Addison Disease and Hypoadrenocorticism
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Questions and Answers

What is the most common age group in which Addison disease (hypoadrenocorticism) is seen?

  • Puppies
  • Young to middle-aged dogs (correct)
  • Elderly dogs
  • All age groups equally
  • What is the primary cause of adrenocortical failure in cases of Addison disease?

  • Adrenal enzyme inhibitors (trilostane)
  • Metastatic tumor
  • Autoimmune process (correct)
  • Hemorrhage
  • Why is isolated glucocorticoid insufficiency likely underdiagnosed?

  • Because it primarily affects elderly dogs
  • Due to the presence of electrolyte abnormalities
  • Because it presents with pathognomonic clinical signs
  • As a result of vague and fluctuating clinical signs (correct)
  • What is required for confirming the diagnosis of hypoadrenocorticism?

    <p>Adrenal function testing using the ACTH stimulation test</p> Signup and view all the answers

    Which of the following clinical signs is most commonly associated with isolated glucocorticoid insufficiency in older dogs?

    <p>Hypoalbuminemia</p> Signup and view all the answers

    What is the principal mineralocorticoid whose reduction in secretion results in marked alterations of serum levels of potassium, sodium, and chloride?

    <p>Aldosterone</p> Signup and view all the answers

    Which of the following ECG changes may occur in dogs with hyperkalemia?

    <p>Tall T wave</p> Signup and view all the answers

    What is the most common abnormality in dogs with glucocorticoid and mineralocorticoid insufficiency?

    <p>Bilateral idiopathic adrenocortical atrophy</p> Signup and view all the answers

    What does a sodium:potassium ratio of < 25:1 indicate in the evaluation of adrenal function?

    <p>Addison's disease</p> Signup and view all the answers

    What is the suspected immune-mediated pathogenesis associated with idiopathic adrenocortical insufficiency in young, female adult dogs?

    <p>Antibody-mediated destruction of adrenal cortex cells</p> Signup and view all the answers

    Which of the following may contribute to the development of moderate hypoglycemia in dogs with decreased production of glucocorticoids?

    <p>Decreased gluconeogenesis</p> Signup and view all the answers

    'A destructive pituitary lesion that decreases ACTH secretion is characterized by severe atrophy of which part of the adrenal gland?'

    <p>Zona reticularis</p> Signup and view all the answers

    What does a normocytic, normochromic anemia indicate in the evaluation of adrenal function?

    <p>Non-specific finding in Addison's disease</p> Signup and view all the answers

    What is the main focus of successful treatment for hypoadrenocorticism?

    <p>Rapid restoration of blood volume</p> Signup and view all the answers

    Which hormone is used for long-term maintenance therapy in dogs with hypoadrenocorticism?

    <p>Desoxycorticosterone pivalate (DOCP)</p> Signup and view all the answers

    What should be administered if a dog with hypoadrenocorticism is hypoglycemic?

    <p>10% glucose in 0.9% saline</p> Signup and view all the answers

    How often should serum electrolytes be monitored in dogs receiving fludrocortisone acetate for hypoadrenocorticism?

    <p>Weekly</p> Signup and view all the answers

    What is the initial management of shock in dogs with hypoadrenocorticism?

    <p>Rapid restoration of blood volume</p> Signup and view all the answers

    What hormone may be used to help with electrolyte imbalances and hypovolemia in dogs with hypoadrenocorticism?

    <p>Desoxycorticosterone pivalate (DOCP)</p> Signup and view all the answers

    What test effectively excludes the diagnosis of hypoadrenocorticism if baseline cortisol concentrations are >2.0 mcg/dL?

    <p>ACTH stimulation testing</p> Signup and view all the answers

    What is administered if a dog with severe, nonresponsive hyperkalemia requires increased potassium movement into the cells?

    <p>$10%$ glucose in $0.9%$ saline</p> Signup and view all the answers

    What hormone should be administered if a dog is hypoglycemic and needs enhanced glucose and potassium uptake?

    <p>$10%$ glucose in $0.9%$ saline concurrently with regular insulin injection</p> Signup and view all the answers

    What hormone specifically will not interfere with cortisol measurements during the ACTH stimulation test?

    <p>$Prednisolone sodium succinate or dexamethasone sodium phosphate</p> Signup and view all the answers

    What is NOT true about the treatment of horses with hypoadrenocorticism?

    <p>Replacement of fluids, steroids, and glucose if needed is similar to that in dogs.</p> Signup and view all the answers

    How often should dogs be reexamined after a diagnosis of chronic hypoadrenocorticism?

    <p>Every 3 months</p> Signup and view all the answers

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