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Questions and Answers
What does the term 'c - x' represent in the context of the equation provided?
What does the term 'c - x' represent in the context of the equation provided?
- The volume of the solution
- The initial concentration of the solute (correct)
- The concentration of the solute after dissociation
- The amount of solute removed from the solution
How many moles of acetate ions were found in the 0.1 M solution of acetic acid?
How many moles of acetate ions were found in the 0.1 M solution of acetic acid?
- 1.32 × 10−3 moles (correct)
- 3.2 × 10−2 moles
- 1.0 moles
- 0.1 moles
At what temperature was the conductivity analysis conducted for the acetic acid solution?
At what temperature was the conductivity analysis conducted for the acetic acid solution?
- 50°C
- 100°C
- 25°C (correct)
- 0°C
What is the approximate error when replacing 'c - x' with 'c' in the equations described?
What is the approximate error when replacing 'c - x' with 'c' in the equations described?
What ions were dissociated from the acetic acid in the solution?
What ions were dissociated from the acetic acid in the solution?
Which of the following compounds is NOT considered a protogenic solvent?
Which of the following compounds is NOT considered a protogenic solvent?
What is the primary characteristic of a protogenic solvent?
What is the primary characteristic of a protogenic solvent?
Which of the following is an example of a protogenic solvent?
Which of the following is an example of a protogenic solvent?
How is liquid HF classified in the context of protogenic solvents?
How is liquid HF classified in the context of protogenic solvents?
Which of the following substances would be classified under protogenic solvents?
Which of the following substances would be classified under protogenic solvents?
What is the range of pH values indicating acidity on the numeric scale?
What is the range of pH values indicating acidity on the numeric scale?
At what concentration does the H ion concentration in a strong acidic solution approximate 1?
At what concentration does the H ion concentration in a strong acidic solution approximate 1?
Which statement accurately describes the Brønsted–Lowry nomenclature?
Which statement accurately describes the Brønsted–Lowry nomenclature?
What is the H ion concentration in a 1 M solution of a strong base?
What is the H ion concentration in a 1 M solution of a strong base?
What does a pH value of 14 indicate about a solution?
What does a pH value of 14 indicate about a solution?
What term is used for acids that donate a single proton?
What term is used for acids that donate a single proton?
What do we call bases that accept a single proton?
What do we call bases that accept a single proton?
What characterizes monoprotic electrolytes?
What characterizes monoprotic electrolytes?
Which of the following describes a monoprotic acid?
Which of the following describes a monoprotic acid?
Which of these is an example of a monoprotic electrolyte?
Which of these is an example of a monoprotic electrolyte?
What does the acidity constant Ka represent?
What does the acidity constant Ka represent?
What is the relationship between the dissociation constants of a weak acid and its conjugate base?
What is the relationship between the dissociation constants of a weak acid and its conjugate base?
Which statement about acetic acid and its dissociation is true?
Which statement about acetic acid and its dissociation is true?
What factor does not affect the value of the acidity constant Ka?
What factor does not affect the value of the acidity constant Ka?
Under which condition would we compare Ka and Kb for an acid-base pair?
Under which condition would we compare Ka and Kb for an acid-base pair?
What is typically assumed about the concentrations of the weak acids in a system containing two weak acids?
What is typically assumed about the concentrations of the weak acids in a system containing two weak acids?
What ions are produced when a salt of a weak acid and a weak base, such as ammonium acetate, dissociates in aqueous solution?
What ions are produced when a salt of a weak acid and a weak base, such as ammonium acetate, dissociates in aqueous solution?
In the context of ionic equilibria, what is the primary effect of having the salts of weak acids and weak bases in solution?
In the context of ionic equilibria, what is the primary effect of having the salts of weak acids and weak bases in solution?
Which of the following statements is true regarding the salt dissociation in weak acid and weak base systems?
Which of the following statements is true regarding the salt dissociation in weak acid and weak base systems?
When considering two weak acids, which variables are assumed to be effectively zero in these systems?
When considering two weak acids, which variables are assumed to be effectively zero in these systems?
Flashcards
Protophilic solvent
Protophilic solvent
A substance capable of accepting a proton (H+ ion). Examples include acetone, ether, and liquid ammonia.
Protogenic solvent
Protogenic solvent
A substance capable of donating a proton (H+ ion). Examples include formic acid, acetic acid, sulfuric acid, liquid HCl, and liquid HF.
Proton acceptor
Proton acceptor
A substance which accepts a proton (H+ ion) to form a new species.
Proton donor
Proton donor
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Proton transfer
Proton transfer
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Sörensen's pH
Sörensen's pH
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Acidity
Acidity
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Alkalinity
Alkalinity
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pH Scale
pH Scale
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H+ Concentration
H+ Concentration
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What is the acidity constant (Ka)?
What is the acidity constant (Ka)?
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What is a proton acceptor?
What is a proton acceptor?
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What is a proton donor?
What is a proton donor?
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What is proton transfer?
What is proton transfer?
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What is an amphiprotic solvent?
What is an amphiprotic solvent?
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Monoprotic electrolytes
Monoprotic electrolytes
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What does a monoprotic acid donate?
What does a monoprotic acid donate?
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What does a monoprotic base accept?
What does a monoprotic base accept?
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What happens to monoprotic acids and bases after proton transfer?
What happens to monoprotic acids and bases after proton transfer?
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What happens during a reaction between a monoprotic acid and base?
What happens during a reaction between a monoprotic acid and base?
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Neglecting 'x' in equilibrium constant expression (Kc)
Neglecting 'x' in equilibrium constant expression (Kc)
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Equilibrium constant (Kc)
Equilibrium constant (Kc)
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Molarity (M)
Molarity (M)
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Ionization constant (Ka)
Ionization constant (Ka)
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Acetate ions and hydronium ions
Acetate ions and hydronium ions
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Simplifying pH Calculation in Systems with Two Weak Acids
Simplifying pH Calculation in Systems with Two Weak Acids
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Salt of a Weak Acid and Weak Base Dissociation
Salt of a Weak Acid and Weak Base Dissociation
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pH Determination in Salt of Weak Acid and Base Solutions
pH Determination in Salt of Weak Acid and Base Solutions
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Hydrolysis Equilibrium Constant
Hydrolysis Equilibrium Constant
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pH Calculation for Salt of Weak Acid and Base
pH Calculation for Salt of Weak Acid and Base
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Study Notes
Physical Pharmacy I - 2nd Stage
- Topic: Ionic Equilibria (2024-2025)
Objectives
- Define acids and bases
- Understand Sörensen's pH scale
- Understand terminology like Ampholytes, Aprotic, etc.
- Explain ionization of Polyprotic electrolytes
- Calculate pKa and pH of aqueous solutions with different compositions
Theories
-
Arrhenius Theory:
- Acid: A substance releasing hydrogen ions.
- Base: A substance releasing hydroxide ions upon dissociation in aqueous media.
-
Brønsted-Lowry Theory:
- Acid: A substance donating a proton.
- Base: A substance accepting a proton.
- Conjugate acid-base pairs explained.
Solvent Classification
- Protophilic/Basic: Accepts protons from the solute.
- Protogenic: Donates protons to the solute.
- Amphiprotic: Can both accept and donate protons, e.g., water.
- Aprotic: Neither accept nor donate protons, e.g., hydrocarbons.
Proteolytic Reactions (Protolysis)
- Acid-base reactions involving proton transfer.
- Also known as protonation-deprotonation reactions.
Sörensen's pH
- pH scale quantifies acidity and alkalinity (0-14).
- pH 7 is neutral, equal hydrogen and hydroxyl ion concentrations.
- pH values at different temperatures are stated.
Ionic Equilibria
- Equilibrium: A balance between opposing forces/reactions.
- Dynamic equality between opposing reaction velocities.
- Equilibrium condition where standard free energy difference is zero.
- Explanation of the equilibrium constants involved in the process
Lewis Electronic Theory
- Acid: Accepts an electron pair.
- Base: Donates an electron pair.
Ionization of Polyprotic Electrolytes
- Acids/bases donating/accepting multiple protons.
- Diprotic (e.g., carbonic acid) and triprotic (e.g., phosphoric acid) acids ionizing in multiple stages.
Ampholytes
- Species acting as both acid and base.
- Amino acids and proteins are amphoteric/ampholytes.
- Explanation of zwitterions.
Isoelectric Point (IEP)
- pH where zwitterion concentration is maximum for protein and amino acids
- Represents the point at which the molecule has no net charge.
- Solubility and other properties depend on the IEP.
- pH of milk and casein has been stated.
Solutions Containing Strong Acids
- H+ ion concentration fully ionizes.
- H+ concentration is equal to the concentration of the strong acid.
Solutions Containing Weak Acids
- Incomplete ionization
- Calculate the pH using equilibrium expressions: [H₃O+] = √(KₐCₐ)
Solutions Containing a Single Conjugate Acid-Base Pair
- Calculate pH for solutions with both a weak acid and its salt (conjugate base) or vice versa.
- Using the respective acid dissociation constant (Kₐ) or conjugate base dissociation constants (Kᵦ), or K₁ and K₂ constants involved in this type of equilibria equations
Solutions Containing Two Weak Acids
- The dominant equilibrium occurs via the equation [H₃O+] = √(K₁C₁ + K₂C₂) .
- Examples of calculating pH have been given when considering the concentration of two weak acids by using their K₁ and K₂ constants
Solutions Containing a Salt of a Weak Acid and a Weak Base
- The overall ionization process involves the ionization of the weak base and/or weak acid.
- The overall ionization process is often complicated due to the presence of multiple species.
- In most instances, [H₃O+] = √K₁K₂
Solutions Containing a Weak Acid and A Weak Base
- Calculation of pH using the equilibrium expression with K₁ and K₂
- Examples have been given for both weak acid and weak base types of solutions
Ionic Strength
- A measure of the total ion concentration in a solution.
- The calculation of ionic strength has been mentioned for various types of electrolytes
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