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Questions and Answers
ADRENERGIC NEURONS & RECEPTORS (A) NOREPINEPHRINE (1) Synthesis Tyrosine enters the neuron through a Na channel cotransport Conversion from tyrosine to L-DOPA L-DOPA gets converted to Dopamine Dopamine gets converted to ______ inside intracellular vesicles Action potential activates voltage gated Ca++ channels
Norepinephrine
TYPES OF AGONISTS II) BETA-ADRENERGIC AGONISTS (A) BETA-1 AGONISTS (B) BETA-1+2 AGONIST (C) BETA-2 AGONIST (D) BETA-3 AGONIST III) ALPHA+BETA AGONIST (A) ______
NOREPINEPHRINE
GRAPHICAL REPRESENTATIONS OF CVS EFFECTS OF NOREPINEPHRINE, EPINEPHRINE, & ISOPROTERENOL (A) NOREPINEPHRINE (B) EPINEPHRINE (C) ISOPROTERENOL (D) SUMMARY V) APPENDIX VI) REVIEW QUESTIONS VII) REFERENCES I) ADRENERGIC NEURONS & RECEPTORS (A) NOREPINEPHRINE (1) Synthesis Tyrosine enters the neuron through a Na channel cotransport Conversion from tyrosine to L-DOPA L-DOPA gets converted to Dopamine Dopamine gets converted to Norepinephrine inside intracellular vesicles Action potential activates voltage gated Ca++ channels (2) Receptors (i) 1 receptor o Works through the Phosphol.
EPINEPHRINE + DOPAMINE
BETA-1+2 AGONIST (C) BETA-2 AGONIST (D) BETA-3 AGONIST III) ALPHA+BETA AGONIST (A) NOREPINEPHRINE (B) ______
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Receptors (i) 1 receptor o Works through the ______
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Which receptor works through the Phosphol?
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What is the final product of the synthesis of tyrosine inside adrenergic neurons?
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Which type of agonist acts on both Beta-1 and Beta-2 receptors?
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What is the neurotransmitter involved in the Alpha+Beta agonist category?
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Which agonist acts specifically on the Beta-3 receptor?
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Study Notes
Adrenergic Neurons & Receptors
- Norepinephrine is synthesized from tyrosine, which enters neurons via sodium channel cotransport.
- Tyrosine is converted to L-DOPA, then to dopamine, and finally dopamine is transformed into norepinephrine within intracellular vesicles.
- Action potentials prompt the opening of voltage-gated calcium channels.
Types of Agonists
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Beta-Adrenergic Agonists:
- Beta-1 Agonists: Target the heart, increasing heart rate and contractility.
- Beta-1+2 Agonists: Affect both Beta-1 and Beta-2 receptors, providing a broad range of effects.
- Beta-2 Agonists: Primarily cause bronchodilation and vasodilation; used in asthma treatment.
- Beta-3 Agonists: Involved in promoting lipolysis and regulating energy expenditure.
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Alpha+Beta Agonists: Exhibit both alpha and beta adrenergic activity, impacting various physiological responses.
Norepinephrine, Epinephrine, & Isoproterenol
- Norepinephrine has distinct cardiovascular effects compared to epinephrine and isoproterenol.
- Epinephrine generally has a broader range of systemic effects than norepinephrine, influencing both alpha and beta receptors.
- Isoproterenol primarily targets beta receptors, increasing heart rate and decreasing peripheral resistance.
Receptors
- Alpha-1 Receptor: Functions through phospholipase C, resulting in increased intracellular calcium and vasoconstriction.
- Understanding the various receptor types is crucial for pharmacological targeting in cardiovascular and respiratory therapies.
Summary
- Norepinephrine synthesis and its subsequent actions through specific adrenergic receptors play a vital role in autonomic nervous system responses.
- Different agonists have unique effects on cardiovascular and respiratory systems based on their receptor specificity.
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Description
Test your knowledge of autonomic pharmacology with this quiz on adrenergic agonists. Explore the different types of adrenergic receptors and various agonists, including beta-adrenergic agonists and alpha+beta agonists.
