Acute Inflammation Quiz
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Questions and Answers

Which type of acute inflammation is characterized by pus formation?

  • Non-suppurative inflammation
  • Serous inflammation
  • Catarrhal inflammation
  • Acute suppurative inflammation (correct)
  • Which microorganism is the most common cause of abscess and carbuncle formation?

  • Staphylococcus aureus (correct)
  • Bacillus coli
  • Gonococcus
  • Pneumococcus
  • What is a key complication of acute suppurative inflammation?

  • Autoimmune response
  • Localized infection
  • Nutritional deficiency
  • Septicemia and toxemia (correct)
  • Which of the following describes a subcutaneous abscess?

    <p>Localized suppurative inflammation with pus in a cavity (A)</p> Signup and view all the answers

    Which category does catarrhal inflammation belong to?

    <p>Non-suppurative inflammation (D)</p> Signup and view all the answers

    What is the first step of the inflammatory cellular exudate formation?

    <p>Margination (A)</p> Signup and view all the answers

    Which of the following accurately describes phagocytosis?

    <p>Engulfment of particulate material by phagocytic cells (A)</p> Signup and view all the answers

    What role do chemotactic factors play in inflammation?

    <p>Promote migration of phagocytic cells toward irritants (A)</p> Signup and view all the answers

    Which of these is NOT a step in the phagocytosis process?

    <p>Activation of T-cells (B)</p> Signup and view all the answers

    What is the result of a phagosome fusing with a lysosome?

    <p>Formation of a phagolysosome (C)</p> Signup and view all the answers

    Which of the following is a known chemotactic factor?

    <p>Leukotriene B4 (A)</p> Signup and view all the answers

    What substance is primarily involved in opsonization during phagocytosis?

    <p>Opsonins (B)</p> Signup and view all the answers

    What is the primary mechanism of oxygen dependent killing in bacteria?

    <p>Production of reactive oxygen species (ROS) (D)</p> Signup and view all the answers

    Which local sign of acute inflammation is primarily caused by fluid exudate?

    <p>Swelling (A)</p> Signup and view all the answers

    Which systemic effect is associated with acute inflammation?

    <p>Leucocytosis (D)</p> Signup and view all the answers

    What happens during the resolution phase of acute inflammation?

    <p>Morphological changes in cells are reversed (D)</p> Signup and view all the answers

    What is meant by 'chronicity' in relation to acute inflammation?

    <p>Persistence of the irritant despite immune response (D)</p> Signup and view all the answers

    Which cell types are primarily involved in an acute inflammatory reaction?

    <p>Macrophages and neutrophils (D)</p> Signup and view all the answers

    When does healing by fibrosis occur?

    <p>Following permanent cell injury (D)</p> Signup and view all the answers

    What causes the hotness and redness observed in acute inflammation?

    <p>Vasodilatation and hyperemia (C)</p> Signup and view all the answers

    What type of tissue response occurs in the regression and healing phase after an irritant is overcome?

    <p>Regeneration with replacement by healthy cells (D)</p> Signup and view all the answers

    Which component is NOT typically associated with the acute inflammatory reaction?

    <p>Chronic inflammatory cells (D)</p> Signup and view all the answers

    Flashcards

    Inflammatory cellular exudate

    Passage of leukocytes from the bloodstream into the tissue surrounding an inflamed area.

    Margination

    Accumulation of leukocytes along the inner surface of blood vessels in an inflamed area.

    Rolling, adhesion, and transmigration

    Process by which leukocytes roll and adhere to the inner surface of blood vessels and migrate into the inflamed tissue.

    Chemotaxis

    Movement of leukocytes towards the site of inflammation guided by chemical signals released by damaged cells.

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    Phagocytosis

    The engulfment of particulate matter (e.g., tissue debris, bacteria) by phagocytic cells, mainly neutrophils and macrophages.

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    Opsonins (e.g., IgG and C3b)

    Substances that coat particulate matter to enhance its recognition and engulfment by phagocytic cells.

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    Killing and degradation of ingested material

    Killing and breaking down of ingested materials within phagocytic cells using oxygen-dependent or oxygen-independent mechanisms.

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    Oxygen-dependent killing

    The process by which white blood cells, like neutrophils, use reactive oxygen species (ROS) to kill bacteria.

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    Oxygen-independent killing

    Killing of bacteria by white blood cells through the action of enzymes and other substances found in their granules.

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    Opsonin

    A substance that enhances the ability of phagocytes to engulf and kill bacteria.

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    Phagolysosome formation

    The fusion of a phagosome (containing a bacterium) with a lysosome (containing digestive enzymes), forming a single compartment that's like a cellular prison. This triggers the destruction of the bacteria.

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    Hyperemia

    The increase in blood flow to a damaged area, causing redness and heat.

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    What is an abscess?

    A localized collection of pus, a thick, yellowish fluid composed of dead white blood cells, bacteria, and tissue debris.

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    What is acute suppurative inflammation?

    An inflammation characterized by pus formation, caused by pyogenic microorganisms such as Staphylococcus aureus, Pneumococcus, Gonococcus, and Bacillus coli.

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    Which bacteria is the most common cause of abscesses?

    A common cause of abscesses, carbuncles, and other skin infections. It produces coagulase, an enzyme that helps form a fibrin clot and localizes the infection.

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    What is a carbuncle?

    A severe form of skin infection often involving multiple hair follicles, characterized by redness, swelling, pain, and the formation of multiple abscesses.

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    What is diffuse inflammation?

    Inflammation that spreads throughout the tissue rather than being confined to a specific area.

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    Study Notes

    Inflammation-2

    • Presentation by Dr. Gehan Abdelmenam
    • Topics covered include the inflammatory cellular exudate, phagocytosis, acute inflammation, fate of acute inflammation, types of acute inflammation, and abscesses.

    Intended Learning Objectives

    • Recall the definition and mechanism of formation of inflammatory cellular exudate.
    • Define phagocytosis and its steps.
    • List systemic effects and local signs of acute inflammation.
    • Describe the fate and types of acute inflammation.
    • Recall the definition, sites, and complications of an abscess.

    Inflammatory Cellular Exudate

    • Definition: The passage of leukocytes to the interstitial space of the inflamed area.
    • Steps:
      • Margination: Accumulation of leukocytes along the endothelial surface.
      • Rolling: Leukocytes loosely adhere to the endothelium and roll along it.
      • Adhesion: Firm adhesion of leukocytes to the endothelium.
      • Transmigration (Diapedesis): Leukocytes migrate through the endothelial walls.
      • Chemotaxis: Movement of leukocytes toward the irritant.

    Phagocytosis

    • Definition: The process of engulfing and destroying particulate material, such as tissue debris, bacteria, etc., by phagocytic cells (neutrophils and macrophages).
    • Steps:
      • Recognition and Attachment: Receptors on leukocytes recognize the particle to be ingested and attach to it by opsonization (coating of particle with opsonins like IgG and C3b).
      • Engulfment: The phagocytic cell sends out pseudopods to surround and engulf the particle, forming a phagosome.
      • Killing and Degradation: The phagosome fuses with lysosomes to form a phagolysosome and the lysosomal contents kill and degrade the ingested material. Mechanisms include oxygen-dependent (ROS) and oxygen-independent (hydrolytic substances) pathways.

    Local Signs of Acute Inflammation

    • Hotness: Due to vasodilation and hyperemia.
    • Redness: Due to vasodilation and hyperemia.
    • Swelling: Due to fluid exudate.
    • Pain: Caused by irritation of nerve endings by toxins and pressure of inflammatory exudate on sensory nerves, along with the release of prostaglandin E2 and bradykinin.
    • Loss of function: Due to tissue destruction or to avoid pain.

    Systemic Effects of Acute Inflammation

    • Fever (Pyrexia): Elevated body temperature.
    • Anorexia: Loss of appetite.
    • Headache: Pain in the head.
    • Malaise: Feeling of discomfort or illness.
    • Leucocytosis: Increased white blood cell count.

    Fate of Acute Inflammation

    • Resolution: The usual course of acute inflammation, where no tissue loss occurs, and the inflamed area returns to normal as products of inflammation are rapidly removed and cells return to normal.
    • Regression and Healing: The body overcomes the irritant, necrotic tissue is removed by macrophages, and healing occurs through regeneration (replacement by the same cell type) or fibrosis (scarring) depending on the cell type.
    • Progression and Spread: Inflammation spreads through blood, lymph, and direct spread of bacteria, causing conditions like septicemia, toxemia.
    • Chronicity: The causative irritant is not completely overcome, leading to persistent inflammation.

    Acute Inflammatory Reaction

    • Consists of:
      • Dilated blood vessels
      • Acute inflammatory cells (neutrophils, macrophages)
      • Exudate

    Types of Acute Inflammation

    • Suppurative (pus-forming): localized (boil, abscess, carbuncle), and diffuse (cellulitis, appendicitis).
    • Non-suppurative (non-pus-forming): catarrhal, pseudomembranous, serous, fibrinous, sero-fibrinous, hemorrhagic, necrotizing, allergic.

    Acute Suppurative Inflammation (Pyogenic/Septic)

    • Definition: Severe acute inflammation characterized by pus formation.
    • Causes: Pyogenic microorganisms (like Staphylococcus aureus, pneumococcus, gonococcus, bacillus coli)

    Abscess

    • Definition: A localized collection of pus in a tissue space.
    • Etiology: Often caused by Staphylococcus aureus, which produces coagulase to localize the infection.
    • Sites: Common in subcutaneous tissues, but any organ can be affected (e.g., lungs, brain, liver, breast).
    • Complications: Blood spread (septicemia, toxemia), chronicity, lymphangitis, lymphadenitis.

    Subcutaneous abscess

    • Subtype of abscess.

    This is a summary based on the provided images. Please note that some terms may have varying nuances depending on the specific context.

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    Description

    Test your knowledge on acute inflammation, including pus formation, common microorganisms involved, and the steps of the inflammatory response. This quiz will cover various aspects, such as abscess formation, complications, and the process of phagocytosis. Perfect for students of medicine or healthcare.

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