23 Questions
What is the primary purpose of the differentiation of T cells into effector cells?
To enable the killing of infected cells and microbes
What is the primary function of IL-2 in the context of T cell activation?
To promote the clonal expansion of antigen-specific T cells
What is the primary role of CD8+ T cells in an immune response?
To directly kill infected cells
What is the primary function of dendritic cells in the context of T cell activation?
To present antigens to T cells and initiate an immune response
What is the primary function of memory T cells?
To retain immunological memory for future infections
What is the primary function of T cells in cellular immunity?
To help B cells produce antibodies and interact with other immune cells
What is the role of antigen processing and presentation in cellular immunity?
To present antigens to naïve T cells for recognition
What is the primary difference between humoral immunity and cellular immunity?
Humoral immunity involves B cells and antibodies, while cellular immunity involves T cells and cytokines
What is the role of regulatory T cells in cellular immunity?
To regulate the immune response and prevent autoimmune diseases
What is the result of antigen recognition and binding by T cells?
Activation and signaling of T cells
What is the primary function of adhesion molecules in the binding of T cells to APCs?
To strengthen the binding of T cells to APCs through integrin and selectins
What is the outcome of clonal expansion and differentiation of T cells?
Formation of T memory cells
What is the consequence of T cells not receiving co-stimulatory signals from APCs?
T cells remain in an anergic state
What is the primary function of the TCR complex?
To recognize and bind epitopes associated with MHC proteins
What is the role of CD28 in T cell activation?
To provide co-stimulatory signals to T cells
What is the consequence of calcineurin activation in T cells?
Activation of gene for IL-2 and its receptor
What is the primary role of CD4 and CD8 in T cell activation?
To participate in signaling as co-receptors
What is the primary function of TH1 cells in the immune response?
Produce IFN-gamma to activate cells related to cell-mediated immunity, macrophages, and Abs
What is the mechanism by which cytotoxic T cells induce apoptosis in infected cells?
All of the above
What is the function of Treg cells in the immune response?
Suppress T cells and shut down the immune response
What is the primary function of memory T cells?
Recognize the same antigen and activate the immune response faster
What is the fate of proliferated immune cells after the infection is cleared?
They are deprived of survival factors and die by programmed cell death (apoptosis)
What is the role of Class I MHC molecules in the immune response?
Present antigens to CD8+ T cells
Learn about the different aspects of adaptive immunity, including induced resistance to specific pathogens, humoral and cellular immunity, and the role of T cells and cytokines in combating intracellular infections.
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