Acid-Base regulation L1-3
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Questions and Answers

Why is maintaining acid base balance critical for cell function?

  • It regulates potassium levels in cells
  • It maintains protein structure and enzyme function (correct)
  • It inhibits metabolic waste excretion
  • It promotes oxygen delivery to cells
  • What statement accurately describes the relationship between hydrogen ion concentration and pH?

  • A higher H+ concentration corresponds to a higher pH
  • A lower H+ concentration corresponds to a lower pH
  • pH is the negative logarithm of H+ concentration (correct)
  • pH and H+ concentration are not related
  • Which parameter can be measured using the Henderson-Hasselbach equation?

  • Potassium levels in blood
  • Blood oxygen saturation
  • Blood pH (correct)
  • Blood glucose concentration
  • What is a buffer?

    <p>They are a shield or protective mechanism that stops the pH from rising or falling too quickly.</p> Signup and view all the answers

    Buffers are either a weak _____ with its conjugate _______, or a weak ______ with its conjugate _____

    <p>Buffers are either a weak acid with its conjugate base or a weak base with its conjugate acid</p> Signup and view all the answers

    Bases are normally derived from _____

    <p>Bases are normally derived from nutrients</p> Signup and view all the answers

    Which of the following is an example of a strong acid?

    <p>Hydrochloric acid</p> Signup and view all the answers

    Which condition could cause metabolic acidosis in animals?

    <p>Diabetes mellitus</p> Signup and view all the answers

    Most acids and bases present in the ECF behave as weak acids and weak bases. The most important ones are ____ & ___

    <p>Most acids and bases present in the ECF behave as weak acids and weak bases. The most important ones are carbonic acid and bicarbonate</p> Signup and view all the answers

    Cells under ischemia show a more (acidic/basic) pH than cells under normal circumstances

    <p>Cells under ischemia show a more acidic pH than cells under normal circumstances</p> Signup and view all the answers

    What two conditions cause either a depression or elevation in pH?

    <p>Acidemia or Alkalemia</p> Signup and view all the answers

    What two terms define a disturbance caused by either the addition of an acid/base or removal of acid/base?

    <p>Acidosis and alkalosis</p> Signup and view all the answers

    What three systems regulate H+ and HCO3 concentration, and pH in the body?

    <p>The buffer systems, lungs and kidneys</p> Signup and view all the answers

    The bicarbonate system is a(n)

    <p>Extracellular buffer system</p> Signup and view all the answers

    The bicarbonate system is considered an open buffer system

    <p>True</p> Signup and view all the answers

    What are the three buffer systems in the body?

    <p>Bicarbonate, phosphate and protein</p> Signup and view all the answers

    What compensatory mechanism is activated during metabolic acidosis?

    <p>Hyperventilation to decrease PCO2</p> Signup and view all the answers

    Which system acts within seconds to regulate pH?

    <p>Buffer systems</p> Signup and view all the answers

    Which of the following organs plays a key role in excreting hydrogen ions and reabsorbing bicarbonate?

    <p>Kidneys</p> Signup and view all the answers

    The bicarbonate buffer system works as an open buffer system because

    <p>CO2 can be excreted through the lungs</p> Signup and view all the answers

    What happens when the concentration of H+ increases in the bicarbonate buffer system?

    <p>H+ binds to HCO3- to form H2CO3</p> Signup and view all the answers

    Which buffer system is especially important in the renal tubule fluid?

    <p>Phosphate buffer system</p> Signup and view all the answers

    Which protein in RBC serves as a key buffer for hydrogen ions?

    <p>Hemoglobin</p> Signup and view all the answers

    What effect does hypoventilation have on pH?

    <p>Decrease pH</p> Signup and view all the answers

    Which of the following conditions is likely to cause respiratory acidosis?

    <p>Alveolar hypoventilation</p> Signup and view all the answers

    What is the role of type A intercalated cells in the nephron during acidosis ?

    <p>Secrete hydrogen ions and reabsorb bicarbonate</p> Signup and view all the answers

    How does the kidney compensate during alkalosis?

    <p>Secrete bicarbonate and reabsorb hydrogen ions</p> Signup and view all the answers

    Which of the following is characteristic of respiratory alkalosis?

    <p>Decreased PCO2 and increased pH</p> Signup and view all the answers

    Which mechanism contributes to renal regulation of pH?

    <p>Secretion of ammonia in the distal nephron</p> Signup and view all the answers

    Which of the following would cause an increased anion gap metabolic acidosis?

    <p>Lactic acidosis</p> Signup and view all the answers

    Which term describes a disturbance characterized by an accumulation of acid or loss of base from the extracellular fluid?

    <p>Acidosis</p> Signup and view all the answers

    Which buffer system is most effective in the ECF?

    <p>Bicarbonate buffer system</p> Signup and view all the answers

    During respiratory acidosis, what compensatory response occurs in the kidneys ?

    <p>Increased reabsorption of bicarbonate</p> Signup and view all the answers

    Which acid is considered a volatile acid in the body?

    <p>Carbonic acid</p> Signup and view all the answers

    Which acid-base disorder is associated with prolonged vomiting?

    <p>Metabolic alkalosis</p> Signup and view all the answers

    In a patient with metabolic alkalosis, what compensatory mechanism is likely to occur?

    <p>Hypoventilation</p> Signup and view all the answers

    What happens to potassium levels during acidosis?

    <p>Potassium accumulates in ECF</p> Signup and view all the answers

    Which parameter is necessary to evaluate an acid base disturbance?

    <p>Arterial pH</p> Signup and view all the answers

    Which disorder is characterized by a decreased pH and increased PCO2?

    <p>Respiratory acidosis</p> Signup and view all the answers

    Which condition can result in hyperkalemia?

    <p>Acidosis</p> Signup and view all the answers

    Which of the following systems can eliminate non-volatile acids from the body?

    <p>Kidneys</p> Signup and view all the answers

    What is the role of the Na+/H+ exchanger during acid base regulation in the kidney?

    <p>Secretes hydrogen ions into the urine</p> Signup and view all the answers

    What effect does increased PCO2 have on blood pH?

    <p>Decreases pH</p> Signup and view all the answers

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