Addison Disease and Hypoadrenocorticism
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Questions and Answers

What is the most common age group in which Addison disease (hypoadrenocorticism) is seen?

  • Puppies
  • Young to middle-aged dogs (correct)
  • Elderly dogs
  • All age groups equally

What is the primary cause of adrenocortical failure in cases of Addison disease?

  • Adrenal enzyme inhibitors (trilostane)
  • Metastatic tumor
  • Autoimmune process (correct)
  • Hemorrhage

Why is isolated glucocorticoid insufficiency likely underdiagnosed?

  • Because it primarily affects elderly dogs
  • Due to the presence of electrolyte abnormalities
  • Because it presents with pathognomonic clinical signs
  • As a result of vague and fluctuating clinical signs (correct)

What is required for confirming the diagnosis of hypoadrenocorticism?

<p>Adrenal function testing using the ACTH stimulation test (D)</p> Signup and view all the answers

Which of the following clinical signs is most commonly associated with isolated glucocorticoid insufficiency in older dogs?

<p>Hypoalbuminemia (D)</p> Signup and view all the answers

What is the principal mineralocorticoid whose reduction in secretion results in marked alterations of serum levels of potassium, sodium, and chloride?

<p>Aldosterone (B)</p> Signup and view all the answers

Which of the following ECG changes may occur in dogs with hyperkalemia?

<p>Tall T wave (D)</p> Signup and view all the answers

What is the most common abnormality in dogs with glucocorticoid and mineralocorticoid insufficiency?

<p>Bilateral idiopathic adrenocortical atrophy (D)</p> Signup and view all the answers

What does a sodium:potassium ratio of < 25:1 indicate in the evaluation of adrenal function?

<p>Addison's disease (D)</p> Signup and view all the answers

What is the suspected immune-mediated pathogenesis associated with idiopathic adrenocortical insufficiency in young, female adult dogs?

<p>Antibody-mediated destruction of adrenal cortex cells (D)</p> Signup and view all the answers

Which of the following may contribute to the development of moderate hypoglycemia in dogs with decreased production of glucocorticoids?

<p>Decreased gluconeogenesis (C)</p> Signup and view all the answers

'A destructive pituitary lesion that decreases ACTH secretion is characterized by severe atrophy of which part of the adrenal gland?'

<p>Zona reticularis (C)</p> Signup and view all the answers

What does a normocytic, normochromic anemia indicate in the evaluation of adrenal function?

<p>Non-specific finding in Addison's disease (A)</p> Signup and view all the answers

What is the main focus of successful treatment for hypoadrenocorticism?

<p>Rapid restoration of blood volume (B)</p> Signup and view all the answers

Which hormone is used for long-term maintenance therapy in dogs with hypoadrenocorticism?

<p>Desoxycorticosterone pivalate (DOCP) (D)</p> Signup and view all the answers

What should be administered if a dog with hypoadrenocorticism is hypoglycemic?

<p>10% glucose in 0.9% saline (D)</p> Signup and view all the answers

How often should serum electrolytes be monitored in dogs receiving fludrocortisone acetate for hypoadrenocorticism?

<p>Weekly (C)</p> Signup and view all the answers

What is the initial management of shock in dogs with hypoadrenocorticism?

<p>Rapid restoration of blood volume (A)</p> Signup and view all the answers

What hormone may be used to help with electrolyte imbalances and hypovolemia in dogs with hypoadrenocorticism?

<p>Desoxycorticosterone pivalate (DOCP) (B)</p> Signup and view all the answers

What test effectively excludes the diagnosis of hypoadrenocorticism if baseline cortisol concentrations are >2.0 mcg/dL?

<p>ACTH stimulation testing (A)</p> Signup and view all the answers

What is administered if a dog with severe, nonresponsive hyperkalemia requires increased potassium movement into the cells?

<p>$10%$ glucose in $0.9%$ saline (A)</p> Signup and view all the answers

What hormone should be administered if a dog is hypoglycemic and needs enhanced glucose and potassium uptake?

<p>$10%$ glucose in $0.9%$ saline concurrently with regular insulin injection (D)</p> Signup and view all the answers

What hormone specifically will not interfere with cortisol measurements during the ACTH stimulation test?

<p>$Prednisolone sodium succinate or dexamethasone sodium phosphate (B)</p> Signup and view all the answers

What is NOT true about the treatment of horses with hypoadrenocorticism?

<p>Replacement of fluids, steroids, and glucose if needed is similar to that in dogs. (B)</p> Signup and view all the answers

How often should dogs be reexamined after a diagnosis of chronic hypoadrenocorticism?

<p>Every 3 months (D)</p> Signup and view all the answers

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