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Questions and Answers
What common drug ending is associated with ACE inhibitors?
What common drug ending is associated with ACE inhibitors?
Which of the following statements about the mechanism of action of ACE inhibitors is true?
Which of the following statements about the mechanism of action of ACE inhibitors is true?
Which ACE inhibitor is recommended for patients with decreased kidney function?
Which ACE inhibitor is recommended for patients with decreased kidney function?
What is a common adverse reaction associated with ACE inhibitors?
What is a common adverse reaction associated with ACE inhibitors?
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Which of the following ACE inhibitors is classified as a prodrug?
Which of the following ACE inhibitors is classified as a prodrug?
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Study Notes
ACE Inhibitors
- Therapeutic Class: Angiotensin Converting Enzyme Inhibitors
- Common Name: ACE Inhibitors
- Common Ending: -pril
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Mechanism of Action:
- Inhibits the activity of ACE (angiotensin converting enzyme) which prevents Angiotensin I from being converted to Angiotensin II
- Reduces levels of angiotensin II and aldosterone
- Angiotensin II is a potent vasoconstrictor, stimulating aldosterone release and increasing blood pressure
- Aldosterone contributes to increased blood pressure
- Bradykinin accumulation reduces peripheral resistance, as bradykinins are peptides that dilate arteries
- Commonly Used to Treat: Cardiovascular conditions, Hypertension
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Notes:
- First-line treatment for patients with Chronic Kidney Disease, Diabetes, or Coronary Artery Disease (CAD)
- Fosinopril is a good choice for patients with decreased kidney function
- Enalapril, perindopril, quinapril, ramipril, trandolapril are prodrugs
- Prodrugs are not ideal for patients with decreased liver function
- Captopril and lisinopril are active compounds
- Fosinopril is 50% eliminated by the kidney and 50% by liver; all other ACE inhibitors are 90% eliminated by the kidney
- Contraindicated in pregnancy due to potential interference with fetal kidney development or causing fetal death
- Common Adverse Reaction: Dry cough (due to bradykinin accumulation), hypotension, lightheadedness
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Description
This quiz covers ACE inhibitors, a class of medications used primarily in treating hypertension and cardiovascular conditions. It explores their mechanism of action, common uses, and specific considerations for certain patient populations. Test your knowledge on the key aspects of this important therapeutic class.
