Acute Leukemias in Hematology

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Questions and Answers

What is the minimum percentage of blasts in the bone marrow required for the diagnosis of AML according to the WHO?

  • 15%
  • 20% (correct)
  • 10%
  • 25%

What is the characteristic of chromatin in Myeloblasts?

  • Coarse with prominent nucleoli
  • Uniform and fine (correct)
  • Coarse
  • Variable

Which of the following is a characteristic of Promyelocytes?

  • Hypogranular
  • No nucleoli
  • Hyper-granular (correct)
  • No Auer rods

What is the significance of t(15;17) translocation in AML?

<p>Good prognosis (C)</p> Signup and view all the answers

What is the typical age range for the onset of AML?

<p>65 years or older (B)</p> Signup and view all the answers

What is the primary consequence of bone marrow failure in patients with acute leukemias?

<p>Suppression of normal hematopoiesis, leading to anemia, neutropenia, and thrombocytopenia (D)</p> Signup and view all the answers

What is a common characteristic of acute leukemias in terms of cellular differentiation?

<p>Block in cellular differentiation in the bone marrow (A)</p> Signup and view all the answers

Which of the following environmental exposures is NOT associated with an increased risk of hematopoietic malignancies?

<p>Vitamin C supplementation (A)</p> Signup and view all the answers

What is the primary difference between acute and chronic leukemias in terms of treatment outcomes?

<p>Acute leukemias are more aggressive, but younger patients are ultimately cured (C)</p> Signup and view all the answers

What is the consequence of chemotherapy-induced DNA damage in hematopoietic cells?

<p>Therapy-related leukemias (A)</p> Signup and view all the answers

Flashcards

AML Diagnostic Criteria (WHO)

20% or greater blasts in the bone marrow.

Myeloblast Chromatin

Uniform and fine.

Promyelocyte Characteristic

Hyper-granular.

t(15;17) Significance in AML

Associated with a good prognosis.

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Consequence of Bone Marrow Failure

Suppression of normal hematopoiesis, leading to anemia, neutropenia, and thrombocytopenia.

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Characteristic of Acute Leukemias

Block in cellular differentiation in the bone marrow.

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Difference Between Acute & Chronic Leukemias (Treatment)

Acute leukemias are more aggressive, but younger patients are ultimately cured.

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Chemotherapy-Induced DNA Damage Consequence

Therapy-related leukemias.

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