Acute Leukemia
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Questions and Answers

What is the peak incidence age for acute lymphoblastic leukemia?

  • 11-15 years old
  • 2-5 years old (correct)
  • 6-10 years old
  • 16-20 years old

    • Which classification scheme is based on morphologic examination along with cytochemical stains to distinguish lymphoblasts from myoblasts?

  • International Prognostic Scoring System (IPSS)
  • French-American-British (FAB) (correct)
  • World Health Organization (WHO)
  • European LeukemiaNet (ELN)

    • What is the widely accepted theory for the development of therapy-related leukemias?

  • Random occurrence unrelated to treatment
  • Stepwise progression of mutations (correct)
  • Rapid onset due to genetic predisposition
  • Direct impact of chemotherapy on healthy cells

    • What is the known cause of hematopoietic malignancies mentioned in the text?

    <p>Radiation and benzene</p> Signup and view all the answers

    What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

    <p>At least 20%</p> Signup and view all the answers

    What is the widely accepted theory for the development of therapy-related leukemias?

    <p>Stepwise progression of mutations</p> Signup and view all the answers

    How is the French-American-British (FAB) classification scheme based?

    <p>Morphologic examination and cytochemical stains</p> Signup and view all the answers

    What is the peak incidence age for acute lymphoblastic leukemia?

    <p>2-5 years old</p> Signup and view all the answers

    What are the common symptoms of B cell acute lymphoblastic leukemia?

    <p>Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly</p> Signup and view all the answers

    What is the minimum percentage of blasts required in the bone marrow for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

    <p>At least 20%</p> Signup and view all the answers

    What is the widely accepted theory for the development of therapy-related leukemias?

    <p>Stepwise progression of mutations 'multiple hits'</p> Signup and view all the answers

    What is the peak incidence age for acute lymphoblastic leukemia?

    <p>2-5 years old</p> Signup and view all the answers

    What is the known cause of hematopoietic malignancies mentioned in the text?

    <p>Radiation exposure</p> Signup and view all the answers

    What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

    <p>At least 20%</p> Signup and view all the answers

    What are the common symptoms of B cell acute lymphoblastic leukemia?

    <p>Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly</p> Signup and view all the answers

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