Podcast
Questions and Answers
What common drug ending is associated with ACE inhibitors?
What common drug ending is associated with ACE inhibitors?
- -sartan
- -pril (correct)
- -olol
- -dipine
Which of the following statements about the mechanism of action of ACE inhibitors is true?
Which of the following statements about the mechanism of action of ACE inhibitors is true?
- They inhibit ACE, reducing angiotensin II and aldosterone levels. (correct)
- They have no effect on blood pressure regulation.
- They cause vasoconstriction by inhibiting bradykinins.
- They increase the levels of angiotensin II and aldosterone.
Which ACE inhibitor is recommended for patients with decreased kidney function?
Which ACE inhibitor is recommended for patients with decreased kidney function?
- Lisinopril
- Enalapril
- Fosinopril (correct)
- Captopril
What is a common adverse reaction associated with ACE inhibitors?
What is a common adverse reaction associated with ACE inhibitors?
Which of the following ACE inhibitors is classified as a prodrug?
Which of the following ACE inhibitors is classified as a prodrug?
Flashcards
ACE Inhibitors
ACE Inhibitors
Medications that inhibit angiotensin converting enzyme to treat cardiovascular conditions and hypertension.
Mechanism of Action
Mechanism of Action
Inhibition of angiotensin converting enzyme reduces angiotensin II, leading to vasodilation and lower blood pressure.
Bradykinins
Bradykinins
Peptides that cause dilation of arteries, accumulated due to ACE inhibition.
Contraindications
Contraindications
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Common Adverse Reaction
Common Adverse Reaction
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Study Notes
ACE Inhibitors
- Therapeutic Class: Angiotensin Converting Enzyme Inhibitors
- Common Name: ACE Inhibitors
- Common Ending: -pril
- Mechanism of Action:
- Inhibits the activity of ACE (angiotensin converting enzyme) which prevents Angiotensin I from being converted to Angiotensin II
- Reduces levels of angiotensin II and aldosterone
- Angiotensin II is a potent vasoconstrictor, stimulating aldosterone release and increasing blood pressure
- Aldosterone contributes to increased blood pressure
- Bradykinin accumulation reduces peripheral resistance, as bradykinins are peptides that dilate arteries
- Commonly Used to Treat: Cardiovascular conditions, Hypertension
- Notes:
- First-line treatment for patients with Chronic Kidney Disease, Diabetes, or Coronary Artery Disease (CAD)
- Fosinopril is a good choice for patients with decreased kidney function
- Enalapril, perindopril, quinapril, ramipril, trandolapril are prodrugs
- Prodrugs are not ideal for patients with decreased liver function
- Captopril and lisinopril are active compounds
- Fosinopril is 50% eliminated by the kidney and 50% by liver; all other ACE inhibitors are 90% eliminated by the kidney
- Contraindicated in pregnancy due to potential interference with fetal kidney development or causing fetal death
- Common Adverse Reaction: Dry cough (due to bradykinin accumulation), hypotension, lightheadedness
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