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What is the trade name of Adenosine?
What is the trade name of Adenosine?
What is the classification of Adenosine?
What is the classification of Adenosine?
Endogenous nucleoside, miscellaneous antidysrhythmic
What is the mechanism of action of Adenosine?
What is the mechanism of action of Adenosine?
It decreases electrical conduction through the AV node and acts on sinus pacemaker cells.
What are the indications for Adenosine?
What are the indications for Adenosine?
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What are the contraindications for Adenosine?
What are the contraindications for Adenosine?
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Which of the following are adverse reactions of Adenosine? (Select all that apply)
Which of the following are adverse reactions of Adenosine? (Select all that apply)
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What are the drug interactions associated with Adenosine?
What are the drug interactions associated with Adenosine?
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What is the dosage and administration of Adenosine for adults?
What is the dosage and administration of Adenosine for adults?
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What is the onset and duration of Adenosine?
What is the onset and duration of Adenosine?
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What are the special considerations for administering Adenosine?
What are the special considerations for administering Adenosine?
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Study Notes
Adenosine Overview
- Trade name: Adenocard
- Classification: Endogenous nucleoside, miscellaneous antidysrhythmic
Mechanism of Action
- Formed from the breakdown of adenosine triphosphate (ATP); present in every cell.
- Decreases electrical conduction through the AV node to slow supraventricular tachycardia without negative inotropic effects.
- Acts directly on sinus pacemaker cells and vagal nerve terminals to reduce heart rate.
- First-line treatment for paroxysmal supraventricular tachycardia (SVT) and assists in diagnostics for wide complex tachycardia.
Indications
- First-line treatment for narrow-complex PSVT and dysrhythmias associated with bypass tracts, such as Wolff-Parkinson-White syndrome in adults and children.
Contraindications
- Ineffective in converting rhythms like atrial flutter and fibrillation; contraindicated in second or third-degree AV block, Sick Sinus Syndrome, hypersensitivity, and V-tach.
Adverse Reactions
- Possible reactions include lightheadedness, paresthesia, headache, diaphoresis, palpitations, chest pain, flushing, hypotension, shortness of breath (SOB), transient bradycardia, ventricular ectopy, nausea/vomiting (N/V).
Drug Interactions
- Methylxanthines (caffeine, theophylline) can antagonize adenosine effects.
- Dipyridamole may necessitate lower doses as it can enhance adenosine effects.
- Carbamazepine might intensify adenosine's AV nodal blocking effects.
Dosage and Administration
- Adults: Initial dose of 6 mg IV bolus over 1-3 seconds, followed by a 20 ml flush. If no response in 1-2 minutes, a 12 mg repeat dose can be administered similarly.
- Pediatrics: Initial dose of 0.1 mg/kg, may double once with a maximum of 6 mg, given as a rapid IV bolus followed by a 5 ml flush.
Onset and Duration
- Effects of IV administration are immediate, lasting approximately 10 seconds.
Special Considerations
- Position the patient in slight reverse Trendelenburg before administration to optimize outcomes. Be prepared for a brief period of asystole during administration.
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Test your knowledge on adenosine with these flashcards. Learn about its trade name, classification, and mechanism of action. Perfect for pharmacology students or medical professionals looking to refresh their knowledge.
