Podcast
Questions and Answers
What is the reason noncatecholamines have a longer half-life compared to catecholamines?
What is the reason noncatecholamines have a longer half-life compared to catecholamines?
- They have the ability to selectively activate certain receptors to the exclusion of others.
- They are more polar than catecholamines, allowing them to cross the blood brain barrier more easily.
- They lack a catechol group, making them substrates for COMT and metabolize slowly by MAO. (correct)
- They undergo rapid degradation by MAO and COMT, resulting in a longer half-life.
At low doses, what is the receptor specificity of albuterol?
At low doses, what is the receptor specificity of albuterol?
- Acts on A1 and B2 receptors
- Acts on B2 receptors only (correct)
- Acts on B1 and B2 receptors
- Acts on A1 receptors only
What effect does activation of alpha-1 receptors produce?
What effect does activation of alpha-1 receptors produce?
- Vasoconstriction in blood vessels of the skin, viscera, and mucous membranes (correct)
- Mydriasis
- Reduction of sympathetic outflow to the heart and blood vessels
- Vasodilation in blood vessels of the skin, viscera, and mucous membranes
What is the primary therapeutic application of drugs acting on beta-1 receptors?
What is the primary therapeutic application of drugs acting on beta-1 receptors?
What adverse effect can be caused by overstimulation of B1 receptors?
What adverse effect can be caused by overstimulation of B1 receptors?
What is the therapeutic application of drugs acting on B2 receptors?
What is the therapeutic application of drugs acting on B2 receptors?
Why are most asthma medications inhaled medications?
Why are most asthma medications inhaled medications?
What is the primary therapeutic effect of dopamine receptor activation?
What is the primary therapeutic effect of dopamine receptor activation?
What effect does activation of alpha-2 receptors in the central nervous system have?
What effect does activation of alpha-2 receptors in the central nervous system have?
What is the adverse effect associated with activation of B2 receptors?
What is the adverse effect associated with activation of B2 receptors?
How do noncatecholamines differ from catecholamines in terms of oral administration?
How do noncatecholamines differ from catecholamines in terms of oral administration?
What causes the pink or brown pigmentation in catecholamine-containing solutions over time?
What causes the pink or brown pigmentation in catecholamine-containing solutions over time?
What is the primary mechanism of action for adrenergic agonists?
What is the primary mechanism of action for adrenergic agonists?
Which class of adrenergic agonists includes dopamine, epinephrine, and isoproterenol?
Which class of adrenergic agonists includes dopamine, epinephrine, and isoproterenol?
What is the defining feature of catecholamines?
What is the defining feature of catecholamines?
What is the primary reason why catecholamines cannot be used orally?
What is the primary reason why catecholamines cannot be used orally?
What is the role of COMT in the metabolism of catecholamines?
What is the role of COMT in the metabolism of catecholamines?
Which property do all catecholamines have in common?
Which property do all catecholamines have in common?
What distinguishes noncatacholamines from catecholamines?
What distinguishes noncatacholamines from catecholamines?
What is the main difference between direct and indirect adrenergic receptor activation?
What is the main difference between direct and indirect adrenergic receptor activation?
Why are noncatecholamines able to act in the central nervous system?
Why are noncatecholamines able to act in the central nervous system?
What is the distinguishing feature between dopamine and dobutamine among major catecholamines?
What is the distinguishing feature between dopamine and dobutamine among major catecholamines?
Which enzyme is involved in the breakdown of catecholamines primarily within the liver?
Which enzyme is involved in the breakdown of catecholamines primarily within the liver?
What effect does adrenaline have on adrenergic receptors?
What effect does adrenaline have on adrenergic receptors?
