15 Questions
What is the peak incidence age for acute lymphoblastic leukemia?
2-5 years old
Which classification scheme is based on morphologic examination along with cytochemical stains to distinguish lymphoblasts from myoblasts?
French-American-British (FAB)
What is the widely accepted theory for the development of therapy-related leukemias?
Stepwise progression of mutations
What is the known cause of hematopoietic malignancies mentioned in the text?
Radiation and benzene
What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?
At least 20%
What is the widely accepted theory for the development of therapy-related leukemias?
Stepwise progression of mutations
How is the French-American-British (FAB) classification scheme based?
Morphologic examination and cytochemical stains
What is the peak incidence age for acute lymphoblastic leukemia?
2-5 years old
What are the common symptoms of B cell acute lymphoblastic leukemia?
Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly
What is the minimum percentage of blasts required in the bone marrow for the diagnosis of acute lymphoblastic leukemia according to WHO classification?
At least 20%
What is the widely accepted theory for the development of therapy-related leukemias?
Stepwise progression of mutations 'multiple hits'
What is the peak incidence age for acute lymphoblastic leukemia?
2-5 years old
What is the known cause of hematopoietic malignancies mentioned in the text?
Radiation exposure
What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?
At least 20%
What are the common symptoms of B cell acute lymphoblastic leukemia?
Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly
Test your knowledge of acute leukemia with this quiz. Learn about the rapid proliferation of lymphoid or myeloid progenitor cells in the bone marrow and the factors contributing to the development of malignancy. Explore the known causes, familial predisposition, and therapy-related leukemias.
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