Acute Inflammation Lecture: Vascular and Cellular Events

During acute inflammation, vasodilation is induced by the action of several mediators, notably histamine.

The result of increased blood flow during acute inflammation is the cause of heat and redness (erythema).

Leukocytes, principally neutrophils, accumulate along the endothelial lining in a process known as margination.

During acute inflammation, RBCs become more effectively concentrated due to the exudation of protein-rich fluid into the extravascular tissue.

Brief arteriolar vasoconstriction is followed by vasodilation during acute inflammation.

Increased vascular permeability in acute inflammation is primarily due to the contraction and retraction of endothelial cells.

Endothelial injury in severe injuries, such as thermal burns, may lead to increased vascular permeability.

Histamine, kinins, and other mediators can induce increased vascular permeability by producing gaps between endothelial cells.

Increased vascular permeability in early inflammation is primarily due to decreased intravascular hydrostatic pressure.

Lymphatic vessels and lymph nodes are not involved in acute inflammation and do not show redness or swelling.