18 Questions
What is the most common cause of acute glomerulonephritis in children?
Post-streptococcal glomerulonephritis (PSGN)
What is the primary mechanism of glomerular damage in nephritic syndrome?
All of the above
What is the function of the slit-like diaphragm in the podocytes?
Selective filtration based on size and charge
What is the clinical presentation of nephritic syndrome?
Hematuria, hypertension, and decreased urine output
What is the main component of the glomerular filtration barrier?
Glomerular basement membrane (GBM)
What is the location of the podocytes in the glomerulus?
Visceral layer of the Bowman's capsule
What is the typical latency period between the onset of pharyngitis and the onset of nephritis in Acute Poststreptococcal Glomerulonephritis?
7-21 days
What is the primary mechanism by which the immune complex deposits in the glomerular basement membrane lead to the recruitment of immune cells?
Activation of the complement cascade
What is the most common symptom of Acute Poststreptococcal Glomerulonephritis?
Edema
What is the primary goal of supportive therapy in the management of Acute Poststreptococcal Glomerulonephritis?
Amelioration of volume expansion and hypertension
What is the long-term prognosis of Acute Poststreptococcal Glomerulonephritis in adults?
Not as benign as previously considered, with potential long-term renal damage
What is the primary bacterium responsible for Acute Poststreptococcal Glomerulonephritis?
Group A-beta hemolytic streptococci
What is the characteristic feature of crescentic or rapidly progressive glomerulonephritis (RPGN)?
Sudden and severe acute renal failure
What is the primary site of IgA deposition in IgA Nephropathy?
Glomerular mesangium
What is the temporal relationship between upper respiratory infection and episodes of macroscopic hematuria in IgA Nephropathy?
Episodes of macroscopic hematuria occur in close temporal relationship to upper respiratory infection
What is the indication for ACE inhibitors in IgA Nephropathy?
Proteinuric patients
What is the characteristic feature of Henoch-Schönlein purpura (HSP)?
An acute immunoglobulin A (IgA)–mediated disorder
What is the target of treatment in patients with crescentic IgA Nephropathy?
Elimination of antigenic stimulation
Learn about the sudden onset of nephritic syndrome, caused by group A-beta hemolytic streptococci, and the pathogenesis of Poststreptococcal glomerulonephritis.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
