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AChE Structure and Function Quiz

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Questions and Answers

What is the general secondary structure of AChE?

12-stranded mixed beta-sheet and 14 alpha helices (correct)

8-stranded beta-sheet and 12 alpha helices

14-stranded mixed beta-sheet and 10 alpha helices

10-stranded beta-sheet and 16 alpha helices

Where is the active site of AChE located?

On the surface of the protein

At the entrance of the gorge

Within the alpha helices

At the bottom of a deep, narrow gorge (correct)

What lines the entrance of the gorge in which the active site is located?

16 hydrophobic residues

8 basic amino acid residues

14 aromatic residues (correct)

12 acidic amino acid residues

What causes the ACh substrate to be attracted to the gorge and 'hop' or 'slide' down to the active site?

Interaction of pi-orbitals of aromatic rings with cationic side chains Signup and view all the answers

What contributes to the faster rate of reaction at low substrate concentration in AChE?

A large dipole moment oriented along the axis of the gorge Signup and view all the answers

What happens when the enzyme Acetylcholinesterase (AChE) misfolds?

It loses its ability to regulate the termination of neuron transmission Signup and view all the answers

What effect does a high concentration of acetylcholine have on post-synaptic receptors?

It makes them less responsive to the neurotransmitter Signup and view all the answers

What can result from an extreme cholinergic crisis?

Reduced heart rate, difficulty breathing, and paralysis Signup and view all the answers

What impact does an excessive amount of AChE have on acetylcholine in the synapse?

Reduction of acetylcholine in the synapse Signup and view all the answers

What chronic diseases can result from an imbalance of acetylcholine in the synapse?

Alzheimer's and Dementia Signup and view all the answers