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AChE Structure and Function Quiz
10 Questions
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AChE Structure and Function Quiz

Created by
@CongenialChrysoberyl

Questions and Answers

What is the general secondary structure of AChE?

  • 12-stranded mixed beta-sheet and 14 alpha helices (correct)
  • 8-stranded beta-sheet and 12 alpha helices
  • 14-stranded mixed beta-sheet and 10 alpha helices
  • 10-stranded beta-sheet and 16 alpha helices

    • Where is the active site of AChE located?

  • On the surface of the protein
  • At the entrance of the gorge
  • Within the alpha helices
  • At the bottom of a deep, narrow gorge (correct)

    • What lines the entrance of the gorge in which the active site is located?

  • 16 hydrophobic residues
  • 8 basic amino acid residues
  • 14 aromatic residues (correct)
  • 12 acidic amino acid residues

    • What causes the ACh substrate to be attracted to the gorge and 'hop' or 'slide' down to the active site?

    <p>Interaction of pi-orbitals of aromatic rings with cationic side chains</p> Signup and view all the answers

    What contributes to the faster rate of reaction at low substrate concentration in AChE?

    <p>A large dipole moment oriented along the axis of the gorge</p> Signup and view all the answers

    What happens when the enzyme Acetylcholinesterase (AChE) misfolds?

    <p>It loses its ability to regulate the termination of neuron transmission</p> Signup and view all the answers

    What effect does a high concentration of acetylcholine have on post-synaptic receptors?

    <p>It makes them less responsive to the neurotransmitter</p> Signup and view all the answers

    What can result from an extreme cholinergic crisis?

    <p>Reduced heart rate, difficulty breathing, and paralysis</p> Signup and view all the answers

    What impact does an excessive amount of AChE have on acetylcholine in the synapse?

    <p>Reduction of acetylcholine in the synapse</p> Signup and view all the answers

    What chronic diseases can result from an imbalance of acetylcholine in the synapse?

    <p>Alzheimer's and Dementia</p> Signup and view all the answers

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