Podcast
Questions and Answers
What is the main differentiating factor between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
What is the main differentiating factor between Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
- Presence of pustules
- Severity of skin discoloration
- Extent of epidermal detachment (correct)
- Involvement of hair follicles
Which factor contributes mainly to mortality in both Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
Which factor contributes mainly to mortality in both Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
- Liver dysfunction
- Respiratory complications and sepsis (correct)
- Neurological damage
- Renal failure
What is the SCORTEN used for in the context of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
What is the SCORTEN used for in the context of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
- To predict mortality (correct)
- To diagnose the condition
- To select appropriate antibiotics
- To determine the cause
What type of disorder is Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) considered to be?
What type of disorder is Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) considered to be?
Which type of cells infiltrate mainly in the blister fluid and epidermis in the early stages of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
Which type of cells infiltrate mainly in the blister fluid and epidermis in the early stages of Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN)?
What newly proposed prognosis score has been introduced for Toxic Epidermal Necrolysis (TEN)?
What newly proposed prognosis score has been introduced for Toxic Epidermal Necrolysis (TEN)?
What is the mechanism of Acute Generalized Exanthematous Pustulosis (AGEP)?
What is the mechanism of Acute Generalized Exanthematous Pustulosis (AGEP)?
Which of the following is NOT typically reported in association with AGEP?
Which of the following is NOT typically reported in association with AGEP?
What is the approximate mortality rate associated with AGEP?
What is the approximate mortality rate associated with AGEP?
What clinical characteristic is NOT typical of Acute Generalized Exanthematous Pustulosis?
What clinical characteristic is NOT typical of Acute Generalized Exanthematous Pustulosis?
What histological feature is characteristic of AGEP?
What histological feature is characteristic of AGEP?
What percentage of patients with AGEP experience mild and nonerosive mucosal involvement?
What percentage of patients with AGEP experience mild and nonerosive mucosal involvement?
Which pathway is NOT involved in inducing apoptosis of keratinocytes in SJS/TEN?
Which pathway is NOT involved in inducing apoptosis of keratinocytes in SJS/TEN?
What is the main role of granulysin in the cytotoxic effect of SJS/TEN?
What is the main role of granulysin in the cytotoxic effect of SJS/TEN?
What distinguishes the skin lesions of TEN patients from those with maculopapular drug reactions?
What distinguishes the skin lesions of TEN patients from those with maculopapular drug reactions?
What is a key feature that distinguishes apoptosis from necroptosis?
What is a key feature that distinguishes apoptosis from necroptosis?
How do cytotoxic CD8+ T cells induce apoptosis in SJS/TEN?
How do cytotoxic CD8+ T cells induce apoptosis in SJS/TEN?
What is the significant clinical diagnostic clue in both SJS and TEN?
What is the significant clinical diagnostic clue in both SJS and TEN?
What is the main reason to avoid the sulfonamide derivatives in the treatment of skin conditions?
What is the main reason to avoid the sulfonamide derivatives in the treatment of skin conditions?
According to the UK guidelines for the management of SJS/TEN, what is prioritized over systemic treatment?
According to the UK guidelines for the management of SJS/TEN, what is prioritized over systemic treatment?
What is recommended as a first-line treatment in the Japanese guidelines for SJS/TEN?
What is recommended as a first-line treatment in the Japanese guidelines for SJS/TEN?
Which phase of DIHS/DRESS syndrome may immunosuppressive treatments be considered suitable?
Which phase of DIHS/DRESS syndrome may immunosuppressive treatments be considered suitable?
What skin manifestation is characteristic of DIHS/DRESS syndrome?
What skin manifestation is characteristic of DIHS/DRESS syndrome?
What is a common feature of the drugs known to cause DIHS/DRESS syndrome?
What is a common feature of the drugs known to cause DIHS/DRESS syndrome?
What is the most common cause of Erythema Multiforme?
What is the most common cause of Erythema Multiforme?
Which biomarkers have been established but are not yet used in the clinical setting for predicting severe forms of SJS/TEN?
Which biomarkers have been established but are not yet used in the clinical setting for predicting severe forms of SJS/TEN?
What is a distinguishing feature that helps differentiate Erythema Multiforme from SJS/TEN?
What is a distinguishing feature that helps differentiate Erythema Multiforme from SJS/TEN?
Which area is most commonly affected by mucosal involvement in SJS/TEN?
Which area is most commonly affected by mucosal involvement in SJS/TEN?
What is typically seen in Erythema Multiforme lesions but only slightly present in SJS/TEN lesions?
What is typically seen in Erythema Multiforme lesions but only slightly present in SJS/TEN lesions?
What is recommended as part of the treatment for SJS and TEN to decrease mortality rate despite some mucocutaneous progression?
What is recommended as part of the treatment for SJS and TEN to decrease mortality rate despite some mucocutaneous progression?
What is a hallmark of Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia and systemic symptoms (DRESS)?
What is a hallmark of Drug-induced hypersensitivity syndrome (DIHS)/Drug reaction with eosinophilia and systemic symptoms (DRESS)?
Which internal organ is the most frequently involved in Drug-induced hypersensitivity syndrome (DIHS)/DRESS?
Which internal organ is the most frequently involved in Drug-induced hypersensitivity syndrome (DIHS)/DRESS?
What is a rare manifestation of DIHS/DRESS?
What is a rare manifestation of DIHS/DRESS?
Which virus reactivation has been demonstrated to occur during DIHS/DRESS?
Which virus reactivation has been demonstrated to occur during DIHS/DRESS?
What is a potential fatal complication of CMV reactivation in DIHS/DRESS?
What is a potential fatal complication of CMV reactivation in DIHS/DRESS?
What are frequently encountered blood abnormalities in DIHS/DRESS?
What are frequently encountered blood abnormalities in DIHS/DRESS?
How soon after onset can reactivation of CMV occur in DIHS/DRESS?
How soon after onset can reactivation of CMV occur in DIHS/DRESS?
What is the mortality rate associated with DRESS syndrome?
What is the mortality rate associated with DRESS syndrome?
What is crucial for the treatment of DIHS/DRESS according to the text?
What is crucial for the treatment of DIHS/DRESS according to the text?
What did a Japanese group propose in 2019 for the treatment of DIHS/DRESS?
What did a Japanese group propose in 2019 for the treatment of DIHS/DRESS?
