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Lecture 5

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What is inflammation a response to?

Necrotic cells and tissues resulting from the original insult

What characterizes acute inflammation?

Predominantly neutrophilic accumulation, fluid & plasma protein exudation

What is the duration of chronic inflammation?

Days to years

What is the fifth classic cardinal sign of inflammation?

<p>Functio lease (Loss of function)</p> Signup and view all the answers

What is the result of hyperemia?

<p>Increased blood flow to the injured area</p> Signup and view all the answers

What happens as blood flow increases in capillaries?

<p>Capillary hydrostatic pressure rises</p> Signup and view all the answers

What is the primary reason for fluid leading to pain in inflammation?

<p>Increased permeability at postcapillary venules</p> Signup and view all the answers

What is the result of blood volume decreasing and becoming viscous?

<p>Aggregation of RBCs</p> Signup and view all the answers

Which of the following is an example of a physical agent that can cause inflammation?

<p>Thermal injury</p> Signup and view all the answers

What is the primary function of WBCs in inflammation?

<p>To clear the invaders and start digesting the necrotic tissue</p> Signup and view all the answers

What is the term for inflammatory diseases caused by immune reactions or hypersensitivity reactions?

<p>Immune-mediated inflammatory diseases</p> Signup and view all the answers

What is the result of increased vascular permeability in acute inflammation?

<p>Extravascular leakage of plasma proteins</p> Signup and view all the answers

What is the primary cell involved in acute inflammation?

<p>Neutrophil</p> Signup and view all the answers

What is the term for the accumulation of fluid in the extra-vascular space?

<p>Edema</p> Signup and view all the answers

What is the main difference between transudate and exudate?

<p>Exudate is rich in proteins, while transudate has little proteins</p> Signup and view all the answers

What is the primary cause of transudate formation?

<p>Increased hydrostatic pressure in the capillaries</p> Signup and view all the answers

What is the location where endothelial cell contraction is most pronounced during acute inflammation?

<p>Post-capillary venules</p> Signup and view all the answers

What is the result of increased osmotic pressure in the interstitial tissues?

<p>Outflow of water and ions into the extravascular tissues</p> Signup and view all the answers

What is the main characteristic of ultrafiltrate of plasma?

<p>Low protein content</p> Signup and view all the answers

What is the primary mechanism of increasing permeability of small vessels during inflammation due to chemical mediators?

<p>Formation of gaps between endothelial cells</p> Signup and view all the answers

What is the response of lymphatics during inflammation?

<p>Lymph flow is increased, and drains edema fluid</p> Signup and view all the answers

What is the sequence of events in the recruitment of leukocytes during inflammation?

<p>Margination, rolling, firm adhesions, and pavementing</p> Signup and view all the answers

What is the result of increased vascular permeability during inflammation?

<p>Increased interstitial osmotic pressure</p> Signup and view all the answers

What is the characteristic of exudate?

<p>High protein content and specific gravity &gt;1.020</p> Signup and view all the answers

What is the primary mechanism of increasing permeability of small vessels during inflammation?

<p>All of the above</p> Signup and view all the answers

What is the effect of histamine on endothelial cells during inflammation?

<p>Formation of gaps between endothelial cells</p> Signup and view all the answers

What is the primary function of lymphatics during inflammation?

<p>Draining edema fluid</p> Signup and view all the answers

What is the sequence of events in the recruitment of leukocytes during inflammation?

<p>Margination, rolling, and firm adhesions</p> Signup and view all the answers

What is the characteristic of ultrafiltrate of plasma?

<p>Low protein content</p> Signup and view all the answers

What is the result of increased vascular permeability during inflammation?

<p>Formation of exudate</p> Signup and view all the answers

What is the primary event in the increased permeability of small vessels during inflammation?

<p>Formation of gaps between endothelial cells</p> Signup and view all the answers

What is the result of increased interstitial osmotic pressure?

<p>Formation of exudate</p> Signup and view all the answers

What is the primary function of leukocyte activation during inflammation?

<p>To fight off pathogens</p> Signup and view all the answers

What is the characteristic of exudate?

<p>High protein content</p> Signup and view all the answers

What is the primary reason for the increased lymph flow during inflammation?

<p>To drain edema fluid</p> Signup and view all the answers

Which of the following mechanisms is responsible for the increased permeability of small vessels during inflammation due to the effect of chemical mediators?

<p>Formation of gaps between endothelial cells</p> Signup and view all the answers

What is the characteristic of exudate that distinguishes it from ultrafiltrate of plasma?

<p>High protein content and specific gravity &gt;1.020</p> Signup and view all the answers

What is the sequence of events in the recruitment of leukocytes to the extravascular space during inflammation?

<p>Margination, rolling, firm adhesions, and pavementing</p> Signup and view all the answers

What is the primary function of leukocyte activation during inflammation?

<p>To phagocytose foreign particles and bacteria</p> Signup and view all the answers

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