Acute Coronary Syndrome (ACS)
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Questions and Answers

In the context of acute myocardial infarction treatment, why are ACE inhibitors particularly beneficial for patients who have a history of heart failure?

  • They prevent adverse ventricular remodeling, reducing the progression of heart failure. (correct)
  • They directly dissolve existing blood clots in the coronary arteries.
  • They enhance myocardial oxygen supply by increasing systemic vascular resistance.
  • They immediately reduce chest pain by directly acting on cardiac pain receptors.

How do beta-blockers help in managing a myocardial infarction?

  • By promoting platelet aggregation to stabilize potential thrombi
  • By increasing myocardial contractility to enhance cardiac output
  • By directly dilating coronary arteries, improving blood flow to the heart muscle
  • By decreasing myocardial oxygen demand, reducing the workload on the heart (correct)

Why is aspirin administered during the initial management of a myocardial infarction?

  • To stabilize blood pressure by reducing systemic vascular resistance.
  • To decrease platelet adherence, limiting clot formation. (correct)
  • To induce vasodilation of the coronary arteries, enhancing blood flow
  • To directly reduce myocardial oxygen consumption, alleviating ischemia.

In what specific clinical scenario is oxygen therapy most appropriately administered to a patient experiencing a myocardial infarction?

<p>When the patient's oxygen saturation levels indicate hypoxia. (B)</p> Signup and view all the answers

What is the primary mechanism by which nitrates alleviate the symptoms of a myocardial infarction?

<p>By dilating systemic vasculature, they reduce preload and afterload (C)</p> Signup and view all the answers

Which of the following scenarios would MOST strongly suggest a diagnosis of unstable angina rather than stable angina?

<p>Chest pain that has increased in frequency, duration, and intensity over the past week. (B)</p> Signup and view all the answers

Why is the presence of ST-segment elevation on an ECG a critical indicator in the diagnosis of ACS?

<p>It confirms complete and persistent occlusion of a coronary artery, with significant damage to the heart muscle. (B)</p> Signup and view all the answers

In the context of acute coronary syndrome (ACS), which of the following is the PRIMARY mechanism by which atherosclerotic plaques contribute to the development of myocardial ischemia?

<p>Plaque rupture or erosion leads to thrombus formation, obstructing coronary blood flow. (C)</p> Signup and view all the answers

A patient presents with chest pain and shortness of breath. Which piece of information would MOST strongly suggest that the patient's symptoms are due to ACS rather than gastroesophageal reflux disease (GERD)?

<p>The patient experiences pain radiating to the left arm, accompanied by diaphoresis. (B)</p> Signup and view all the answers

Which of the following statements BEST describes the role of cardiac biomarkers, such as troponin, in the diagnosis of NSTEMI?

<p>Cardiac biomarkers confirm the presence of myocardial damage, distinguishing NSTEMI from unstable angina. (A)</p> Signup and view all the answers

A 60-year-old male presents to the emergency department complaining of chest pain that he describes as a burning sensation in his mid-chest that started after a large meal. He denies any radiation of the pain, shortness of breath, or diaphoresis. How should clinicians differentiate between GERD AND ACS?

<p>Check ECG and cardiac enzymes. (C)</p> Signup and view all the answers

A patient is suspected of having ACS, but their initial ECG shows no ST-segment elevation. In what timeframe should serial cardiac biomarkers be measured to assess for myocardial damage?

<p>Every 6-8 hours during the first 24 hours. (D)</p> Signup and view all the answers

Which of the following is LEAST likely to be a symptom of ACS in women?

<p>Typical substernal chest pain. (D)</p> Signup and view all the answers

Flashcards

Aspirin in MI treatment

Medications used to reduce platelet adherence, limiting clot formation.

Nitrates in MI treatment

Medications that dilate blood vessels, increasing blood flow.

Reperfusion Therapy

A therapy focused on re-establishing blood flow to the heart muscle.

Reperfusion Methods

Procedure to restore blood flow, such as PCI or thrombolytic therapy.

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ACE inhibitors

Medications that lower blood pressure and reduce resistance in blood vessels.

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Myocardial Ischemia

Reduced blood flow to the heart muscle, often due to blood clots or plaque.

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Acute Coronary Syndrome (ACS)

Umbrella term for conditions like unstable angina, NSTEMI, and STEMI, all involving reduced blood flow to the heart.

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Unstable Angina

Chest pain that is new, worsening, or occurs at rest; no permanent heart damage.

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Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)

Heart attack with elevated cardiac biomarkers but no ST-segment elevation on ECG.

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ST-Segment Elevation Myocardial Infarction (STEMI)

Severe heart attack with complete blockage of a coronary artery and ST-segment elevation on ECG.

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Levine's Sign

Clenched fist over the sternum indicating chest discomfort.

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Diaphoresis (in ACS)

Profuse sweating, a common symptom during ACS.

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Fatigue (in ACS)

Feeling tired and weak, can be a sign of inadequate cardiac function.

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Study Notes

  • Myocardial ischemia is typically caused by a blood clot (coronary thrombosis) or atherosclerotic plaque.

Acute Coronary Syndrome (ACS)

  • ACS is a medical emergency comprising unstable angina, non-ST-segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial infarction (STEMI).
  • ACS is often caused by the rupture or erosion of plaque in a coronary artery, leading to blood clot formation that blocks blood flow to the heart muscle.

Unstable Angina

  • Unstable angina is a type of ACS without permanent heart muscle damage.
  • Symptoms include severe chest pain, discomfort that is more prolonged or frequent than typical angina, occurring at rest or with minimal exertion.

Non-ST-Segment Elevation Myocardial Infarction (NSTEMI)

  • NSTEMI involves myocardial damage, indicated by the release of cardiac biomarkers like troponin into the bloodstream.
  • ECG shows no significant ST-segment elevation, and coronary artery blockage may be partial or transient.

ST-Segment Elevation Myocardial Infarction (STEMI)

  • STEMI is a severe heart attack with complete and persistent coronary artery blockage, resulting in significant heart muscle damage.
  • ECG typically shows ST-segment elevation, indicating ongoing damage to the heart.

Common Symptoms of ACS

  • Chest pain is often described as squeezing in the chest, which may radiate to the arms, jaw, neck, shoulder, back, or abdomen.
  • Levine’s sign presents as a clenched fist over the sternum.
  • Epigastric pain may occur, and pain does not change with alterations in position, respiration, or cough.
  • Shortness of breath may be present, especially with exertion or at rest.
  • Nausea and vomiting may occur.
  • Sweating, often described as diaphoresis, can occur.
  • Fatigue may occur, with increased tiredness or becoming fatigued early during activity.
  • Dizziness may occur, due to inadequate cardiac function, dysrhythmia, and/or low ejection fraction.

Immediate Medical Attention for ACS

  • Diagnosis involves clinical evaluation, ECG findings, and blood tests to assess cardiac biomarkers.

Treatment Strategies for ACS

  • Treatment aims to restore blood flow to the affected heart area.
  • Common medications administered include Aspirin, nitroglycerin, and anticoagulants.
  • MONA = Morphine, Oxygen, Nitro, Aspirin.

Medications

  • Nitrates act as vasodilators to open all vasculature.
  • Aspirin reduces platelet adherence to limit clotting.
  • Beta blockers decrease myocardial oxygen demand.
  • Calcium antagonists cause arteriole dilation and decrease systemic vascular resistance.
  • ACE inhibitors decrease BP and resistance and prevent further remodeling of the heart for heart failure patients.

Reperfusion Therapy

  • Percutaneous coronary intervention (PCI) or fibrinolytic therapy (thrombolytic therapy) are performed to restore blood flow.

Oxygen therapy

  • Supplemental oxygen is provided to ensure adequate oxygenation only if O2 sats are low.

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Description

This lesson covers acute coronary syndrome (ACS), including unstable angina and NSTEMI. ACS is a medical emergency often caused by plaque rupture in a coronary artery, leading to blood clot formation. Unstable angina presents with severe chest pain, while NSTEMI involves myocardial damage indicated by elevated cardiac biomarkers.

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