Adrenal Gland Overview and Functions

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Questions and Answers

What is the primary action of mineralocorticoids in the kidney?

  • Na reabsorption (correct)
  • Na secretion
  • H secretion reduction
  • K reabsorption

Which statement correctly identifies the sources of androgens in males?

  • Pituitary gland
  • Mainly testis (correct)
  • Mainly adrenal cortex
  • Mainly ovaries

During an attack of pheochromocytoma, which of the following symptoms is most likely to occur?

  • Tachycardia (correct)
  • Hypoglycemia
  • Bradycardia
  • Hypotension

What is the primary function of adrenaline in relation to cardiac function?

<p>Enhancing cardiac contractility (C)</p> Signup and view all the answers

Which of the following best describes the role of noradrenaline?

<p>Increases blood pressure via vasoconstriction (A)</p> Signup and view all the answers

In females, which of the following is a significant role of androgens?

<p>Conversion into estrogen (A)</p> Signup and view all the answers

Which characteristic is influenced by testosterone in males?

<p>Voice pitch (D)</p> Signup and view all the answers

What is the main function of aldosterone regarding potassium in the kidney?

<p>K secretion (C)</p> Signup and view all the answers

What is the effect of catecholamines on blood pressure?

<p>Increase arterial blood pressure (B)</p> Signup and view all the answers

What is a primary function of glucocorticoids in carbohydrate metabolism?

<p>Promoting gluconeogenesis (B)</p> Signup and view all the answers

In what way do glucocorticoids affect protein metabolism in intra hepatic tissue?

<p>Anabolic effect on plasma proteins (C)</p> Signup and view all the answers

Which condition is associated with chronic exposure to excessive glucocorticoids?

<p>Cushing syndrome (D)</p> Signup and view all the answers

What effect do glucocorticoids have on the vascular system?

<p>Maintain normal blood pressure (B)</p> Signup and view all the answers

What is a clinical use of hydrocortisone in medicine?

<p>To alleviate symptoms of bronchial asthma (C)</p> Signup and view all the answers

Which of the following is NOT a function of cortisol?

<p>Development of muscle hypertrophy (C)</p> Signup and view all the answers

How does glucocorticoids affect the release of glucose from the liver?

<p>Facilitates increased glucose release (A)</p> Signup and view all the answers

What is a key characteristic of Cushing syndrome?

<p>Central obesity with a moon face (D)</p> Signup and view all the answers

Which of the following is a type of hormone secreted by the adrenal medulla?

<p>Adrenaline (D)</p> Signup and view all the answers

What effect do glucocorticoids have on inflammation and bronchial function?

<p>Act as a bronchodilator and reduce inflammation (C)</p> Signup and view all the answers

What role does aldosterone primarily play in relation to renal function?

<p>Facilitates sodium reabsorption (D)</p> Signup and view all the answers

Which of the following best describes a consequence of excessive catecholamine secretion in pheochromocytoma?

<p>Increased anxiety and tachycardia (C)</p> Signup and view all the answers

In males, which physiological process is significantly influenced by androgens?

<p>Spermatogenesis (A)</p> Signup and view all the answers

Which of the following statements about the adrenal medulla is true?

<p>It secretes predominantly adrenaline (C)</p> Signup and view all the answers

What is one of the primary sources of androgens in females?

<p>Adrenal cortex (C)</p> Signup and view all the answers

Which of the following is primarily associated with the action of noradrenaline?

<p>Vasoconstriction to raise blood pressure (D)</p> Signup and view all the answers

Which symptom is typically NOT associated with an adrenal medulla tumor leading to catecholamine overproduction?

<p>Weight gain (D)</p> Signup and view all the answers

What is one of the actions of testosterone in females?

<p>Enhances adipose tissue conversion to estrogen (A)</p> Signup and view all the answers

Which of the following is a significant role of adrenaline?

<p>Increasing cardiac output (C)</p> Signup and view all the answers

Which statement accurately describes the effect of glucocorticoids on muscle tissue?

<p>They are exclusively catabolic in extra hepatic tissue. (C)</p> Signup and view all the answers

What is a significant clinical sign of Cushing syndrome related to fat redistribution?

<p>Central obesity with facial changes like moon face. (A)</p> Signup and view all the answers

How do glucocorticoids contribute to the maintenance of arterial blood pressure?

<p>By enhancing myocardial contractility and reducing vascular permeability. (D)</p> Signup and view all the answers

What role do glucocorticoids play in protein metabolism in intra hepatic tissues?

<p>They encourage the synthesis of plasma proteins. (A)</p> Signup and view all the answers

Which of the following statements is true regarding the effect of glucocorticoids during stress?

<p>They increase glucose production and release from the liver. (A)</p> Signup and view all the answers

What is a potential consequence of prolonged exposure to glucocorticoids on blood glucose levels?

<p>Hyperglycemia resulting from increased gluconeogenesis. (A)</p> Signup and view all the answers

Which of the following is NOT a recognized function of glucocorticoids?

<p>Enhancing immune response. (D)</p> Signup and view all the answers

Which treatment is commonly used to address bronchial asthma and allergic conditions?

<p>Hydrocortisone. (B)</p> Signup and view all the answers

What metabolic effect does cortisol have on fat stores?

<p>It leads to lipolysis and reduces fat stores. (C)</p> Signup and view all the answers

In relation to vascular endothelial permeability, how do glucocorticoids influence this factor?

<p>They decrease permeability, stabilizing the vascular system. (C)</p> Signup and view all the answers

Which of the following is an action of mineralocorticoids in the kidney?

<p>Enhances Na reabsorption (A)</p> Signup and view all the answers

Which physiological characteristic is directly influenced by androgens in males?

<p>Development of facial hair (D)</p> Signup and view all the answers

How does adrenaline primarily affect cardiac function?

<p>Increases cardiac output (A)</p> Signup and view all the answers

What is a notable effect of excessive catecholamines in a patient with pheochromocytoma?

<p>Severe anxiety (C)</p> Signup and view all the answers

Which source supplies most of the androgens in males?

<p>Testis (C)</p> Signup and view all the answers

What distinguishes noradrenaline from adrenaline in their action on blood pressure?

<p>Primarily induces vasoconstriction (A)</p> Signup and view all the answers

Which physiological role does androgen play in females?

<p>Promotes axillary and pubic hair growth (B)</p> Signup and view all the answers

What effect does adrenaline have on the body's metabolic rate?

<p>Enhances oxygen utilization (A)</p> Signup and view all the answers

During an attack of pheochromocytoma, which symptom is commonly observed?

<p>Severe headache (B)</p> Signup and view all the answers

Which statement best describes the influence of glucocorticoids on carbohydrate metabolism?

<p>They promote the increase of glucose release from the liver. (B)</p> Signup and view all the answers

What is a recognizable clinical feature of Cushing syndrome related to fat distribution?

<p>Central obesity with a moon face appearance. (B)</p> Signup and view all the answers

How do glucocorticoids affect muscle tissues, particularly in extra hepatic locations?

<p>They exert a catabolic effect resulting in muscle breakdown. (D)</p> Signup and view all the answers

Which effect of glucocorticoids is crucial for maintaining blood pressure?

<p>Decreasing the permeability of vascular endothelium. (C)</p> Signup and view all the answers

What metabolic role does cortisol primarily play in fat metabolism?

<p>Initiating lipolysis to mobilize fatty acids. (D)</p> Signup and view all the answers

What is the effect of chronic exposure to glucocorticoids on blood glucose levels?

<p>It causes hyperglycemia due to increased glucose release. (A)</p> Signup and view all the answers

Which of the following does NOT represent a function of glucocorticoids?

<p>Enhancement of inflammatory responses. (B)</p> Signup and view all the answers

What is a common clinical use of hydrocortisone in medical practice?

<p>Relief for bronchial asthma and allergic reactions. (A)</p> Signup and view all the answers

In which way do glucocorticoids impact the production of vasodilator prostaglandins?

<p>They decrease production, which conserves blood flow. (B)</p> Signup and view all the answers

What characterizes the muscle effect of glucocorticoids in intra hepatic tissue?

<p>They predominantly lead to protein breakdown. (B)</p> Signup and view all the answers

Which statement accurately describes the action of mineralocorticoids in the kidney?

<p>Promotes sodium reabsorption and potassium secretion (C)</p> Signup and view all the answers

What is the predominant source of androgens in females?

<p>Adrenal cortex (D)</p> Signup and view all the answers

Which of the following hormones is primarily responsible for increased cardiac contractility?

<p>Adrenaline (B)</p> Signup and view all the answers

In patients with pheochromocytoma, what symptom is least likely to be observed?

<p>Bradycardia (A)</p> Signup and view all the answers

What is the role of androgens in male physiology?

<p>Spermatogenesis and development of secondary sexual traits (A)</p> Signup and view all the answers

Which receptor subtype mediates the effect of noradrenaline on arterial blood pressure?

<p>α1 (B)</p> Signup and view all the answers

What is the effect of excessive adrenaline on metabolic processes?

<p>Increase in energy expenditure (B)</p> Signup and view all the answers

Which statement best describes the action of testosterone in females?

<p>It is converted into estrogen in adipose tissue (B)</p> Signup and view all the answers

Which of the following is a clinical feature associated with pheochromocytoma?

<p>Anxiety and panic attacks (A)</p> Signup and view all the answers

What is one of the metabolic functions of glucocorticoids in carbohydrate metabolism?

<p>Promote gluconeogenesis (B)</p> Signup and view all the answers

Which symptom is typically associated with Cushing syndrome due to chronic exposure to glucocorticoids?

<p>Moon face with central obesity (C)</p> Signup and view all the answers

How do glucocorticoids affect vascular permeability?

<p>Decrease permeability of vascular endothelium (C)</p> Signup and view all the answers

What is a key clinical use of hydrocortisone?

<p>Address bronchial asthma and allergic conditions (B)</p> Signup and view all the answers

What metabolic effect do glucocorticoids have on protein metabolism in muscle tissues?

<p>Exhibit catabolic effects (B)</p> Signup and view all the answers

In terms of adrenal hormones, which option describes catecholamines' major action?

<p>Increase heart rate and blood pressure (A)</p> Signup and view all the answers

What is a significant consequence of prolonged glucocorticoid exposure on glucose levels?

<p>Hyperglycemia due to increased gluconeogenesis (B)</p> Signup and view all the answers

Which of the following statements about the effect of glucocorticoids during stress is correct?

<p>They increase availability of energy substrates (C)</p> Signup and view all the answers

Which metabolic function is NOT associated with glucocorticoids?

<p>Glycogenesis in the liver (A)</p> Signup and view all the answers

What role do glucocorticoids play in the vascular system?

<p>Support normal arterial blood pressure (A)</p> Signup and view all the answers

Flashcards

Cortisol

A hormone secreted by the adrenal cortex that plays a crucial role in regulating metabolism, stress response, and inflammation.

Gluconeogenesis

The process of producing glucose from non-carbohydrate sources like proteins and fats. It is stimulated by cortisol.

Catabolism of muscle proteins

A process where cortisol breaks down muscle protein to provide energy for the body.

Anabolism of plasma proteins

A process where cortisol stimulates the production of plasma proteins in the liver.

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Lipolysis

A type of fat breakdown stimulated by cortisol, releasing fatty acids for energy.

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Increase glucose release from the liver

The breakdown of glycogen stores in the liver, releasing glucose into the bloodstream, triggered by cortisol.

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Cushing Syndrome

A condition caused by prolonged exposure to high levels of cortisol, leading to symptoms like weight gain, muscle weakness, and skin changes.

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Hydrocortisone

A medication containing hydrocortisone, a synthetic cortisol, used to treat inflammatory conditions like asthma and allergies.

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Glucocorticoids

A group of hormones produced by the adrenal cortex, including cortisol. They regulate a wide range of bodily functions.

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Adrenal Medulla

The inner part of the adrenal gland, responsible for producing adrenaline and noradrenaline.

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Aldosterone

A hormone produced by the adrenal cortex that helps regulate blood pressure and electrolyte balance.

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Aldosterone: Sodium Reabsorption

Aldosterone's main action in the kidneys involves reabsorbing sodium (Na+) from the urine.

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Aldosterone: Potassium Secretion

Aldosterone also promotes the secretion of potassium (K+) into the urine.

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Aldosterone: Hydrogen Secretion

Aldosterone also helps in removing hydrogen ions (H+) from the body.

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Testosterone

A male sex hormone essential for key functions like sperm production and development of physical male characteristics.

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Testosterone: Erythropoiesis

Testosterone is vital for the production of red blood cells in both males and females.

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Testosterone: Secondary Sex Characteristics

Testosterone plays a crucial role in developing secondary sex characteristics, such as facial hair, deep voice, and muscle mass.

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Pheochromocytoma

A tumor of the adrenal medulla that causes excessive production of epinephrine and norepinephrine.

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Epinephrine (Adrenaline)

The primary hormone secreted by the adrenal medulla that regulates heart rate and blood pressure.

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What is aldosterone?

Aldosterone is a hormone produced by the adrenal cortex, mainly responsible for regulating blood volume and electrolyte balance. It acts on the kidneys to promote sodium (Na+) reabsorption, potassium (K+) secretion, and hydrogen (H+) removal.

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What is the primary action of aldosterone in the kidneys?

Aldosterone's main action is to increase sodium reabsorption in the kidneys, contributing to the retention of water and maintaining blood pressure.

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Besides sodium, what else does aldosterone act on in the kidneys?

Aldosterone also promotes the secretion of potassium into the urine, helping to regulate the levels of this important electrolyte.

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What other action does aldosterone have in the kidneys related to pH?

Aldosterone can also stimulate the excretion of hydrogen ions in the urine, contributing to acid-base balance in the body.

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What is a key role of testosterone in both sexes?

Testosterone, the primary male sex hormone, is vital for the production of red blood cells (erythropoiesis) in both men and women.

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What is a crucial role of testosterone in men specifically?

In males, testosterone is essential for spermatogenesis, the process of sperm cell formation.

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What are some key characteristics testosterone influences in males?

Testosterone contributes to the development of male secondary sex characteristics, such as a deep voice, facial hair, and a more muscular build.

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What happens to testosterone in women?

In females, testosterone is converted into estrogen in adipose tissue. While estrogen is the primary female sex hormone, testosterone is still important for female health.

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What are the primary hormones secreted by the adrenal medulla?

The adrenal medulla, the inner part of the adrenal gland, primarily secretes two hormones: adrenaline (epinephrine) and noradrenaline (norepinephrine). These hormones are crucial for the 'fight-or-flight' response and are involved in regulating heart rate, blood pressure, and various other physiological functions.

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What is cortisol?

The primary hormone secreted by the adrenal cortex that plays a crucial role in regulating metabolism, stress response, and inflammation.

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What is gluconeogenesis?

Cortisol stimulates the production of glucose from non-carbohydrate sources like proteins and fats.

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How does cortisol affect muscle proteins?

Cortisol breaks down muscle proteins for energy. This happens due to the body's need to use alternative energy sources in stressful situations.

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What happens to plasma proteins in the liver under cortisol's influence?

Cortisol promotes the production of plasma proteins (proteins in the blood) in the liver. Plasma proteins help with various bodily functions like transporting substances and maintaining blood volume.

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What happens to fat storage under the influence of cortisol?

Cortisol triggers the breakdown of fats (lipolysis), releasing fatty acids into the bloodstream that can be used for energy. This is part of the body's stress response, aiming to provide fuel.

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How do glucocorticoids like cortisol regulate blood pressure?

Glucocorticoids help maintain normal arterial blood pressure by influencing heart muscle strength (myocardial contractility) and reducing substances that dilate blood vessels (vasodilator prostaglandins). This helps regulate blood flow.

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What are some of the key actions of glucocorticoids like cortisol?

Glucocorticoids can reduce inflammation by blocking the release of substances that trigger inflammation. They also have a bronchodilator effect, opening up airways. This makes them useful in treating conditions like asthma.

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What is Cushing syndrome?

Cushing syndrome occurs when the body is chronically exposed to high levels of cortisol, leading to symptoms like weight gain, muscle weakness, and changes in fat distribution (moon face, thin extremities).

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What is hydrocortisone?

Hydrocortisone is a synthetic version of cortisol, commonly used to treat a variety of inflammatory conditions including bronchial asthma (difficulty breathing) and allergic reactions.

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What is the role of the adrenal medulla?

The adrenal medulla is the inner part of the adrenal gland, mainly responsible for producing adrenaline (epinephrine) and noradrenaline (norepinephrine). These hormones are crucial for the 'fight-or-flight' response.

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What is the main action of aldosterone in the kidneys?

It increases sodium reabsorption in the kidneys, which leads to water retention and helps maintain blood pressure.

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Besides sodium, what else does aldosterone affect in the kidneys?

It also promotes the secretion of potassium into the urine, helping to control potassium levels.

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How does aldosterone influence blood pressure?

Aldosterone helps regulate blood pressure by acting on the kidneys to control sodium reabsorption.

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What is a crucial role of testosterone in men?

It is essential for spermatogenesis, the process of sperm cell formation.

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What is a pheochromocytoma?

It is a tumor of the adrenal medulla that causes excessive production of adrenaline and noradrenaline.

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What is the adrenal cortex?

The outer layer of the adrenal gland that produces hormones like cortisol, aldosterone, and androgens.

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What role does aldosterone play?

A hormone produced by the adrenal cortex responsible for regulating blood pressure and electrolyte balance. It works by affecting sodium and potassium levels in the kidneys.

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What is the function of cortisol?

A hormone produced by the adrenal cortex that helps regulate carbohydrate, protein, and fat metabolism. It also has anti-inflammatory and bronchodilator effects.

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What is catabolism of muscle proteins?

A process where cortisol breaks down muscle proteins to provide energy for the body. This happens during stressful situations.

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What is anabolism of plasma proteins?

A process where cortisol stimulates the production of plasma proteins in the liver, which helps with various bodily functions.

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What is lipolysis?

The breakdown of fat stores, releasing fatty acids for energy. This is stimulated by cortisol during stressful situations.

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What is the adrenal medulla?

The inner part of the adrenal gland responsible for producing adrenaline and noradrenaline, hormones that are crucial for the body's 'fight-or-flight' response.

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What are glucocorticoids?

A group of hormones produced by the adrenal cortex, including cortisol. They regulate a wide range of bodily functions.

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Study Notes

Adrenal Gland Overview

  • Located above the kidneys.
  • Adrenal cortex produces corticosteroids: mineralocorticoids, glucocorticoids, and androgens.
  • Adrenal medulla produces catecholamines (adrenaline and noradrenaline).

Adrenal Cortex

  • Produces hormones for various bodily functions.
  • Glucocorticoids (e.g., cortisol): Regulate carbohydrate, protein, and fat metabolism, blood pressure, and inflammation. Maintain normal arterial blood pressure through maintaining myocardial contractility, reducing vasodilator prostaglandin production, and decreasing vascular permeability. Has bronchodilator and anti-inflammatory effects.
  • Mineralocorticoids (e.g., aldosterone): Regulate sodium and potassium levels by increasing sodium reabsorption and potassium secretion in the kidneys.
  • Androgens (sex hormones): Develop secondary sexual characteristics, crucial for spermatogenesis and erythropoiesis in males. In females, converted to estrogen. The adrenal cortex is a source of androgens in both males and females, with the testes being the primary source in males.

Glucocorticoids (Cortisol)

  • Released under ACTH (adrenocorticotropic hormone) influence.
  • Functions include gluconeogenesis, protein metabolism (catabolic in extra-hepatic tissue, anabolic in intra-hepatic tissue), fat metabolism, and cardiovascular effects. Important for maintaining internal stability.

Clinical Applications of Glucocorticoids

  • Cushing's syndrome: Excessive glucocorticoids result in hyperglycemia, muscle weakness, central obesity (moon face), and thin extremities. Stretch marks, thinning hair, and bruising also occur.
  • Treatment of bronchial asthma and allergic conditions: Hydrocortisone is used.

Mineralocorticoids (Aldosterone)

  • Acts on the kidneys for sodium reabsorption and potassium secretion.
  • Increases serum sodium levels (by 4-6 mEq/L).
  • Regulates fluid balance and blood pressure.

Androgens

  • Essential for erythropoiesis and spermatogenesis in males.
  • Contribute to secondary sex characteristics (e.g., facial hair, voice).
  • In females, converted into estrogen.
  • Primarily produced in the testes, but also present in the adrenal cortex.
  • Adrenal cortex is a source of androgens in both males and females, testes being the primary source in males.

Adrenal Medulla

  • Secretes 80% adrenaline and 20% noradrenaline.
  • Adrenaline and noradrenaline affect cardiac contractility, blood pressure, blood vessel constriction and dilation, and heart rate.
  • Pheochromocytoma: A tumor in the adrenal medulla that leads to excessive catecholamine production, causing tachycardia, hypertension, and anxiety.

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