Pyridostigmine Bromide Flashcards

Questions and Answers

What is the class of pyridostigmine bromide?

Beta-blocker

Antidepressant

Calcium channel blocker

AchE inhibitor (correct)

What is the mechanism of action (MOA) of pyridostigmine bromide?

Inhibits the breakdown of acetylcholine in the brainstem, increases acetylcholine.

What condition is pyridostigmine bromide indicated for?

Myasthenia gravis

What are the contraindications for pyridostigmine bromide?

GI obstruction Signup and view all the answers

What precautions should be considered when administering pyridostigmine bromide?

Asthma, peptic ulcer, renal dysfunction, cardiac dysrhythmia, seizure. Signup and view all the answers

How should pyridostigmine bromide be administered?

By mouth (PO) and on an empty stomach. Signup and view all the answers

What are some of the side effects (s/s) of pyridostigmine bromide?

Seizure, nausea/vomiting, diarrhea, respiratory depression, bronchospasm, cardiac dysrhythmias, bradycardia, orthostatic hypotension, miosis, blurry vision, dyskinesia, diaphoresis, salivation. Signup and view all the answers

What nursing implications should be considered when giving pyridostigmine bromide?

Give on time, give on an empty stomach, assess dysphagia, assess vital signs, safety precautions, seizure precautions, avoid other anticholinergic drugs. Signup and view all the answers

What is the antidote for cholinergic crisis?

Atropine sulfate. Signup and view all the answers

Study Notes

Pyridostigmine Bromide Overview

Class: Acetylcholinesterase (AchE) inhibitor
Mechanism of Action (MOA): Inhibits breakdown of acetylcholine (Ach), increasing Ach levels in the brainstem
Indication (IND): Primarily used for treating Myasthenia gravis

Contraindications and Cautions

Contraindications: Gastrointestinal (GI) or genitourinary (GU) obstruction
Cautions: Use with care in patients with asthma, peptic ulcers, renal dysfunction, cardiac dysrhythmia, and seizure disorders

Pharmacokinetics and Administration

Pharmacology: Food intake decreases absorption; administer on an empty stomach
Administration route: Oral (PO)

Side Effects and Symptoms

Common side effects:
- Seizures
- Nausea and vomiting (N/V)
- Diarrhea
- Respiratory depression
- Bronchospasm
- Cardiac dysrhythmias
- Bradycardia
- Orthostatic hypotension
- Miosis (constricted pupils)
- Blurry vision
- Dyskinesia
- Diaphoresis (excessive sweating)
- Increased salivation

Nursing Implications

Ensure medication is administered punctually
Administer on an empty stomach to maximize absorption
Assess for swallowing difficulties (dysphagia)
Monitor vital signs (VS)
Implement safety precautions to prevent falls
Seizure precautions are essential
Avoid co-administration with other anticholinergic drugs

Antidote for Cholinergic Crisis

Antidote: Atropine sulfate used to counteract overdoses or severe side effects of cholinergic agents

Description

Test your knowledge on pyridostigmine bromide with these flashcards. Learn about its class, mechanism of action, indications, contraindications, and precautions. Perfect for students and healthcare professionals interested in pharmacology.