Podcast
Questions and Answers
What is the general secondary structure of AChE?
What is the general secondary structure of AChE?
- 12-stranded mixed beta-sheet and 14 alpha helices (correct)
- 8-stranded beta-sheet and 12 alpha helices
- 14-stranded mixed beta-sheet and 10 alpha helices
- 10-stranded beta-sheet and 16 alpha helices
Where is the active site of AChE located?
Where is the active site of AChE located?
- On the surface of the protein
- At the entrance of the gorge
- Within the alpha helices
- At the bottom of a deep, narrow gorge (correct)
What lines the entrance of the gorge in which the active site is located?
What lines the entrance of the gorge in which the active site is located?
- 16 hydrophobic residues
- 8 basic amino acid residues
- 14 aromatic residues (correct)
- 12 acidic amino acid residues
What causes the ACh substrate to be attracted to the gorge and 'hop' or 'slide' down to the active site?
What causes the ACh substrate to be attracted to the gorge and 'hop' or 'slide' down to the active site?
What contributes to the faster rate of reaction at low substrate concentration in AChE?
What contributes to the faster rate of reaction at low substrate concentration in AChE?
What happens when the enzyme Acetylcholinesterase (AChE) misfolds?
What happens when the enzyme Acetylcholinesterase (AChE) misfolds?
What effect does a high concentration of acetylcholine have on post-synaptic receptors?
What effect does a high concentration of acetylcholine have on post-synaptic receptors?
What can result from an extreme cholinergic crisis?
What can result from an extreme cholinergic crisis?
What impact does an excessive amount of AChE have on acetylcholine in the synapse?
What impact does an excessive amount of AChE have on acetylcholine in the synapse?
What chronic diseases can result from an imbalance of acetylcholine in the synapse?
What chronic diseases can result from an imbalance of acetylcholine in the synapse?
Flashcards are hidden until you start studying
