Adenovirus Overview
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Questions and Answers

Which of the following are potential targets for treatment of adenoviral infections?

  • AdV Lipid kinase
  • AdV RNA polymerase
  • AdV Ribosomal protein
  • AdV Cysteine protease (correct)
  • What is a method mentioned in the text for laboratory diagnosis of adenoviral infections?

  • Urine culture
  • Stool culture (correct)
  • Skin patch test
  • Blood culture
  • Which of the following is mentioned as a complication of adenoviral infections?

  • Typhoid
  • Hepatitis
  • Malaria
  • Meningitis (correct)
  • What test can be used to detect the virus in nasopharyngeal or ocular specimens?

    <p>Immunofluorescence</p> Signup and view all the answers

    How can adenoviral infections be prevented?

    <p>Vaccines</p> Signup and view all the answers

    What is a potential antiviral drug mentioned in the text for the treatment of adenoviral infections?

    <p>Ganciclovir</p> Signup and view all the answers

    What is the morphology of Adenoviruses?

    <p>Icosahedral shape with 252 capsomeres and fibre projects from each of 12 vertices</p> Signup and view all the answers

    How do Adenoviruses replicate?

    <p>In the nucleus</p> Signup and view all the answers

    How are Adenoviruses commonly transmitted?

    <p>Via contact with droplets from an infected person's nose or throat</p> Signup and view all the answers

    What symptoms are most commonly associated with Adenovirus infections?

    <p>Respiratory symptoms like sore throat, cough, and runny nose</p> Signup and view all the answers

    How do Adenoviruses differ from other viruses based on their genome?

    <p>Double stranded DNA</p> Signup and view all the answers

    Study Notes

    Adenovirus Characteristics

    • Medium-sized, non-enveloped, double-stranded DNA viruses
    • Share a common complement fixing antigen
    • Infect both humans and animals
    • Most infections are asymptomatic, especially in children
    • Icosahedral shape, approximately 80-110 mm in diameter, with 252 capsomeres
    • Fibre projects from each of 12 vertices, resembling a space ship

    Classification

    • Family: Adenoviridae
    • Genus: Mastadenovirus (adenovirus of mammals)
    • Species: Human adenovirus
    • At least 52 distinct antigenic types isolated from humans, many more from animals
    • Human adenovirus divided into seven groups (A-G)

    Disease Associations

    • Transmission: Contact with droplets from the nose and throat of an infected person (e.g., during coughing or sneezing) or by touching hands/an object
    • Symptoms: Cold-like symptoms, including sore throat, sneezing, runny nose, cough, headache, chills, or symptoms of croup or bronchitis
    • Complications: Ear infections, pneumonia, or meningitis (inflammation of the brain and spinal cord)
    • Lasts: 3-5 days, but serious infections can last for weeks

    Laboratory Diagnosis

    • Specimen sources: Throat, eye, urine, feces
    • Isolation of virus: Inoculation into cell cultures (human embryonic kidney, HeLa, HeP2), with characteristic cytopathic effects (CPE) of cell rounding and aggregation into grape-like clusters
    • Other tests: Hemadsorption (HA), Neutralization, Complement Fixation (CF) Serology, and Electron Microscopy (for stool)

    Treatment and Prevention

    • Potential targets: AdV DNA polymerase, AdV Cysteine protease, and receptors for binding host cells
    • Antivirals in use: Ribavirin, Cidofovir, Ganciclovir, and Vidarabine
    • Prevention: Vaccines available for adenovirus serotypes 4 and 7 (preventing ARD among military recruits), strict attention to good infection-control practices

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    Description

    This quiz provides an overview of adenoviruses, including their discovery, replication, classification, and common characteristics. Learn about the structure, classification, and prevalence of adenoviruses.

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