Adrenergic Agonists and Drug Effects
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Questions and Answers

What is the clinical effect of CLONIDINE, an α2 agonist?

  • Increases blood pressure through a peripheral mechanism
  • Decreases heart rate and cardiac output (correct)
  • Increases blood pressure through a central action
  • Relieves bronchoconstriction

How does DOBUTAMINE, a β1 agonist, affect the body?

  • Relieves bronchoconstriction
  • Increases heart rate and cardiac output (correct)
  • Causes renal and coronary vasodilation
  • Decreases heart rate and cardiac output

Which adrenergic agonist is used for the treatment of overactive bladder in adults?

  • Isoproterenol
  • Terbutaline
  • Mirabegron/Vibegron (correct)
  • Phenylephrine

What is the mechanism of action of EPHEDRINE and PHENYLPROPANOLAMINE?

<p>Release previously stored norepinephrine (A)</p> Signup and view all the answers

At what doses does DOPAMINE cause renal and coronary vasodilation?

<p>Low doses (A)</p> Signup and view all the answers

What is the precursor to norepinephrine?

<p>Dopamine (D)</p> Signup and view all the answers

Which drug is a prototypic muscarinic antagonist?

<p>Atropine (B)</p> Signup and view all the answers

What is the effect of muscarinic antagonists on the binding of acetylcholine to the muscarinic receptor?

<p>Inhibition (D)</p> Signup and view all the answers

Which group of drugs increase the concentration of acetylcholine and affect the neuromuscular junction?

<p>Cholinesterase inhibitors (C)</p> Signup and view all the answers

What is the primary effect of cholinesterase inhibitors in Myasthenia Gravis?

<p>Muscle weakness (D)</p> Signup and view all the answers

Which drug is used for urinary retention and acts as a cholinergic agonist?

<p>Bethanechol (C)</p> Signup and view all the answers

What is the primary mechanism of action of cholinergic antagonists like Atropine?

<p>Block acetylcholine binding (A)</p> Signup and view all the answers

Which type of αblockers are reversible inhibitors of the α receptor?

<p>Phentolamine (C)</p> Signup and view all the answers

Which αblocker is an irreversible inhibitor of the α receptor and is used in the treatment of pheochromocytomas?

<p>Phenoxybenzamine (A)</p> Signup and view all the answers

Which of the following is a specific antagonist of the α1A receptor used in the symptomatic treatment of benign prostatic hypertrophy?

<p>Tamsulosin (D)</p> Signup and view all the answers

What is the primary effect of β2 antagonists on smooth muscle?

<p>Constriction (B)</p> Signup and view all the answers

Which class of drugs should be used with caution in diabetics due to their effects?

<p>βBlockers (D)</p> Signup and view all the answers

Which type of βblockers are often referred to as cardioselective due to their action on β1 receptors?

<p>Metoprolol (C)</p> Signup and view all the answers

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