Acute Leukemia
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Questions and Answers

What is the peak incidence age for acute lymphoblastic leukemia?

  • 11-15 years old
  • 2-5 years old (correct)
  • 6-10 years old
  • 16-20 years old

Which classification scheme is based on morphologic examination along with cytochemical stains to distinguish lymphoblasts from myoblasts?

  • International Prognostic Scoring System (IPSS)
  • French-American-British (FAB) (correct)
  • World Health Organization (WHO)
  • European LeukemiaNet (ELN)

What is the widely accepted theory for the development of therapy-related leukemias?

  • Random occurrence unrelated to treatment
  • Stepwise progression of mutations (correct)
  • Rapid onset due to genetic predisposition
  • Direct impact of chemotherapy on healthy cells

What is the known cause of hematopoietic malignancies mentioned in the text?

<p>Radiation and benzene (D)</p> Signup and view all the answers

What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

<p>At least 20% (A)</p> Signup and view all the answers

What is the widely accepted theory for the development of therapy-related leukemias?

<p>Stepwise progression of mutations (C)</p> Signup and view all the answers

How is the French-American-British (FAB) classification scheme based?

<p>Morphologic examination and cytochemical stains (C)</p> Signup and view all the answers

What is the peak incidence age for acute lymphoblastic leukemia?

<p>2-5 years old (C)</p> Signup and view all the answers

What are the common symptoms of B cell acute lymphoblastic leukemia?

<p>Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly (A)</p> Signup and view all the answers

What is the minimum percentage of blasts required in the bone marrow for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

<p>At least 20% (D)</p> Signup and view all the answers

What is the widely accepted theory for the development of therapy-related leukemias?

<p>Stepwise progression of mutations 'multiple hits' (D)</p> Signup and view all the answers

What is the peak incidence age for acute lymphoblastic leukemia?

<p>2-5 years old (B)</p> Signup and view all the answers

What is the known cause of hematopoietic malignancies mentioned in the text?

<p>Radiation exposure (C)</p> Signup and view all the answers

What percentage of blasts in the bone marrow is required for the diagnosis of acute lymphoblastic leukemia according to WHO classification?

<p>At least 20% (B)</p> Signup and view all the answers

What are the common symptoms of B cell acute lymphoblastic leukemia?

<p>Fatigue, fever, mucocutaneous bleeding, lymphadenopathy, and hepatosplenomegaly (A)</p> Signup and view all the answers
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