6 Questions
What integrin is in a low affinity state on naive T cells and increases in strength upon antigen recognition?
LFA-1
Which proteins on APCs are recognized by T cell receptor for costimulation, leading to T cell proliferation?
B7-1 and B7-2
Which protein binds to either B7-1 and B7-2, serving as a coinhibitor to limit immune responses?
CTLA-4
Which inducible costimulator binds to ICOS-L and functions for the development of follicular helper T cells?
ICOS
Which receptor binds to PD-L1 and PD-L2, serving as a coinhibitor to limit immune responses?
ICOS-L
What is the role of inhibitory receptors in the immune response?
Limit and terminate immune responses
Explore the role of adhesion molecules such as LFA-1 integrin in T cell responses and the importance of costimulation for T cell activation. Learn how integrin-mediated adhesion facilitates T cell interactions with APCs and the significance of costimulators like CD28 and B7 proteins.
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