Chapter 20 |Adrenal Gland
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Chapter 20 |Adrenal Gland

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Questions and Answers

Which zone of the adrenal cortex is responsible for aldosterone biosynthesis?

Zona Glomerulosa

What type of hormones are synthesized by the adrenal medulla?

Catecholamines

What is the half-life of catecholamines in the circulation?

2 minutes

What are the metabolic effects of norepinephrine and epinephrine?

<p>Mobilization of free fatty acids</p> Signup and view all the answers

What is the precursor of all steroids?

<p>Cholesterol</p> Signup and view all the answers

Where is cholesterol transported for conversion to pregnenolone?

<p>Mitochondria</p> Signup and view all the answers

What is the name of the α globulin that binds cortisol in the circulation?

<p>Transcortin</p> Signup and view all the answers

Which hormone activates adenylyl cyclase via Gs receptors in adrenocortical cells?

<p>ACTH</p> Signup and view all the answers

Which hormones of the adrenal cortex are derivatives of cholesterol?

<p>Cortisol and dehydroepiandrosterone</p> Signup and view all the answers

During sleep, which catecholamines are reduced in secretion?

<p>Epinephrine and norepinephrine</p> Signup and view all the answers

What is the 'emergency function of the sympathoadrenal system' according to Cannon?

<p>Increased adrenal medullary secretion</p> Signup and view all the answers

Which steroids are normally secreted in physiologically significant amounts from adrenal tissue?

<p>Cortisol and dehydroepiandrosterone</p> Signup and view all the answers

What are the two classes of receptors that norepinephrine and epinephrine act on?

<p>α- and β-adrenergic receptors</p> Signup and view all the answers

Which hormone is an important source of estrogens in men and postmenopausal women?

<p>Androstenedione</p> Signup and view all the answers

What stimulates glucocorticoid secretion from the adrenal cortex?

<p>Adrenocorticotropic hormone (ACTH)</p> Signup and view all the answers

Which hormone increases the excretion of Na+ and K+?

<p>Aldosterone</p> Signup and view all the answers

Which adrenal cortical zone is responsible for aldosterone biosynthesis?

<p>Zona glomerulosa</p> Signup and view all the answers

What is the primary function of the adrenal medulla?

<p>Synthesis of catecholamines</p> Signup and view all the answers

Which hormones are conjugated to sulfate in plasma?

<p>Norepinephrine</p> Signup and view all the answers

What are the metabolic effects of norepinephrine and epinephrine?

<p>Mobilization of free fatty acids</p> Signup and view all the answers

Which hormones of the adrenal cortex are involved in glucose and protein metabolism?

<p>Cortisol and corticosterone</p> Signup and view all the answers

What is the precursor of estrogens in men and postmenopausal women?

<p>Dehydroepiandrosterone (DHEA)</p> Signup and view all the answers

Which hormone increases the excretion of sodium (Na+) and potassium (K+)?

<p>Aldosterone</p> Signup and view all the answers

What stimulates the secretion of glucocorticoids from the adrenal cortex?

<p>Stress</p> Signup and view all the answers

What is the effect of glucocorticoids on ACTH secretion?

<p>Inhibit ACTH secretion</p> Signup and view all the answers

In patients with adrenal insufficiency who have not received glucocorticoids, what reaction may glucose infusion cause?

<p>High fever ('glucose fever') followed by collapse and death</p> Signup and view all the answers

What personality changes are associated with adrenal insufficiency that are reversed by glucocorticoids?

<p>Irritability, apprehension, and inability to concentrate</p> Signup and view all the answers

How do glucocorticoids affect water metabolism in adrenal insufficiency?

<p>Cause water intoxication</p> Signup and view all the answers

What is the primary action of mineralocorticoids like aldosterone on Na+ reabsorption?

<p>Increase Na+ reabsorption from urine and other bodily fluids</p> Signup and view all the answers

What happens when aldosterone binds to its cytoplasmic receptor in the cell?

<p>It increases the synthesis of ENaCs</p> Signup and view all the answers

How do mineralocorticoids affect potassium (K+) excretion in the renal tubules?

<p>Produce a K+ diuresis</p> Signup and view all the answers

What is the mechanism through which aldosterone-stimulated proteins affect sodium reabsorption?

<p>Enhance the synthesis of ENaCs</p> Signup and view all the answers

Which type of adrenergic receptors mediate the vasoconstriction produced by norepinephrine?

<p>α1-receptors</p> Signup and view all the answers

What is the effect of dopamine on renal vasculature?

<p>Vasodilation</p> Signup and view all the answers

Which adrenergic receptor mediates the positive inotropic effect of dopamine on the heart?

<p>β1-receptors</p> Signup and view all the answers

What is the physiological function of dopamine in the circulation?

<p>Unknown</p> Signup and view all the answers

During emergency situations, which part of the adrenal gland secretes increased amounts of hormones like epinephrine and norepinephrine?

<p>Adrenal Medulla</p> Signup and view all the answers

Which hormone is NOT normally secreted in physiologically significant amounts from adrenal tissue?

<p>Aldosterone</p> Signup and view all the answers

Which nucleus is found in the structure of hormones derived from the adrenal cortex?

<p>Cyclopentanoperhydrophenanthrene Nucleus</p> Signup and view all the answers

What is the primary function of the mineralocorticoid aldosterone?

<p>Regulating Sodium and Potassium Levels</p> Signup and view all the answers

Which hormone is the most active androgen secreted from the testes?

<p>Testosterone</p> Signup and view all the answers

What controls the acute secretion of adrenal androgens?

<p>ACTH</p> Signup and view all the answers

What happens when adrenal androgens are secreted in excessive amounts in males?

<p>They cause masculinization effects</p> Signup and view all the answers

How do glucocorticoids affect glucose metabolism?

<p>Increase hepatic glycogenesis</p> Signup and view all the answers

What effect does free glucocorticoids have on ACTH secretion?

<p>Inhibits ACTH secretion</p> Signup and view all the answers

Why can administering steroids not produce the effects of high levels of circulating glucocorticoids?

<p>Steroids result in other manifestations of glucocorticoid excess</p> Signup and view all the answers

Which hormone is responsible for increasing the sensitivity of the adrenal to subsequent doses of ACTH?

<p>ACTH</p> Signup and view all the answers

When does most of the daily production of cortisol occur in humans?

<p>Between 4:00 AM and 10:00 AM</p> Signup and view all the answers

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