Podcast
Questions and Answers
What is the most common cause of acute pancreatitis in the United States?
What is the most common cause of acute pancreatitis in the United States?
Which of the following is a mechanism by which gallstones can lead to acute pancreatitis?
Which of the following is a mechanism by which gallstones can lead to acute pancreatitis?
Which symptom is most characteristic of acute pancreatitis?
Which symptom is most characteristic of acute pancreatitis?
What percentage of patients with severe pancreatitis may experience permanent decreases in pancreatic function?
What percentage of patients with severe pancreatitis may experience permanent decreases in pancreatic function?
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Which condition is NOT a recognized cause of acute pancreatitis?
Which condition is NOT a recognized cause of acute pancreatitis?
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In acute pancreatitis, the pain is typically described as:
In acute pancreatitis, the pain is typically described as:
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What is the overall fatality rate associated with severe pancreatitis?
What is the overall fatality rate associated with severe pancreatitis?
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What triggers the autodigestion of the pancreas in acute pancreatitis?
What triggers the autodigestion of the pancreas in acute pancreatitis?
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What is a key preventive measure against respiratory tract infections in patients post-surgery?
What is a key preventive measure against respiratory tract infections in patients post-surgery?
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What is important to teach patients regarding dietary management after acute pancreatitis?
What is important to teach patients regarding dietary management after acute pancreatitis?
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What condition should be monitored for signs in patients recovering from surgery that involves drainage or cyst treatment?
What condition should be monitored for signs in patients recovering from surgery that involves drainage or cyst treatment?
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Why should patients post-acute pancreatitis avoid crash and binge dieting?
Why should patients post-acute pancreatitis avoid crash and binge dieting?
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What type of nurse should be consulted for managing wound care in patients with complications like anastomotic leaks?
What type of nurse should be consulted for managing wound care in patients with complications like anastomotic leaks?
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What is the purpose of using skin barriers in patients recovering from surgery?
What is the purpose of using skin barriers in patients recovering from surgery?
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Which symptom indicates ongoing destruction of pancreatic tissue and pancreatic insufficiency?
Which symptom indicates ongoing destruction of pancreatic tissue and pancreatic insufficiency?
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What is an expected outcome for a patient recovering from acute pancreatitis?
What is an expected outcome for a patient recovering from acute pancreatitis?
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What is often the first position a patient assumes to relieve severe pain associated with acute pancreatitis?
What is often the first position a patient assumes to relieve severe pain associated with acute pancreatitis?
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Which of the following complications is directly associated with the development of a pancreatic pseudocyst?
Which of the following complications is directly associated with the development of a pancreatic pseudocyst?
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What symptom is indicative of severe disease due to hypocalcemia during acute pancreatitis?
What symptom is indicative of severe disease due to hypocalcemia during acute pancreatitis?
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What common diagnostic tests are used to confirm acute pancreatitis?
What common diagnostic tests are used to confirm acute pancreatitis?
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Which complication is often associated with the extensive necrosis occurring in pancreatitis?
Which complication is often associated with the extensive necrosis occurring in pancreatitis?
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What is typically the effect of trypsin on patients with acute pancreatitis?
What is typically the effect of trypsin on patients with acute pancreatitis?
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Which sign is described as a bluish discoloration of the periumbilical area?
Which sign is described as a bluish discoloration of the periumbilical area?
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What is one of the primary goals of interprofessional care in patients with acute pancreatitis?
What is one of the primary goals of interprofessional care in patients with acute pancreatitis?
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What imaging modality is considered the best for diagnosing pancreatitis and related complications?
What imaging modality is considered the best for diagnosing pancreatitis and related complications?
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In managing hypotension due to acute pancreatitis, which treatment is administered?
In managing hypotension due to acute pancreatitis, which treatment is administered?
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Which of the following symptoms is less likely observed in a patient experiencing acute pancreatitis?
Which of the following symptoms is less likely observed in a patient experiencing acute pancreatitis?
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What may occur as a result of a pancreatic pseudocyst perforating?
What may occur as a result of a pancreatic pseudocyst perforating?
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What is a common non-surgical management option for pain relief in acute pancreatitis?
What is a common non-surgical management option for pain relief in acute pancreatitis?
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Which systemic complication can occur as a result of fluid shifts in acute pancreatitis?
Which systemic complication can occur as a result of fluid shifts in acute pancreatitis?
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What does NPO status aim to achieve in patients with acute pancreatitis?
What does NPO status aim to achieve in patients with acute pancreatitis?
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Which of the following treatments is typically reserved for patients who cannot tolerate enteral nutrition?
Which of the following treatments is typically reserved for patients who cannot tolerate enteral nutrition?
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What is the primary goal of monitoring vital signs in patients with acute pancreatitis?
What is the primary goal of monitoring vital signs in patients with acute pancreatitis?
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What signs may indicate hypocalcemia in a patient with acute pancreatitis?
What signs may indicate hypocalcemia in a patient with acute pancreatitis?
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What surgical procedure may be performed when acute pancreatitis is caused by gallstones?
What surgical procedure may be performed when acute pancreatitis is caused by gallstones?
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What is a significant complication of acute necrotizing pancreatitis?
What is a significant complication of acute necrotizing pancreatitis?
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Which of the following diets is recommended when oral intake is resumed for a patient recovering from acute pancreatitis?
Which of the following diets is recommended when oral intake is resumed for a patient recovering from acute pancreatitis?
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Why are vasoactive drugs such as dopamine used in treating hypotension related to pancreatitis?
Why are vasoactive drugs such as dopamine used in treating hypotension related to pancreatitis?
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What is the main reason for using NG suction in patients with acute pancreatitis?
What is the main reason for using NG suction in patients with acute pancreatitis?
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Which symptom is a clear indication of intolerance to oral foods in a patient with acute pancreatitis?
Which symptom is a clear indication of intolerance to oral foods in a patient with acute pancreatitis?
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In managing a patient with acute pancreatitis, what should be closely monitored due to the risk of metabolic instability?
In managing a patient with acute pancreatitis, what should be closely monitored due to the risk of metabolic instability?
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What is one of the overall goals in the planning stage for a patient with acute pancreatitis?
What is one of the overall goals in the planning stage for a patient with acute pancreatitis?
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Which nursing intervention is essential for a patient who has an NG tube?
Which nursing intervention is essential for a patient who has an NG tube?
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What approach may be taken if a patient shows signs of infection during the management of acute pancreatitis?
What approach may be taken if a patient shows signs of infection during the management of acute pancreatitis?
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Study Notes
Acute Pancreatitis Overview
- Acute pancreatitis is inflammation of the pancreas, causing autodigestion and severe pain.
- Inflammation ranges from mild edema to severe hemorrhagic necrosis.
Etiology and Pathophysiology
- Most common causes in the US are gallbladder disease (gallstones, more common in women) and chronic alcohol use (more common in men).
- Other causes include drug reactions, pancreatic cancer, and hypertriglyceridemia (serum levels >1000 mg/dL).
- Biliary sludge and microlithiasis (cholesterol crystals and calcium salts) can be present.
- The primary pathogenic mechanism is autodigestion.
- Injury to pancreatic cells or activation of enzymes within the pancreas (rather than the intestines) occurs. Often bile reflux into pancreatic ducts through an open or distended sphincter of Oddi (often from gallstones). This can lead to pancreatic ischemia.
- The mechanism of alcohol-induced pancreatitis is not fully understood, but thought to increase digestive enzyme production.
- Acute pancreatitis can be either mild (edematous or interstitial) or severe (necrotizing).
- Severe pancreatitis carries a high risk of pancreatic necrosis, organ failure, and septic complications, with an overall fatality rate of 9%.
Clinical Manifestations
- Main symptom is severe, deep, piercing abdominal pain (often sudden onset), in the left upper quadrant or mid-epigastric, radiating to the back.
- Worsened by eating, unrelieved by vomiting.
- May be accompanied by flushing, cyanosis, dyspnea, and positions involving trunk flexion to relieve the pain.
- Other symptoms include nausea, vomiting, low-grade fever, leukocytosis, hypotension, tachycardia, and jaundice.
- Abdominal tenderness with muscle guarding, decreased or absent bowel sounds, and paralytic ileus (marked abdominal distention) is common.
- Potential for lung involvement (crackles)
- Intravascular damage from trypsin can cause abdominal wall cyanosis or discoloration (greenish to yellow-brown).
- Bruising on flanks (Grey Turner spots) and periumbilical area (Cullen's sign). These are bloodstained exudate from the pancreas.
- Shock can occur from bleeding, toxemia, or hypovolemia from fluid shifts.
Complications
- Severity depends on the extent of pancreatic destruction.
- Can be life-threatening, but some patients recover completely, others recur, and some develop chronic pancreatitis.
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Local complications:
- Pseudocysts: Fluid/enzyme collection with a wall, causing abdominal pain and a palpable mass. Often resolve but can rupture.
- Treatment includes surgical or endoscopic/percutaneous drainage.
- Abscesses: Infection of a pseudocyst, causing upper abdominal pain, mass, high fever, and leukocytosis.
- Requires prompt surgical drainage.
- Pseudocysts: Fluid/enzyme collection with a wall, causing abdominal pain and a palpable mass. Often resolve but can rupture.
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Systemic complications:
- Cardiovascular and pulmonary issues (pleural effusion, atelectasis, pneumonia, ARDS) are common.
- Pulmonary complications are from exudate-containing pancreatic enzymes from the peritoneal cavity.
- Trypsin activation can increase risk for thrombi, emboli, and DIC.
- Tetany (hypocalcemia) can result from calcium and fatty acids combining during fat necrosis.
- Abdominal compartment syndrome from intra-abdominal hypertension and edema.
Diagnostic Studies
- Key tests are serum amylase and lipase (often elevated early, high for 24-72 hours). Lipase is a more specific marker.
- Other abnormalities include increased liver enzymes, triglycerides, glucose, and bilirubin; and decreased calcium.
- Imaging: Ultrasound, x-ray, and contrast-enhanced CT scan helpful to diagnose pancreatic issues. CT scan is best for complications like pseudocysts/abscesses. ERCP, EUS, MRCP, and angiography can also be used.
Interprofessional Care
- Goals: Pain relief, prevent/alleviate shock, reduce pancreatic secretions, correct fluid/electrolyte imbalances, prevent/treat infection.
- Initial treatment involves aggressive hydration, pain management, and minimizing pancreatic stimulation.
- Pain management through IV opioids and often an antispasmodic agent.
- Avoid anticholinergics if paralytic ileus is present.
- Reduce pancreatic secretions: NPO, NG suction, drugs to suppress gastric acid.
- Prevent infections, especially in severe necrotizing pancreatitis, with close monitoring and antibiotic therapy if infection occurs.
Treatments (cont'd)
- For gallstone-related pancreatitis : ERCP with sphincterotomy and potentially later cholecystectomy.
- Surgical or endoscopic drainage may be needed for necrotic fluid collections or pseudocysts.
Drug Therapy
- Many drugs are used but no cure exists.
Nutrition Therapy
- Initially, patients are NPO to reduce pancreatic stimulation.
- Enteral nutrition (EN) is started based on severity; parenteral nutrition (PN) is used for those who can't tolerate EN.
- Monitor blood triglyceride levels if IV lipids are administered.
- Transition to small, frequent, high-carbohydrate meals as tolerated, avoiding crash diets.
Nursing Management
- Key assessments: subjective and objective data based on complications and potential issues (detailed in Table 48.21).
- Clinical problems: pain, fluid imbalance, electrolyte imbalance, malnutrition.
- Planning: goals include pain relief, normal fluid/electrolyte balance, minimal complications, and no recurrence.
- Implementation: health promotion that focuses on assessment of risk factors and early intervention; acute care involving vital sign monitoring, assessing fluid/electrolyte balance, addressing potential respiratory complications for severe pancreatitis, and treating complications like hypocalcemia.
- Observation for infections and preventing them including maintaining oral/nasal care (especially when taking anticholinergics).
Ambulatory Care
- Home care, physical therapy, continued infection prevention and complication detection.
- Counseling on abstinence from alcohol and smoking cessation (nicotine stimulates pancreas).
- Patient and caregiver education on the treatment plan, importance of medications, and a low-fat diet with high carbohydrates.
- Recognizing and reporting signs of infection, diabetes, or steatorrhea, and any exogenous enzyme supplementation needs.
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Description
This quiz covers the essential aspects of acute pancreatitis, including its etiology, pathophysiology, and common causes. Understand the mechanisms involved in pancreatic inflammation, from gallbladder disease to alcohol use. Learn about the effects of autodigestion and injury to pancreatic cells.