Podcast
Questions and Answers
What is the primary purpose of acetylcholine in the nervous system?
What is the primary purpose of acetylcholine in the nervous system?
- Short distance signaling
- Neurotransmission regulation
- Synaptic plasticity modulation
- Long distance signaling (correct)
What type of receptors are nicotinic AChRs classified as?
What type of receptors are nicotinic AChRs classified as?
- G-protein coupled receptors
- Tyrosine kinase receptors
- Ligand-gated ion channels (correct)
- Cytokine receptors
Which of the following brain regions is NOT a major cholinergic nucleus?
Which of the following brain regions is NOT a major cholinergic nucleus?
- Cerebellum (correct)
- Thalamus
- Hippocampus
- Caudate nucleus
What is the role of vesicular ACh transporter (VAChT) in ACh synthesis?
What is the role of vesicular ACh transporter (VAChT) in ACh synthesis?
What is the effect of nicotinic AChRs on CNS neurons?
What is the effect of nicotinic AChRs on CNS neurons?
What is the primary function of acetylcholinesterase (AChE) in the nervous system?
What is the primary function of acetylcholinesterase (AChE) in the nervous system?
Which of the following diseases is NOT associated with the cholinergic system?
Which of the following diseases is NOT associated with the cholinergic system?
What is the enzyme responsible for synthesizing ACh from acetyl-CoA and choline?
What is the enzyme responsible for synthesizing ACh from acetyl-CoA and choline?
What is the mechanism of action of partial agonists like varenicline in nicotine dependency?
What is the mechanism of action of partial agonists like varenicline in nicotine dependency?
What is the effect of acetylcholinesterase inhibitors like donepezil on ACh levels?
What is the effect of acetylcholinesterase inhibitors like donepezil on ACh levels?
Which of the following muscarinic drugs is used for motion sickness?
Which of the following muscarinic drugs is used for motion sickness?
What is the therapeutic target for Alzheimer's disease?
What is the therapeutic target for Alzheimer's disease?
Which CNS disease is associated with mAChRs?
Which CNS disease is associated with mAChRs?
What is the effect of the S247F mutation in alpha 4 subunit of nAChRs in ADNFLE?
What is the effect of the S247F mutation in alpha 4 subunit of nAChRs in ADNFLE?
What is the therapeutic target for drug dependency?
What is the therapeutic target for drug dependency?
What type of receptor channelopathy is autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)?
What type of receptor channelopathy is autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE)?
What is the effect of the S247F mutation in alpha 4 subunit of nAChRs on calcium release?
What is the effect of the S247F mutation in alpha 4 subunit of nAChRs on calcium release?
What is the effect of muscarinic AChRs on potassium channels during slow depolarization?
What is the effect of muscarinic AChRs on potassium channels during slow depolarization?
What is the primary function of calcium-activated potassium channels in the context of slow hyperpolarization?
What is the primary function of calcium-activated potassium channels in the context of slow hyperpolarization?
What is the typical subunit composition of nicotinic ACh receptors in the CNS?
What is the typical subunit composition of nicotinic ACh receptors in the CNS?
Which of the following muscarinic AChR subtypes is typically found postsynaptically and is Gq-coupled?
Which of the following muscarinic AChR subtypes is typically found postsynaptically and is Gq-coupled?
What is the primary effect of nicotine on dopamine levels in the mesocorticolimbic pathways?
What is the primary effect of nicotine on dopamine levels in the mesocorticolimbic pathways?
What is the novel analgesic that acts on nicotinic AChRs?
What is the novel analgesic that acts on nicotinic AChRs?
What is the correlation between smoking and the incidence of Alzheimer's disease?
What is the correlation between smoking and the incidence of Alzheimer's disease?
What is the primary difference between nicotinic and muscarinic AChRs?
What is the primary difference between nicotinic and muscarinic AChRs?