oral administration?

    <p>Noncatecholamines can be given orally as they do not undergo rapid degradation by MAO and COMT like catecholamines.</p> Signup and view all the answers

    What causes the pink or brown pigmentation in catecholamine-containing solutions over time?

    <p>Oxidation of the catecholamine molecule</p> Signup and view all the answers

    What is the primary mechanism of action for adrenergic agonists?

    <p>Direct or indirect activation of adrenergic receptors</p> Signup and view all the answers

    Which class of adrenergic agonists includes dopamine, epinephrine, and isoproterenol?

    <p>Catecholamines</p> Signup and view all the answers

    What is the defining feature of catecholamines?

    <p>They contain a benzene ring with hydroxyl groups and an amine group</p> Signup and view all the answers

    What is the primary reason why catecholamines cannot be used orally?

    <p>They are quickly metabolized by enzymes in the gastrointestinal tract</p> Signup and view all the answers

    What is the role of COMT in the metabolism of catecholamines?

    <p>It catalyzes the breakdown of catecholamines in the brain</p> Signup and view all the answers

    Which property do all catecholamines have in common?

    <p>Quick metabolism by MAO and COMT enzymes</p> Signup and view all the answers

    What distinguishes noncatacholamines from catecholamines?

    <p>They can be used orally</p> Signup and view all the answers

    What is the main difference between direct and indirect adrenergic receptor activation?

    <p>Direct activation works on receptor binding, while indirect activation involves promotion of norepinephrine release</p> Signup and view all the answers

    Why are noncatecholamines able to act in the central nervous system?

    <p>They are not affected by the blood-brain barrier</p> Signup and view all the answers

    What is the distinguishing feature between dopamine and dobutamine among major catecholamines?

    <p>Dopamine contains a benzene ring with hydroxyl groups and an amine group, while dobutamine does not</p> Signup and view all the answers

    Which enzyme is involved in the breakdown of catecholamines primarily within the liver?

    <p>Monoamine oxidase (MAO)</p> Signup and view all the answers

    What effect does adrenaline have on adrenergic receptors?

    <p>It activates beta-adrenergic receptors in smooth muscle</p> Signup and view all the answers

    More Like This

    Use Quizgecko on...
    Browser
    Open
    Browser
    Browser