Acid-Base regulation L1-3

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Questions and Answers

Why is maintaining acid base balance critical for cell function?

  • It regulates potassium levels in cells
  • It maintains protein structure and enzyme function (correct)
  • It inhibits metabolic waste excretion
  • It promotes oxygen delivery to cells

What statement accurately describes the relationship between hydrogen ion concentration and pH?

  • A higher H+ concentration corresponds to a higher pH
  • A lower H+ concentration corresponds to a lower pH
  • pH is the negative logarithm of H+ concentration (correct)
  • pH and H+ concentration are not related

Which parameter can be measured using the Henderson-Hasselbach equation?

  • Potassium levels in blood
  • Blood oxygen saturation
  • Blood pH (correct)
  • Blood glucose concentration

What is a buffer?

<p>They are a shield or protective mechanism that stops the pH from rising or falling too quickly.</p> Signup and view all the answers

Buffers are either a weak _____ with its conjugate _______, or a weak ______ with its conjugate _____

<p>Buffers are either a weak acid with its conjugate base or a weak base with its conjugate acid</p> Signup and view all the answers

Bases are normally derived from _____

<p>Bases are normally derived from nutrients</p> Signup and view all the answers

Which of the following is an example of a strong acid?

<p>Hydrochloric acid (C)</p> Signup and view all the answers

Which condition could cause metabolic acidosis in animals?

<p>Diabetes mellitus (C)</p> Signup and view all the answers

Most acids and bases present in the ECF behave as weak acids and weak bases. The most important ones are ____ & ___

<p>Most acids and bases present in the ECF behave as weak acids and weak bases. The most important ones are carbonic acid and bicarbonate</p> Signup and view all the answers

Cells under ischemia show a more (acidic/basic) pH than cells under normal circumstances

<p>Cells under ischemia show a more acidic pH than cells under normal circumstances</p> Signup and view all the answers

What two conditions cause either a depression or elevation in pH?

<p>Acidemia or Alkalemia</p> Signup and view all the answers

What two terms define a disturbance caused by either the addition of an acid/base or removal of acid/base?

<p>Acidosis and alkalosis</p> Signup and view all the answers

What three systems regulate H+ and HCO3 concentration, and pH in the body?

<p>The buffer systems, lungs and kidneys</p> Signup and view all the answers

The bicarbonate system is a(n)

<p>Extracellular buffer system (B)</p> Signup and view all the answers

The bicarbonate system is considered an open buffer system

<p>True (A)</p> Signup and view all the answers

What are the three buffer systems in the body?

<p>Bicarbonate, phosphate and protein</p> Signup and view all the answers

What compensatory mechanism is activated during metabolic acidosis?

<p>Hyperventilation to decrease PCO2 (B)</p> Signup and view all the answers

Which system acts within seconds to regulate pH?

<p>Buffer systems (D)</p> Signup and view all the answers

Which of the following organs plays a key role in excreting hydrogen ions and reabsorbing bicarbonate?

<p>Kidneys (C)</p> Signup and view all the answers

The bicarbonate buffer system works as an open buffer system because

<p>CO2 can be excreted through the lungs (A)</p> Signup and view all the answers

What happens when the concentration of H+ increases in the bicarbonate buffer system?

<p>H+ binds to HCO3- to form H2CO3 (C)</p> Signup and view all the answers

Which buffer system is especially important in the renal tubule fluid?

<p>Phosphate buffer system (B)</p> Signup and view all the answers

Which protein in RBC serves as a key buffer for hydrogen ions?

<p>Hemoglobin (B)</p> Signup and view all the answers

What effect does hypoventilation have on pH?

<p>Decrease pH (B)</p> Signup and view all the answers

Which of the following conditions is likely to cause respiratory acidosis?

<p>Alveolar hypoventilation (C)</p> Signup and view all the answers

What is the role of type A intercalated cells in the nephron during acidosis ?

<p>Secrete hydrogen ions and reabsorb bicarbonate (B)</p> Signup and view all the answers

How does the kidney compensate during alkalosis?

<p>Secrete bicarbonate and reabsorb hydrogen ions (B)</p> Signup and view all the answers

Which of the following is characteristic of respiratory alkalosis?

<p>Decreased PCO2 and increased pH (B)</p> Signup and view all the answers

Which mechanism contributes to renal regulation of pH?

<p>Secretion of ammonia in the distal nephron (B)</p> Signup and view all the answers

Which of the following would cause an increased anion gap metabolic acidosis?

<p>Lactic acidosis (C)</p> Signup and view all the answers

Which term describes a disturbance characterized by an accumulation of acid or loss of base from the extracellular fluid?

<p>Acidosis (B)</p> Signup and view all the answers

Which buffer system is most effective in the ECF?

<p>Bicarbonate buffer system (B)</p> Signup and view all the answers

During respiratory acidosis, what compensatory response occurs in the kidneys ?

<p>Increased reabsorption of bicarbonate (A)</p> Signup and view all the answers

Which acid is considered a volatile acid in the body?

<p>Carbonic acid (B)</p> Signup and view all the answers

Which acid-base disorder is associated with prolonged vomiting?

<p>Metabolic alkalosis (D)</p> Signup and view all the answers

In a patient with metabolic alkalosis, what compensatory mechanism is likely to occur?

<p>Hypoventilation (B)</p> Signup and view all the answers

What happens to potassium levels during acidosis?

<p>Potassium accumulates in ECF (C)</p> Signup and view all the answers

Which parameter is necessary to evaluate an acid base disturbance?

<p>Arterial pH (B)</p> Signup and view all the answers

Which disorder is characterized by a decreased pH and increased PCO2?

<p>Respiratory acidosis (C)</p> Signup and view all the answers

Which condition can result in hyperkalemia?

<p>Acidosis (C)</p> Signup and view all the answers

Which of the following systems can eliminate non-volatile acids from the body?

<p>Kidneys (C)</p> Signup and view all the answers

What is the role of the Na+/H+ exchanger during acid base regulation in the kidney?

<p>Secretes hydrogen ions into the urine (B)</p> Signup and view all the answers

What effect does increased PCO2 have on blood pH?

<p>Decreases pH (B)</p> Signup and view all the answers

Flashcards

Acid-Base Balance

Maintaining a stable hydrogen ion concentration in the body fluids, crucial for protein structure and enzyme function.

pH

The negative logarithm of hydrogen ion concentration ([H+]).

Henderson-Hasselbalch Equation

A mathematical formula used to calculate the blood pH based on the relationship between carbonic acid and bicarbonate.

Buffer

A substance that resists changes in pH by accepting or donating hydrogen ions.

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Weak Acid/Conjugate Base Buffer

A buffer system composed of a weak acid and its conjugate base.

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Weak Base/Conjugate Acid Buffer

A buffer system composed of a weak base and its conjugate acid.

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Metabolic Acidosis Cause

Diabetes mellitus is a condition that can lead to metabolic acidosis.

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Buffer Systems

The body's first line of defense against pH changes, operating within seconds.

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Bicarbonate Buffer System

The primary extracellular buffer system, crucial for maintaining stable pH.

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Open Buffer System

A buffer system where one component can be eliminated from the body, providing flexibility.

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Phosphate Buffer System

Important in the renal tubule fluid for regulating pH.

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Hemoglobin Buffer

A protein in red blood cells that acts as a buffer for hydrogen ions.

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Respiratory Acidosis

A condition caused by decreased removal of CO2 from the body.

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Respiratory Alkalosis

A condition caused by excessive removal of CO2 from the body.

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Metabolic Alkalosis

A condition resulting from excessive loss of hydrogen ions or gain of bicarbonate.

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Type A intercalated cells

Kidney cells that secrete hydrogen ions and reabsorb bicarbonate.

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Ischemia

Reduced blood flow to tissues, leading to acidity.

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Hyperventilation

Increased rate and depth of breathing.

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Hypoventilation

Decreased rate and depth of breathing.

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